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This study examined whether oral dysbiotic status modifies the relationship between tooth loss and cognitive performance using 2011–2012 NHANES data. The analysis included 670 adults aged 60+ and assessed cognition through IWR, DWR, AFT, and DSST. Tooth loss was defined as losing 10+ permanent teeth, and dysbiosis by a periodontal-to-healthy bacteria ratio.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-moderating-effects-of-oral-bacteria-on-the-association-between-tooth-loss-and-cognitive-performance/426490/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-moderating-effects-of-oral-bacteria-on-the-association-between-tooth-loss-and-cognitive-performance/426490.png","ImageObject",300,407,{"name":92,"@type":93},"Ben ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What study question does the paper address?","Question",{"text":112,"@type":113},"Whether oral dysbiotic status moderates the association between tooth loss and cognitive performance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were tooth loss and oral dysbiosis defined?",{"text":117,"@type":113},"Tooth loss was defined as loss of 10+ permanent teeth (out of 28). Oral dysbiosis used a dysbiotic index based on the upper tertile of periodontal bacteria relative to healthy bacteria.",{"name":119,"@type":110,"acceptedAnswer":120},"What cognitive outcomes showed a significant interaction?",{"text":121,"@type":113},"A significant interaction between tooth loss and dysbiotic index was found for the Animal Fluency Test (AFT), with approaching significance for combined word recall scores (IWR+DWR).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426490,1791296740,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","362 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1223  \nTHE MODERATING EFFECTS OF ORAL  \nBACTERIA ON THE ASSOCIATION BETWEEN  \nTOOTH LOSS AND COGNITIVE PERFORMANCE  \nHuabin Luo1, Angela Kamer2, Zhijing Xu2, and Bei Wu3,  \n1. East Carolina University, Greenville, North Carolina, United States, 2. New York University, New York, New York, United States, 3. NYU Shanghai, Shanghai, China (People’s Republic)  \nThere is growing evidence that tooth loss is a risk factor for cognitive dysfunction. Oral microbiome may also influence brain health and contribute to cognitive decline. Yet little evidence exists on the potential modifying role of oral microbiome in the relationship between tooth loss and cognitive performance. Using the 2011-2012 National Health and Nutrition Examination Survey data, we investigated the interaction effects between tooth loss and oral dysbiotic status on cognitive performance. The sample included 670 adults aged 60 years or older. Cognitive performance was assessed by the Consortium to Establish a Registry for Alzheimer’s Disease: Immediate Word Recall (IWR), Delayed Recall (DWR), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST) . Significant tooth loss was defined as a loss of 10+ permanent teeth (out of 28) . A high dysbiotic index (DI) was defined by the upper tertile of the ratio of periodontal bacteria (Treponema, Porphyromonas, and Tannerella) to healthy bacteria (Rothia and Corynebacterium) .  \nMultivariate regression model results showed a significant interaction between tooth loss and the DI (b=-1 .76, P = 0 .04) on AFT; this interaction was approaching significance for word recall test scores (sum of IWR and DWR) (b=-1 .67, P = 0 .07) . This interaction was due to the significant difference in cognitive performance between low and high DI at low tooth loss but not at significant tooth loss. At low tooth loss, cognitive dysfunction is driven by high load of periodontal bacteria. Oral health awareness and good oral hygiene practice should be further promoted among older adults in the community.","cbCaiiszRtIqOn0P","https://ap.wps.com/l/cbCaiiszRtIqOn0P","pdf",364612,"English","# Study Background\n## Methods and Measurements\n## Results and Interpretation\n## Implications","[{\"question\":\"What study question does the paper address?\",\"answer\":\"Whether oral dysbiotic status moderates the association between tooth loss and cognitive performance.\"},{\"question\":\"How were tooth loss and oral dysbiosis defined?\",\"answer\":\"Tooth loss was defined as loss of 10+ permanent teeth (out of 28). Oral dysbiosis used a dysbiotic index based on the upper tertile of periodontal bacteria relative to healthy bacteria.\"},{\"question\":\"What cognitive outcomes showed a significant interaction?\",\"answer\":\"A significant interaction between tooth loss and dysbiotic index was found for the Animal Fluency Test (AFT), with approaching significance for combined word recall scores (IWR+DWR).\"}]","THE MODERATING EFFECTS OF ORAL BACTERIA ON THE ASSOCIATION BETWEEN TOOTH LOSS AND COGNITIVE PERFORMANCE | PDF",1790640723]