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A narrative review consolidates evidence for a preventive role, particularly in early disease stages, by suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and supporting clearance of HPV-dependent lesions. Optimal vitamin D status may prevent and regress LSIL, while vitamin D alone or with chemotherapy shows limited efficacy in established advanced disease.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-preventive-role-of-the-vitamin-d-endocrine-system-in-cervical-cancer/381167/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-preventive-role-of-the-vitamin-d-endocrine-system-in-cervical-cancer/381167.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the proposed preventive role of the vitamin D endocrine system in cervical cancer?","Question",{"text":112,"@type":113},"The review proposes that vitamin D can act in early phases by suppressing proliferation, promoting apoptosis, modulating inflammatory responses, and favoring clearance of HPV-dependent lesions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does vitamin D status relate to low-grade cervical lesions?",{"text":117,"@type":113},"Optimal vitamin D status is associated with prevention and regression of low-grade squamous intraepithelial lesions (LSIL) of the cervix.",{"name":119,"@type":110,"acceptedAnswer":120},"Why might vitamin D be less effective in advanced established cervical cancer?",{"text":121,"@type":113},"The review states that vitamin D alone or combined with chemotherapeutic agents shows little effectiveness once advanced cervical cancer is established.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381167,1790779602,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Review  \nThe Preventive Role of the Vitamin D Endocrine System in Cervical Cancer  \nEuclides Avila 1, *, Bryan Javier Noriega-Mej½a 1, Jocelyn Gonz¡lez-Mac½as 1, Ulises Cortes-Hern¡ndez 1, Janice Garc½a-Quiroz 1, Roc½o Garc½a-Becerra 2 and Lorenza D½az 1  \nCitation: Avila, E.; Noriega-Mejía, B.J.; González-Macías, J.;  \nCortes-Hernández, U.; García-Quiroz, J.; García-Becerra, R.; Díaz, L. The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer. Int. J. Mol. Sci. 2023, 24, 8665 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms24108665  \nAcademic Editor: Bastian Czogalla  \nReceived: 29 March 2023  \nRevised: 8 May 2023  \nAccepted: 10 May 2023  \nPublished: 12 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Departamento de Biolog½a de la Reproducciân Dr. Carlos Gual Castro, Instituto Nacional de Ciencias M²dicas y Nutriciân Salvador Zubir¡n, Av. Vasco de Quiroga No. 15, Col. Belisario Dom½nguez Secciân XVI, Tlalpan,  \nCiudad de M²xico 14080, Mexico; [javiernoriegaxd@gmail.com](javiernoriegaxd@gmail.com) (B.J.N.-M.); [jgm9807@gmail.com](jgm9807@gmail.com) (J.G.-M.);  \n[ulisescortesqfb@gmail.com](ulisescortesqfb@gmail.com) (U.C.-H.); [janice.garciaq@incmnsz.mx](janice.garciaq@incmnsz.mx) (J.G.-Q.); [lorenza.diazn@incmnsz.mx](lorenza.diazn@incmnsz.mx) (L.D.)  \n2 Departamento de Biolog½a Molecular y Biotecnolog½a, Instituto de Investigaciones Biom²dicas, Universidad Nacional Autânoma de M²xico, Av. Universidad 3000, Coyoac¡n, Ciudad de M²xico 04510, Mexico; [rocio.garciab@iibiomedicas.unam.mx](rocio.garciab@iibiomedicas.unam.mx)  \n* Correspondence: [euclides.avilac@incmnsz.mx](euclides.avilac@incmnsz.mx)  \nAbstract: Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human cancers, including cervical cancer. Several studies have found an inverse relationship between the incidence of cervical neoplasia and vitamin D levels. This narrative review updates the current evidence supporting the notion that the vitamin D endocrine system has a preventive role on cervical cancer, mainly in the early phases of the disease, acting at the level of suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and probably favoring the clearance of human papillomavirus-dependent cervical lesions. Although an optimal vitamin D status helps in the prevention and regression of low-grade squamous intraepithelial lesions of the cervix, it appears that vitamin D alone or combined with chemotherapeutic agents has little effectivity once advanced cervical cancer is established. These observations suggest that an optimal vitamin D status might exert beneficial actions in the early phases of cervical cancer by preventing its onset and progression.  \nKeywords: vitamin D; human papillomavirus; cervical cancer; calcitriol; women; LSIL  \n1. Introduction  \nCervical cancer remains a major health issue affecting middle-aged women in lowincome countries. Worldwide, cervical cancer is the fourth most common neoplasia in women, ranking only after breast cancer, colorectal cancer and lung cancer [1] . An estimated 604,000 new cases of cervical cancer were diagnosed globally in 2020, and about 342,000 women died of metastatic advanced cervical cancer [2] . The prevalence of invasive cervical cancer is the highest in sub-Saharan Africa, which is attributable to a combination of factors including deprivation, lower socioeconomic status and higher gender inequa","cbCaitcPwNXTYUyk","https://ap.wps.com/l/cbCaitcPwNXTYUyk","pdf",1024352,15,"English","# Abstract\n# Introduction\n## Epidemiology and prevention\n## Disease risk factors and progression","[{\"question\":\"What is the proposed preventive role of the vitamin D endocrine system in cervical cancer?\",\"answer\":\"The review proposes that vitamin D can act in early phases by suppressing proliferation, promoting apoptosis, modulating inflammatory responses, and favoring clearance of HPV-dependent lesions.\"},{\"question\":\"How does vitamin D status relate to low-grade cervical lesions?\",\"answer\":\"Optimal vitamin D status is associated with prevention and regression of low-grade squamous intraepithelial lesions (LSIL) of the cervix.\"},{\"question\":\"Why might vitamin D be less effective in advanced established cervical cancer?\",\"answer\":\"The review states that vitamin D alone or combined with chemotherapeutic agents shows little effectiveness once advanced cervical cancer is established.\"}]","The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer | PDF",1790243936,38]