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Although many individuals were partially or fully vaccinated, confirmed Omicron infections exceeded all other variants combined shortly after Omicron emerged. Existing vaccines can reduce severe illness, but are less effective at preventing infection. A booster dose of BNT162b2 or mRNA-1273 is recommended for people >12 years old who received their second dose >5 months earlier, and the review evaluates booster effectiveness, including early boosting and potential value of a fourth dose.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-omicron-variant-wave-where-are-we-now-and-what-are-the-prospects-review-article/436568/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-omicron-variant-wave-where-are-we-now-and-what-are-the-prospects-review-article/436568.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why did Omicron infections surge despite quarantine measures and vaccination?","Question",{"text":112,"@type":113},"The article explains that Omicron BA.2 became dominant even in countries with strict quarantine mandates. It also notes that prior vaccination did not prevent infections from surpassing other variants soon after Omicron emerged.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How effective are current vaccines against Omicron infections and severe illness?",{"text":117,"@type":113},"The vaccines (ChAdOx1-S, BNT162b2, and mRNA-1273) offer protection against severe SARS-CoV-2 disease, but are less effective at preventing Omicron infections.",{"name":119,"@type":110,"acceptedAnswer":120},"Who is recommended to receive a booster dose, and what is the article reviewing?",{"text":121,"@type":113},"A booster of BNT162b2 or mRNA-1273 is recommended for individuals older than 12 years who received their second dose more than 5 months earlier. The review assesses clinical benefits against Omicron and examines whether early booster vaccination helps prevent surges, and it discusses considerations for a possible fourth dose.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436568,1790794351,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nReview ARticle  \nThe Omicron variant wave: Where are we now and what are the prospects?  \nMong-Lien Wanga,b, Yang Lina, Ju-Fen Houc,d, Yi-Ping Yanga, Yueh Chiena, Yi-Chen Sune,f,  \nKung-Hao Lianga, De-Ming Yanga, Tai-Jay Changa, Cheng-Hsien Wuc,g, Shou-Yen Kaoc,g,* , Kai-Feng Hunga,g,*  \naDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bInstitute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cDepartment ofStomatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; dDepartment of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; eCollege of Medicine, Tzu-Chi University, Hualien, Taiwan, ROC; fDepartment of Ophthalmology, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan, ROC; gDepartment of Dentistry, School of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC  \nAbstract: The Omicron variant BA.2 is the dominant form of the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) outbreak in many countries, including those that have already implemented the strictest quarantine mandates that effectively contained the spread of the previous variants. Although many individuals were partially or fully vaccinated, confirmed Omicron infections have far surpassed all other variants combined in just a couple of months since the Omicron variant emerged. The ChAdOx1-S (AstraZeneca), BNT162b2 (Pfizer-BioNTech), and mRNA-1273 (Moderna) vaccines offer protection against the severe illness of SARS-CoV-2 infection; however, these currently available vaccines are less effective in terms of preventing Omicron infections. As a result, a booster dose of BNT162b2 or mRNA-1273 is recommended for individuals >12 years old who had received their second dose of the approved vaccines for >5 months. Herein, we review the studies that assessed the clinical benefits of the booster dose of vaccines against Omicron infections. We also analyzed public data to address whether early booster vaccination effectively prevented the surge of the Omicron infections. Finally, we discuss the consideration of a fourth dose of vaccine as a way to prevent possible upcoming infections.  \nKeywords: BNT162b2; Booster-dose vaccine; mRNA-1273; Omicron variant; SARS-CoV-2  \n1. EMERGENCE OF THE OMICRON VARIANT  \nThe emergence of the SARS-CoV-2 variant Omicron (B.1.1.529) was first reported to the World Health Organization in Southern Africa on November 24, 2021. Ever since the emergence of this variant, the world has been struggling to prevent the outbreak of this variant. The first known confirmed Omicron B.1.1.529 infection was from a specimen collected on November 9, 2021. In late November, cases of Omicron infection started to appear in Europe. At the beginning of December, the Omicron variant was detected in other parts of the world, including North and South America, Oceania, and Asia, and quickly became the dominant variant of the SARS-CoV-2 variant ever since.1 The Omicron variant spread more easily than the earlier variants of  \n* Address correspondence. Dr. Shou-Yen Kao and Dr. Kai-Feng Hung, Department of Medical Research, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail addresses: sykao@vghtpe.gov](ROC. E-mail addresses: sykao@vghtpe.gov). tw (S.-Y. Kao); [g38913008@gm.ym.edu.tw](g38913008@gm.ym.edu.tw) (K.-F. Hung).  \nConflicts of interest: Dr. Shou-Yen Kao, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 135-137.  \nReceived May 8, 2022; accepted June 9, 2022.  \ndoi: 10. 1097/JCMA.0000000000000863.  \nCop","cbCaiqrwu2of7VJ0","https://ap.wps.com/l/cbCaiqrwu2of7VJ0","pdf",450537,"English","# EMERGENCE OF THE OMICRON VARIANT\n# CAN TWO BASAL SHOTS OF VACCINE PREVENT THE OMICRON PANDEMIC?","[{\"question\":\"Why did Omicron infections surge despite quarantine measures and vaccination?\",\"answer\":\"The article explains that Omicron BA.2 became dominant even in countries with strict quarantine mandates. It also notes that prior vaccination did not prevent infections from surpassing other variants soon after Omicron emerged.\"},{\"question\":\"How effective are current vaccines against Omicron infections and severe illness?\",\"answer\":\"The vaccines (ChAdOx1-S, BNT162b2, and mRNA-1273) offer protection against severe SARS-CoV-2 disease, but are less effective at preventing Omicron infections.\"},{\"question\":\"Who is recommended to receive a booster dose, and what is the article reviewing?\",\"answer\":\"A booster of BNT162b2 or mRNA-1273 is recommended for individuals older than 12 years who received their second dose more than 5 months earlier. The review assesses clinical benefits against Omicron and examines whether early booster vaccination helps prevent surges, and it discusses considerations for a possible fourth dose.\"}]","The Omicron variant wave - Where are we now and what are the prospects? - Review Article | PDF",1790678398]