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This pan-cancer study examines MVP expression and its links to clinical outcomes and immune infiltration across diverse tumors. Using extensive transcriptomic and clinical data from public databases, the study finds that higher MVP expression associates with cancer progression and poorer overall survival. The work also validates MVP expression and related function in A549 and AGS cell lines.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-prognostic-value-and-immunological-role-of-mvp-in-pan-cancer-study/330804/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-prognostic-value-and-immunological-role-of-mvp-in-pan-cancer-study/330804.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main research focus of this pan-cancer study?","Question",{"text":112,"@type":113},"The study investigates MVP expression and its correlation with clinical outcomes and immune infiltration across diverse cancer types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does MVP expression relate to patient prognosis in the findings?",{"text":117,"@type":113},"Higher MVP expression is associated with cancer progression and predicts poorer overall survival in multiple cancer types.",{"name":119,"@type":110,"acceptedAnswer":120},"What experimental validation was performed for MVP?",{"text":121,"@type":113},"Expression and function were validated in cancer cell lines A549 and AGS, including functional effects after depleting MVP.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330804,1791565117,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 10  \nResearch Paper  \nThe prognostic value and immunological role of MVP in pan-cancer study  \nChunlin Li 1,*, Min Gao 1,2,*, Nashunbayaer Zha 1, Gang Guo3  \n1 Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China  \n2 Inner Mongolia Medical University, Hohhot 010010, China  \n3 Department of Thyroid and Breast Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China  \n* Equal contribution and share the first authorship  \nCorrespondence to: Gang Guo; email: [20120220@immu.edu.cn](20120220@immu.edu.cn)  \n[Keywords:](Keywords: MVP)[ MVP](Keywords: MVP), pan-cancer, prognosis, methylation, immune  \nReceived: June 19, 2023 Accepted: April 8, 2024 Published: May 6, 2024  \nCopyright: © 2024 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nMajor Vault Protein (MVP) has emerged as a potential prognostic and immunological biomarker in various cancer types. This pan-cancer study aimed to investigate expression of MVP and its correlation with clinical outcomes and immune infiltration across diverse cancer types. We conducted an analysis of extensive transcriptomic and clinical data from publicly available databases. Our findings unveiled a significant association between MVP expression and cancer progression, with higher expression levels predicting poorer overall survival in multiple cancer types. Importantly, MVP expression demonstrated a close relationship with immune infiltration in the tumor microenvironment, showing that higher expression levels were associated with increased immune cell infiltration. We further validated expression of MVP and function in cancer cell lines A549 and AGS. These compelling results suggest that MVP holds promise as a valuable biomarker for prognostic assessment and the development of immunotherapeutic strategies across various cancer types. Consequently, targeting MVP may offer a compelling therapeutic approach in the treatment of human cancers.  \nINTRODUCTION  \nCancer remains a formidable global health challenge despite significant advancements in early detection and treatment, which have contributed to a decline in cancer-related mortality rates [1] . However, the incidence and impact of cancer continue to rise, primarily due to population aging, resulting in persistently low five-year survival rates [2] . Therefore, it is imperative to explore innovative approaches for cancer diagnosis and treatment. The utilization of cancer biomarkers has shown promise, motivating researchers to investigate novel targets for cancer therapy and prognostic markers. Consequently, there  \nis an urgent demand for innovative strategies to enhance cancer diagnosis and therapy, ultimately leading to improved patient outcomes.  \nMajor Vault Protein (MVP) is the predominant constituent of the vault complex, which is the largest known ribonucleoprotein particle. The vault complex is hypothesized to serve as a versatile carrier molecule facilitating nucleocytoplasmic transport. With its distinctive barrel-shaped structure, MVP exhibits significant conservation across diverse species [3–6] . Notably, the involvement of MVP in chemotherapy resistance and its correlation with prognosis have been observed in several cancer types, such as triple-  \n8497  \nnegative breast cancer [7], liver cancer [8], lung cancer [9], and colon cancer [10] . Recent investigations have revealed that the interaction of MVP with interferon regulatory factor 2, as well as its inhibition of p53 activity, may contribute to hepatocellular carcinoma development. Furthermore, elevated MVP expression has been associated with hepatocellular carcinoma progression and poorer overall surviva","cbCaiqZLt1G4qjwH","https://ap.wps.com/l/cbCaiqZLt1G4qjwH","pdf",3020873,14,"English","# Abstract\n# Introduction\n## Background on cancer burden and biomarkers\n## MVP as a vault complex component and its cancer relevance\n# Materials and Methods\n## Data collection and processing","[{\"question\":\"What is the main research focus of this pan-cancer study?\",\"answer\":\"The study investigates MVP expression and its correlation with clinical outcomes and immune infiltration across diverse cancer types.\"},{\"question\":\"How does MVP expression relate to patient prognosis in the findings?\",\"answer\":\"Higher MVP expression is associated with cancer progression and predicts poorer overall survival in multiple cancer types.\"},{\"question\":\"What experimental validation was performed for MVP?\",\"answer\":\"Expression and function were validated in cancer cell lines A549 and AGS, including functional effects after depleting MVP.\"}]","The prognostic value and immunological role of MVP in pan-cancer study | PDF",1789990214,35]