[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329352-105":59,"doc-detail-329352-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","the-potential-clinical-value-of-platelet-aggregation-in-colorectal-tumor-progression-research-findings","The potential clinical value of platelet aggregation in colorectal tumor progression - Research findings","","The study examines whether platelet aggregation function, platelet count, and mean platelet volume serve as indicators related to clinicopathological characteristics in colorectal cancer. A total of 546 patients with colorectal tumors and 118 healthy controls were enrolled and categorized by malignancy, prognosis, recurrence, and metastasis. Platelet aggregation parameters included maximum aggregation ratio, average aggregation ratio, and maximum aggregation time, assessed after stimulation with arachidonic acid and, in subsets, with adenosine diphosphate. Receiver operating characteristic analysis evaluated intergroup significance.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-potential-clinical-value-of-platelet-aggregation-in-colorectal-tumor-progression-research-findings/329352/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-potential-clinical-value-of-platelet-aggregation-in-colorectal-tumor-progression-research-findings/329352.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"What conclusion did the study draw about the clinical value of platelet aggregation?","Question",{"text":112,"@type":113},"Correlations between maximum aggregation ratio, average aggregation ratio, and colorectal tumor progression were observed, suggesting a certain clinical value.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},329352,1790240372,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":131,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":41,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Research  \nThe potential clinical value of platelet aggregation in colorectal tumor progression  \nYuyu Chen1 · Guanghua Liu2 · Jialong Yuan3 · Ju Zuo1 · Huan Liu1 · Hao Liu1  \nReceived: 9 July 2024 / Accepted: 14 October 2024  \n© The Author(s) 2024 OPEN  \nAbstract  \nObjective The present study is to examine whether platelet aggregation function, platelet count and mean platelet volume are indicators that related to clinicopathological characteristics of colorectal cancer.  \nMethods A total of 546 patients with colorectal tumors and 118 healthy controls were enrolled, and patients with colorectal tumors were grouped according to malignancy, prognosis, recurrence and metastasis. The parameters of platelet aggregation function included max aggregation ratio, average aggregation ratio and max aggregation time were detected. 546 patients were induced by arachidonic acid, meanwhile, 415 of which were additionally induced by adenosine diphosphate. Of 118 healthy controls, 60 cases were induced by arachidonic acid and 58 cases were induced by adenosine diphosphate. We evaluated the intergroup significance of these indexes by receiver operating characteristic analysis.  \nResults The levels of max aggregation ratio, average aggregation ratio and platelet count were related to progression including cancerization, radical operation and recurrence and metastasis (P \u003C 0.05) . Notably, max aggregation ratioarachidonic acid is the best indicator for predicting these three progressions with the areas under receiver operating characteristic curve of 0.685, 0.652, and 0.649, respectively.  \nConclusion Correlations between max aggregation ratio, average aggregation ratio and colorectal tumor progression were observed with a certain clinical value.  \nKeywords Tumor cell-induced platelet aggregation · Colorectal tumors · Progression · Clinical value  \n1 Introduction  \nColorectal cancer is one of the most common malignant tumors worldwide currently. The 2020 global cancer statistics shows that colorectal cancer ranks third with an incidence of 10.0% among new cancer cases, and second with a mortality of 9.4%, which is next only to lung cancer [1]. Early screening of colorectal cancer and intervention at the progressive phase of precancerous lesions can significantly reduce the mortality rate. At the same time, postoperative recurrent and metastatic colorectal cancer also has a great impact on the survival of patients. Colorectal cancer with metastasis has amore severe prognosis with a 5-year survival rate of 13.1%[2] .  \nYuyu Chen and Guanghua Liu contributed equally to this work.  \n* Yuyu Chen, [yyucn@hotmail.com |](yyucn@hotmail.com |1Department of Clinical Laboratory)[1](yyucn@hotmail.com |1Department of Clinical Laboratory)[Department of Clinical Laboratory](yyucn@hotmail.com |1Department of Clinical Laboratory), The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha 410013, China. 2Laboratory of Hematology, Department of Blood Transfusion, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University), Changsha 410002, China. 3Department of Laboratory Medicine, Xiangya Medical School, Central South University, Changsha 410013, China.  \nDiscover Oncology  \n(2024) 15:632  \n| [https://doi.org/10.1007/s12672-024-01463-6](https://doi.org/10.1007/s12672-024-01463-6)  \nPlatelets can promote tumor invasion and migration, or even facilitate tumors leaving the primary organ and entering the circulatory system via intraperitoneal implantation [3] . Platelet plays an important effect in colorectal cancer via various mechanisms, it gathers along the intestinal epithelium in adenocarcinoma [4]. Platelet adhesion, aggregation, and procoagulant activity are regulated by a platelet-specific receptor Glycoprotein VI [5]. Interaction between platelets and tumor cells can induce epithelial-mesenchymal transition increasing the stemness of colon cancer cells [6]. Addition","cbCaigKTYRubtRph","https://ap.wps.com/l/cbCaigKTYRubtRph","pdf",1934593,12,"English","# Abstract\n# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction\n# Materials and methods\n## Patients","[{\"question\":\"What conclusion did the study draw about the clinical value of platelet aggregation?\",\"answer\":\"Correlations between maximum aggregation ratio, average aggregation ratio, and colorectal tumor progression were observed, suggesting a certain clinical value.\"}]","The potential clinical value of platelet aggregation in colorectal tumor progression - Research findings | PDF",1789983788]