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Evidence from multiple studies supports proton radiation in mitigating treatment-related adverse outcomes in patients with locally advanced breast cancer. This review emphasizes clinical and technical considerations to guide proton radiotherapy delivery for this patient population.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-potential-of-proton-therapy-for-locally-advanced-breast-cancer-clinical-and-technical-considerations/382191/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-potential-of-proton-therapy-for-locally-advanced-breast-cancer-clinical-and-technical-considerations/382191.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What physical property makes proton therapy promising for breast cancer treatment?","Question",{"text":112,"@type":113},"Proton therapy can deposit dose at a known depth and then rapidly fall off distal to the target, producing the Bragg peak effect. This helps spare nearby organs at risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the review connect proton therapy to clinical outcomes in locally advanced breast cancer?",{"text":117,"@type":113},"It cites studies showing proton radiation can mitigate treatment-related sequelae for patients with locally advanced breast cancers. The review focuses on how proton radiotherapy should be delivered using clinical and technical expertise.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is radiotherapy emphasized in breast cancer care?",{"text":121,"@type":113},"Radiotherapy remains fundamental in cancer treatment, with nearly half of patients receiving radiation at some point. For breast cancer specifically, radiotherapy after breast-conserving surgery reduces local recurrence and lowers the breast cancer death rate compared with surgery alone.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382191,1790678467,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Review  \nThe Potential of Proton Therapy for Locally Advanced Breast Cancer: Clinical and Technical Considerations  \nN. Lalani 1,*, S. Alqarni 1 and R. B. Jimenez 2  \nCitation: Lalani, N.; Alqarni, S.; Jimenez, R.B. The Potential of Proton Therapy for Locally Advanced Breast Cancer: Clinical and Technical Considerations. Curr. Oncol. 2023, 30, 2869–2878. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)curroncol30030219  \nReceived: 2 February 2023  \nRevised: 16 February 2023  \nAccepted: 22 February 2023  \nPublished: 28 February 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Radiation Oncology, The Irving Greenberg Family Cancer Centre, Ottawa, ON K2H 8P4, Canada  \n2 Department of Radiation Oncology, The Massachusetts General Hospital, Boston, MA 02114, USA  \n* [Correspondence: nlalani@toh.ca](Correspondence: nlalani@toh.ca)  \nAbstract: Proton therapy is a promising therapeutic modality with unique physical properties that allow for abrupt dose fall-off distal to the target of interest, thereby sparing nearby organs at risk. A number of studies have identified the utility of proton radiation in mitigating treatment related sequelae for patients with locally advanced breast cancers. Thus, in the following review, we highlight clinical and technical considerations for proton radiotherapy delivery in patients with locally advanced breast cancer.  \nKeywords: breast cancer; proton therapy; radiotherapy  \n1. Background  \nOncologic outcomes have improved globally due to major strides across the range of surgery, systemic therapy, radiotherapy and immunotherapy. Radiotherapy continues tobe a fundamental part of cancer care, with nearly 50% of patients undergoing radiation at some point in their cancer journey [1] . Traditional radiotherapy approaches utilize X-ray beams, directing photons to the target site. The precision of photon radiation has improved considerably over recent decades due to various technological advances including intensity modulated radiation therapy (IMRT) and stereotactic and image guided radiation therapy. However, unintentional dose deposition to surrounding organs continues to be a treatmentlimiting factor.  \nProton therapy holds promise in addressing this limitation, due its unique physical properties. The characteristic behaviour of a proton entails the deposition of the treatment dose at a known depth with a subsequent, rapid dose-fall off. This property, termed the“Bragg peak”, has been utilized to treat a variety of precariously located tumours while sparing low doses to normal surrounding tissue (Figure 1) [2,3] . The enthusiasm surrounding proton therapy stems from this ability to elicit abrupt dose fall-off distal to the target of interest, thereby sparing low doses of radiation to nearby organs at risk. The therapeutic use of protons was first proposed in 1946 by Harvard physicist Robert R. Wilson [3] . The first patients were subsequently treated in 1954 at the Lawrence Berkeley Laboratory in Berkeley, California [4] . The MIT-based Harvard Cyclotron Laboratory began treating patients in 1973 with a focus on uveal melanomas, chordomas and chondrosarcomas involving the skull base and cervical spine [5] . These milestones paved the way for the first hospital-based clinical proton treatment centre, which opened its doors in 1990 at the Loma Linda University Medical Centre [6] . Since that time, the favourable outcomes seen with the use of proton therapy has led to a significant increase in uptake worldwide. According to a recent report from the Particle Therapy Cooperative Group, there are currently 121 proton facilities in operation globally, spa","cbCait5y2FcoscoJ","https://ap.wps.com/l/cbCait5y2FcoscoJ","pdf",1384552,"English","# 1. Background\n## Proton therapy physical properties and Bragg peak\n## Historical development of clinical proton treatment\n## Global proton facility adoption and patient uptake\n## Breast cancer burden and role of radiotherapy","[{\"question\":\"What physical property makes proton therapy promising for breast cancer treatment?\",\"answer\":\"Proton therapy can deposit dose at a known depth and then rapidly fall off distal to the target, producing the Bragg peak effect. This helps spare nearby organs at risk.\"},{\"question\":\"How does the review connect proton therapy to clinical outcomes in locally advanced breast cancer?\",\"answer\":\"It cites studies showing proton radiation can mitigate treatment-related sequelae for patients with locally advanced breast cancers. The review focuses on how proton radiotherapy should be delivered using clinical and technical expertise.\"},{\"question\":\"Why is radiotherapy emphasized in breast cancer care?\",\"answer\":\"Radiotherapy remains fundamental in cancer treatment, with nearly half of patients receiving radiation at some point. For breast cancer specifically, radiotherapy after breast-conserving surgery reduces local recurrence and lowers the breast cancer death rate compared with surgery alone.\"}]","The Potential of Proton Therapy for Locally Advanced Breast Cancer: Clinical and Technical Considerations | PDF",1790249471,25]