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The review describes how flavopiridol targets CDKs and other kinases, suppressing processes such as cell-cycle progression, apoptosis, tumor proliferation, angiogenesis, metastasis, and inflammation. It further highlights synthetic derivatives that reduce drawbacks of the parent compound while improving CDK inhibitory activity and therapeutic potential against severe human diseases.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-pharmacological-implications-of-flavopiridol-an-updated-overview-review/380666/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-pharmacological-implications-of-flavopiridol-an-updated-overview-review/380666.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is flavopiridol and how is it related to rohitukine?","Question",{"text":112,"@type":113},"Flavopiridol is a flavone and semi-synthetic derivative derived from rohitukine, which comes from the Indian medicinal plant Dysoxylum binectariferum. The review connects its origin to its biological activity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which molecular targets and processes are affected by flavopiridol?",{"text":117,"@type":113},"Flavopiridol shows potential kinase inhibitory activity, particularly against CDKs and other kinases. This inhibition impacts cell-cycle progression, apoptosis, tumor proliferation, angiogenesis, metastasis, and inflammatory processes.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are synthetic derivatives of flavopiridol important?",{"text":121,"@type":113},"Synthetic derivatives address limitations of the parent compound and provide improved CDK inhibitory activity. The review states that these derivatives enhance therapeutic abilities for treating severe human diseases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380666,1790555013,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","molecules   \nReview  \nThe Pharmacological Implications of Flavopiridol: An Updated Overview  \nHemant Joshi 1, Hardeep Singh Tuli 2, Anuj Ranjan 3, Abhishek Chauhan 4, Shafiul Haque 5,6,7, Seema Ramniwas 8, Gurpreet Kaur Bhatia 9 and Divya Kandari 1, *  \nCitation: Joshi, H.; Tuli, H.S.; Ranjan, A.; Chauhan, A.; Haque, S.; Ramniwas, S.; Bhatia, G.K.; Kandari, D. The Pharmacological Implications of Flavopiridol: An Updated Overview. Molecules 2023, 28, 7530 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules28227530  \nAcademic Editors: Irwin Rose Alencar Menezes, Henrique Douglas Melo Coutinho, Almir  \nGonçalves Wanderley and Jaime Ribeiro-Filho  \nReceived: 15 October 2023  \nRevised: 6 November 2023  \nAccepted: 6 November 2023  \nPublished: 10 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India; [hemantjoshibcas@gmail.com](hemantjoshibcas@gmail.com)  \n[2](2 Department of Bio-Sciences and Technology)[ Department of Bio-Sciences and Technology](2 Department of Bio-Sciences and Technology), [Maharishi Markandeshwar Engineering College](Maharishi Markandeshwar Engineering College), [Maharishi](Maharishi)[ ](Maharishi)Markandeshwar (Deemed to Be University), Mullana, Ambala 133207, India; [hardeep.biotech@gmail.com](hardeep.biotech@gmail.com)  \n[3](3 Academy of Biology and Biotechnology)[ Academy of Biology and Biotechnology](3 Academy of Biology and Biotechnology), [Southern Federal University](Southern Federal University), [Stachki 194/1](Stachki 194/1), Rostov-on-Don 344090, Russia; [aranjan@amity.edu](aranjan@amity.edu)  \n4 Amity Institute of Environmental Toxicology Safety and Management, Amity University, Sector 125, Noida 201301, India; [akchauhan@amity.edu](akchauhan@amity.edu)  \n5 Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; shafi[ul.haque@hotmail.com](ul.haque@hotmail.com)  \n6 Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 11022801, Lebanon  \n7 Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 13306, United Arab Emirates  \n8 University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali 140413, India; [seema.ramniwas@gmail.com](seema.ramniwas@gmail.com)  \n9 Department of Physics, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, India; [gurpreet1308@gmail.com](gurpreet1308@gmail.com)  \n* Correspondence: [divya43_sbt@jnu.ac.in or divyakandari13@gmail.com](divya43_sbt@jnu.ac.in or divyakandari13@gmail.com)  \nAbstract: Flavopiridol is a flavone synthesized from the natural product rohitukine, which is derived from an Indian medicinal plant, namely Dysoxylum binectariferum Hiern. A deeper understanding of the biological mechanisms by which such molecules act may allow scientists to develop effective therapeutic strategies against a variety of life-threatening diseases, such as cancer, viruses, fungal infections, parasites, and neurodegenerative diseases. Mechanistic insight of flavopiridol reveals its potential for kinase inhibitory activity of CDKs (cyclin-dependent kinases) and other kinases, leading to the inhibition of various processes, including cell cycle progression, apoptosis, tumor proliferation, angiogenesis, tumor metastasis, and the inflammation process. The synthetic derivatives of flavopiridol have overcome a few demerits of its parent compound. Moreover, these derivatives have much improved CDK-inhibitory activity and therapeutic a","cbCairqk3tsvFhIg","https://ap.wps.com/l/cbCairqk3tsvFhIg","pdf",3344582,27,"English","# Abstract\n# Keywords\n# 1. Introduction\n# Flavopiridol: source and biological rationale\n# Mechanisms: kinase inhibition and downstream effects\n# Therapeutic potential and derivatives","[{\"question\":\"What is flavopiridol and how is it related to rohitukine?\",\"answer\":\"Flavopiridol is a flavone and semi-synthetic derivative derived from rohitukine, which comes from the Indian medicinal plant Dysoxylum binectariferum. The review connects its origin to its biological activity.\"},{\"question\":\"Which molecular targets and processes are affected by flavopiridol?\",\"answer\":\"Flavopiridol shows potential kinase inhibitory activity, particularly against CDKs and other kinases. This inhibition impacts cell-cycle progression, apoptosis, tumor proliferation, angiogenesis, metastasis, and inflammatory processes.\"},{\"question\":\"Why are synthetic derivatives of flavopiridol important?\",\"answer\":\"Synthetic derivatives address limitations of the parent compound and provide improved CDK inhibitory activity. The review states that these derivatives enhance therapeutic abilities for treating severe human diseases.\"}]","The Pharmacological Implications of Flavopiridol: An Updated Overview - Review | PDF",1790241207,68]