[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331048-105":59,"doc-detail-331048-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-mutual-interplay-between-ntrk-fusion-genes-and-human-papillomavirus-infection-in-cervical-cancer-progression-review","The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression - Review","","Cervical cancer is a major global health problem, and human papillomavirus (HPV) infection accounts for a substantial proportion of cases. Molecular profiling has revealed genomic subtypes, including neurotrophic tropomyosin receptor kinase (NTRK) fusion-positive cervical cancers. Although NTRK fusions and HPV are established risk factors individually, their combined effects on cancer progression remain unclear. This review examines how NTRK-HPV interplay shapes signaling pathways and summarizes clinical features, histopathology, treatments, and follow-up outcomes for these rare, aggressive, treatment-resistant cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-mutual-interplay-between-ntrk-fusion-genes-and-human-papillomavirus-infection-in-cervical-cancer-progression-review/331048/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-mutual-interplay-between-ntrk-fusion-genes-and-human-papillomavirus-infection-in-cervical-cancer-progression-review/331048.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this review?","Question",{"text":112,"@type":113},"The review explores the mutual interplay between NTRK fusion genes and HPV infection in cervical cancer progression, including their combined influence on signaling pathways and related clinical features and outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are NTRK fusion-positive cervical cancers considered clinically challenging?",{"text":117,"@type":113},"They have a distinct tumor microenvironment and do not respond to conventional radiotherapy or chemotherapy, indicating a need for more effective approaches.",{"name":119,"@type":110,"acceptedAnswer":120},"How does NTRK fusion biology connect to downstream signaling in cancer?",{"text":121,"@type":113},"NTRK fusions produce constitutively activated chimeric TRK receptors that can promote invasion, angiogenesis, growth, survival, and activate MAPK and PI3K pathways.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331048,1790709732,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","MOLECULAR AND CLINICAL ONCOLOGY 21: 67, 2024  \nThe mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression (Review)  \nAZIZ UR REHMAN AZIZ, JIANING ZHANG, CHAN ZHANG, XIAOHUI YU and DAQING WANG  \nKey Laboratory for Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women,  \nDalian Women and Children's Medical Group, Dalian, Liaoning 116012, P.R. China  \nReceived April 10, 2024; Accepted June 19, 2024  \nDOI: 10. 3892/mco.2024.2765  \nAbstract. Cervical cancer is a significant global health concern, with a substantial portion of cases attributed to human papillomavirus (HPV) infection . Recent advance‑ ments in molecular profiling have identified distinct subtypes of cervical cancer based on their genomic alterations. One such subgroup is neurotrophic tropomyosin receptor kinase (NTRK) fusion‑positive cervical cancers, characterized by gene fusions involving the NTRK genes . Although both NTRK fusion genes and HPV infections are independently recognized as significant risk factors in cervical cancer, their interplay and mutual effects on cancer progression are not yet fully understood. The present review is the first of its kind to explore the potential interplay between NTRK fusion genes and HPV infections. It surveys in detail how their combined effect can influence the signaling pathways during cervical cancer development and progression. Moreover, the present study discussed the clinical features, histopathological examinations, treatment procedures and follow‑up outcomes of NTRK‑fusion gene‑positive cervical cancer. The present review may help in the understanding of the management and treatment of such rare, lethal and resistant cervical cancers.  \nContents  \n1. Introduction  \n2. NTRK fusion genes  \n3. TRK signaling pathways  \n4. TRK activation in cancer  \nCorrespondence to: Professor Xiaohui Yu or Professor Daqing Wang, Key Laboratory for Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women, Dalian Women and Children's Medical Group, 154 Zhong Shan Road, Xigang, Dalian, Liaoning 116012, P.R. China  \nE‑mail: [yuxiaohui369@163.com](yuxiaohui369@163.com)  \nE‑[mail: WDQ714619@163.com](mail: WDQ714619@163.com)  \nKey words: human papillomavirus, neurotrophic tropomyosin receptor kinase‑fusion genes, cervical cancer, signaling pathways  \n5. TRK fusions oncogenic activation  \n6. Mutations in NTRK fusion gene and drug resistance  \n7. NTRK fusion genes and cervical cancer  \n8. HPV and cervical cancer  \n9. HPV activates the same pathways as NTRK fusion genes  \n10. Conclusion  \n1. Introduction  \nCervical cancer (CC) is one of the most common cancers in women of reproductive age, with 342,000 deaths and 604,000 new cases in 2020. Nearly 90% of these deaths occur in middle‑ and low‑income nations (1) . The primary cause of CC is the chronic persistent infection of high‑risk human papilloma‑ virus (HPV), which is present in over 90% of cases. However, it is important to note that only 1% of high‑risk HPV‑infected women develop CC (2) . This indicates the presence of additional factors, such as gene mutations and chromosome rearrangements, that contribute to the development of CC. Numerous studies have identified genetic alterations, such as mutations and amplifications, that contribute to the oncogenic process in HPV‑positive CC. For example, recent observations have shown that HPV integration leads to various genomic changes in cervical adenocarcinoma (3) . Similarly, a previous study identified the FGFR3‑TACC3 fusion in HPV‑positive CC (4) . Therefore, it is urgent to gain a deeper understanding of new fusion genes responsible for molecular heterogeneity in HPV‑related CC for improved clinical outcomes.  \nThe neurotrophic tyrosine receptor kinase (NTRK) genes encode tropomyosin receptor kinases (TRK). NTRK genes are essential for nerve cell development and function and may fuse with different genes. When NTRK genes fuse, they produce constitutively ","cbCaibMAsAgRsfhQ","https://ap.wps.com/l/cbCaibMAsAgRsfhQ","pdf",3711496,"English","# Introduction\n# NTRK fusion genes\n# TRK signaling pathways\n# TRK activation in cancer\n# TRK fusions oncogenic activation\n# Mutations in NTRK fusion gene and drug resistance\n# NTRK fusion genes and cervical cancer\n# HPV and cervical cancer\n# HPV activates the same pathways as NTRK fusion genes\n# Conclusion","[{\"question\":\"What is the main focus of this review?\",\"answer\":\"The review explores the mutual interplay between NTRK fusion genes and HPV infection in cervical cancer progression, including their combined influence on signaling pathways and related clinical features and outcomes.\"},{\"question\":\"Why are NTRK fusion-positive cervical cancers considered clinically challenging?\",\"answer\":\"They have a distinct tumor microenvironment and do not respond to conventional radiotherapy or chemotherapy, indicating a need for more effective approaches.\"},{\"question\":\"How does NTRK fusion biology connect to downstream signaling in cancer?\",\"answer\":\"NTRK fusions produce constitutively activated chimeric TRK receptors that can promote invasion, angiogenesis, growth, survival, and activate MAPK and PI3K pathways.\"}]","The mutual interplay between NTRK fusion genes and human papillomavirus infection in cervical cancer progression - Review | PDF",1789991353,23]