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Sequencing data from 33 cancer types in TCGA are analyzed to assess AKR1B10 expression changes and clinical associations using Kaplan–Meier and multiple immune/TME inference algorithms (PURITY, ESTIMATE, TIMER, CIBERSORT). Multiplex immunofluorescence evaluates AKR1B10 and immune cell markers in gastric cancer. AKR1B10 shows high expression in gastrointestinal tissue in healthy donors, with diminished expression in stomach tumors linked to immune infiltration and immune gene expression changes, including increased CD68+ macrophages and decreased CD19+ B cells.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-pan-cancer-landscape-of-aldo-keto-reductase1b10-reveals-that-its-expression-is-diminished-in-gastric-cancer/329661/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-pan-cancer-landscape-of-aldo-keto-reductase1b10-reveals-that-its-expression-is-diminished-in-gastric-cancer/329661.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main research goal about AKR1B10?","Question",{"text":112,"@type":113},"To determine how AKR1B10 is expressed across multiple cancer types and how it relates to tumor microenvironment and immune-related gene expression, especially in gastric cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was AKR1B10 expression and alterations analyzed across cancers?",{"text":117,"@type":113},"Sequencing data from 33 cancer types in TCGA were integrated to examine expression patterns and genetic/epigenetic alterations, and clinical progression associations were assessed using Kaplan–Meier analysis.",{"name":119,"@type":110,"acceptedAnswer":120},"What immune microenvironment changes were observed in gastric cancer?",{"text":121,"@type":113},"As AKR1B10 expression diminished, CD68+ macrophages increased while CD19+ B cells decreased, alongside correlations between AKR1B10 and immune cell infiltrations and immune gene expression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329661,1789996289,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Original Research PUBLISHED 06 December 2024 DOI 10.3389/fimmu.2024.1488042  \nOPEN ACCESS  \nEDITED BY  \nYun Chen,  \nNanjing Medical University, China  \nREVIEWED BY  \nRemya Raja,  \nMayo Clinic Arizona, United States Sreeparna Banerjee,  \nMiddle East Technical University, Türkiye  \n*CORRESPONDENCE  \nGuoqing Li  \n [ligq1970@163.com](ligq1970@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 29 August 2024  \nACCEPTED 18 November 2024  \nPUBLISHED 06 December 2024  \nCITATION  \nWu A, Li H, Gao M, Liang J, Huang J, Farre´s J, Cao D and Li G (2024) The pan-cancer  \nlandscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer.  \nFront. Immunol. 15:1488042 .  \ndoi: 10.3389/fimmu.2024.1488042  \nCOPYRIGHT  \n© 2024 Wu, Li, Gao, Liang, Huang, Farre´s, Cao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer  \nAnqi Wu 1,2†, Hao Li 3†, Mengnan Gao 4†, Juan Liang 4,  \nJiaqi Huang 4, Jaume Farr´es 5, Deliang Cao 6 and Guoqing Li 2,4*  \n1 Department of Clinical Research Center, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China, 2 Hunan Province Key Laboratory of Basic and Clinical Pharmacological Research on Gastrointestinal Tumors, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China, 3 Department of Pathology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China,  \n4 Department of Gastroenterology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China, 5 Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain, 6 Hunan Province Key Laboratory of Cancer Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, University of South China, Hengyang, China  \nIntroduction: Aldo-keto reductase 1B10 (AKR1B10) is a multifunctional enzyme, which is important in cancer development and progression, but the landscape of AKR1B10 in pan-cancers and in tumor microenvironment is unclear.  \nMethod: This study integrated the sequencing data of 33 cancer types, including gastric cancer, from TCGA project to explored the expression pattern and genetic and epigenetic alterations of AKR1B10 . The association of AKR1B10 expression with clinical progression of cancers was evaluated by Kaplan-Meier analysis; the potential role of AKR1B10 in tumor microenvironment (TME) and immune-related gene expression were analyzed by PURITY, ESTIMATE, TIMER and CIBERSORT algorithms. The expression of AKR1B10 and immune cell markers in gastric cancer were evaluated with multiplex immunofluorescence staining.  \nResult: Results indicated that AKR1B10 was highly expressed in the gastrointestinal tract in health donors, but the expression of AKR1B10 was significantly changed inmost of cancer types, which may be ascribed to DNA methylation in its promoter. The AKR1B10 expression in cancers and its value in disease progression was bidirectional and functionally enriched in metabolism in pan-cancers. In tumor microenvironment, AKR1B10 was significantly correlated with immune cell infiltrations and immune gene expression. In the stomach, along with the diminishing of AKR1B10 expression, CD68+ macrophage increased and CD19+ B cell decreased in gastric cancer.  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nDiscussion: These data indicates that AKR1B10 ","cbCaia00tHurYNol","https://ap.wps.com/l/cbCaia00tHurYNol","pdf",13201330,17,"English","# Introduction\n# Method\n# Result\n# Discussion\n# Keywords\n## Materials and immune-cell validation (multiplex immunofluorescence)","[{\"question\":\"What is the main research goal about AKR1B10?\",\"answer\":\"To determine how AKR1B10 is expressed across multiple cancer types and how it relates to tumor microenvironment and immune-related gene expression, especially in gastric cancer.\"},{\"question\":\"How was AKR1B10 expression and alterations analyzed across cancers?\",\"answer\":\"Sequencing data from 33 cancer types in TCGA were integrated to examine expression patterns and genetic/epigenetic alterations, and clinical progression associations were assessed using Kaplan–Meier analysis.\"},{\"question\":\"What immune microenvironment changes were observed in gastric cancer?\",\"answer\":\"As AKR1B10 expression diminished, CD68+ macrophages increased while CD19+ B cells decreased, alongside correlations between AKR1B10 and immune cell infiltrations and immune gene expression.\"}]","The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer | PDF",1789985095,43]