[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373519-105":59,"doc-detail-373519-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-price-of-exposure-xeroderma-pigmentosum-and-skin-cancer","The Price of Exposure - Xeroderma Pigmentosum and Skin Cancer","","Xeroderma pigmentosum (XP) is a rare autosomal recessive DNA repair disorder marked by extreme photosensitivity, pigmentary changes, premature aging, and a high lifetime risk of UV-induced skin and mucous membrane cancers. A case report describes a 55-year-old woman with XP who developed squamous cell carcinoma. The lesion on the left cheek presented as a black nodulo-plaque and was confirmed histopathologically. The report emphasizes research, prevention, genetic counseling, and increased awareness to improve quality of life and reduce malignancy incidence.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-price-of-exposure-xeroderma-pigmentosum-and-skin-cancer/373519/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-price-of-exposure-xeroderma-pigmentosum-and-skin-cancer/373519.png","ImageObject",300,407,{"name":92,"@type":93},"Chumphorn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What causes xeroderma pigmentosum (XP) and what are its main consequences?","Question",{"text":113,"@type":114},"XP is caused by a defect in the nucleotide excision repair pathway of DNA, leading to extreme photosensitivity, pigmentary changes, premature skin aging, and a greatly increased risk of UV-induced cancers.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What was unusual about the reported patient’s squamous cell carcinoma case?",{"text":118,"@type":114},"The patient developed squamous cell carcinoma at age 55, which is described as unusual due to her extended survival compared with typical expectations.",{"name":120,"@type":111,"acceptedAnswer":121},"How did the clinicians assess ocular photosensitivity in this case?",{"text":122,"@type":114},"Ocular photosensitivity was quantified using a standardized UV provocation test, with grading based on erythema after simulated sunlight exposure.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},373519,1790318364,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336475401981,"https://ap-avatar.wpscdn.com/avatar/22000c94efd8d5204d?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786935347598174694","Review began 04/18/2025  \nReview ended 06/09/2025  \nPublished 06/10/2025  \n© Copyright 2025  \nAneja et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.85703  \nOpen Access Case Report  \nThe Price of Exposure: Xeroderma Pigmentosumand Skin Cancer  \nSavi Aneja 1, Mala Bhalla 2, Tanya Jain 2  \n1. Dermatology, Venerology and Leprosy, Government Medical College & Hospital, Chandigarh, Chandigarh, IND 2. Dermatology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND  \nCorresponding author: Savi Aneja, [anejasavi@gmail.com](anejasavi@gmail.com)  \nAbstract  \nXeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis characterized by a defect in the nucleotide excision repair pathway of DNA. This condition leads to extreme photosensitivity, pigmentary changes, premature aging, and increased risk of UV-induced skin and mucous membrane neoplasms. Wereport a case of squamous cell carcinoma in a 55-year-old female with XP. A 55-year-old female presented with a single asymptomatic skin lesion on the left cheek that had developed over the past two  \nyears. Examination revealed a well-defined, round to oval black raised nodulo-plaque, with a central adherent crust and raised superior margin. Histopathological examination revealed an invasive tumor arising from hyperplastic and dysplastic squamous epithelium with cytokeratin positivity. XP presents significant clinical challenges due to its severe photosensitivity and the associated risk of developing multiple skin cancers at a young age, which highlights the necessity for ongoing research into effective treatments and preventive strategies. Genetic counseling can play a vital role for families, enabling them to understand the implications for future generations. Increased awareness can help improve the quality of life and reduce the incidence of associated malignancies.  \nCategories: Dermatology  \nKeywords: autosomal recessive disease, genetic syndromes, squamous cell carcinoma (scc), sun exposure, xeroderma pigmentosum  \nIntroduction  \nXeroderma pigmentosum (XP) is a rare, inherited skin disorder caused by a defect in the DNA repair system, specifically the nucleotide excision repair pathway, which normally repairs damage from ultraviolet (UV) light [1] . This impairment leads to extreme sensitivity to sunlight, changes in skin pigmentation, early-onset skin aging, eye damage, and a dramatically increased risk of UV-induced skin and mucous membrane cancers. In some cases, patients may also develop progressive neurological deterioration. Globally, XP occurs in approximately one in one million births, with higher prevalence in regions with consanguineous marriages, such as parts of North Africa, the Middle East, and Japan.  \nIndividuals with XP face a 10,000-fold higher risk of non-melanoma skin cancers (NMSC) and a 2,000-fold increase in melanoma risk [2] . Among NMSCs, squamous cell carcinoma (SCC) is especially concerning, commonly developing in sun-exposed areas. A large case series and literature review by Baykal et al. found SCC in 25% of XP patients, underscoring its clinical significance [3] . Life expectancy varies significantly depending on neurological involvement: patients with neurodegeneration have a median lifespan of about 29 years, while those without may live up to 37 years [4] .  \nDespite these risks, some individuals with XP survive well beyond typical expectations. We report a case of SCC in a 55-year-old woman with XP, an unusual presentation both because of her extended survival and asa reminder that the risk of UV-related cancers persists lifelong, even in rare long-term survivors.  \nCase Presentation  \nA 55-year-old female from Una, Himachal Pradesh, presented with a single asymptomatic skin lesion on her left cheek","cbCaijxSmoM7ER1U","https://ap.wps.com/l/cbCaijxSmoM7ER1U","pdf",3366149,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What causes xeroderma pigmentosum (XP) and what are its main consequences?\",\"answer\":\"XP is caused by a defect in the nucleotide excision repair pathway of DNA, leading to extreme photosensitivity, pigmentary changes, premature skin aging, and a greatly increased risk of UV-induced cancers.\"},{\"question\":\"What was unusual about the reported patient’s squamous cell carcinoma case?\",\"answer\":\"The patient developed squamous cell carcinoma at age 55, which is described as unusual due to her extended survival compared with typical expectations.\"},{\"question\":\"How did the clinicians assess ocular photosensitivity in this case?\",\"answer\":\"Ocular photosensitivity was quantified using a standardized UV provocation test, with grading based on erythema after simulated sunlight exposure.\"}]","The Price of Exposure - Xeroderma Pigmentosum and Skin Cancer | PDF",1790199791,13]