[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330764-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330764-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-microrna-let-7-and-its-exosomal-form-epigenetic-regulators-of-gynecological-cancers","The microRNA Let-7 and its exosomal form - Epigenetic regulators of gynecological cancers","","Gynecological cancers (GC) often remain asymptomatic until advanced stages, leading to late diagnosis and limited therapeutic effectiveness. Research increasingly examines microRNAs as regulators of cancer development and as targets for improved detection and treatment. MicroRNAs are small RNAs that modulate gene expression post-transcriptionally, with downregulation frequently observed in human malignancies. Let-7 can control cellular processes and signaling cascades, while increasing its expression may offer treatment potential, aided by exosome-mediated transfer of microRNAs between cells.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-microrna-let-7-and-its-exosomal-form-epigenetic-regulators-of-gynecological-cancers/330764/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-microrna-let-7-and-its-exosomal-form-epigenetic-regulators-of-gynecological-cancers/330764.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is there a need for more efficient diagnosis and treatment for gynecological cancers?","Question",{"text":63,"@type":64},"GCs are often silent until they reach advanced stages, resulting in diagnoses that are too late for effective treatment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do microRNAs, including Let-7, contribute to cancer development?",{"text":68,"@type":64},"MicroRNAs regulate gene expression post-transcriptionally. Many miRNAs are downregulated in malignancies, and Let-7 can influence cellular processes and signaling cascades linked to cancer biology.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the role of exosomes in communicating microRNAs such as Let-7?",{"text":72,"@type":64},"Exosomes are small vesicles traveling through body fluids and can carry components like miRNAs, enabling communication between cells. Evidence links exosome activity to tumor growth, angiogenesis, chemoresistance, metastasis, and immune evasion in GC.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330764,1791189271,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Cell Biol Toxicol (2024) 40:42  \n[https://doi.org/10.1007/s10565-024-09884-3](https://doi.org/10.1007/s10565-024-09884-3)  \nThe microRNA Let‑7 and its exosomal form: Epigenetic regulators of gynecological cancers  \nFei Wang · Chundi Zhou · Yanping Zhu ·  \nMaryam Keshavarzi  \nReceived: 31 January 2024 / Accepted: 15 May 2024 / Published online: 5 June 2024 © The Author(s) 2024  \nAbstract Many types of gynecological cancer (GC) are often silent until they reach an advanced stage, and are therefore often diagnosed too late for effective treatment. Hence, there is a real need for more efficient diagnosis and treatment for patients with GC. During recent years, researchers have increasingly studied the impact of microRNAs cancer development, leading to a number of applications in detection and treatment. MicroRNAs are a particular group of tiny RNA molecules that regulate regular gene expression by affecting the translation process. The downregulation of numerous miRNAs has been observed in human malignancies. Let-7 is an example of a miRNA that controls cellular processes as well as signaling cascades to affect post-transcriptional gene expression. Recent research supports the hypothesis that enhancing let-7 expression in those cancers where it is downregulated may be a potential treatment option. Exosomes are tiny vesicles that move through body fluids and can include components like miRNAs (including let-7) that are important for communication between cells. Studies proved that  \nF. Wang · C. Zhou · Y. Zhu (*)  \nHaiyan People’s Hospital, Zhejiang Province, Jiaxing 314300, Zhejiang, China  \ne-mail: [a154210891@163.com](a154210891@163.com)  \nM. Keshavarzi (*)  \nSchool of Medicine, Tehran University of Medical Sciences, Tehran, Tehran, Iran [e-mail: Kheshavarzi.m124@gmail.com](e-mail: Kheshavarzi.m124@gmail.com)  \nexosomes are able to enhance tumor growth, angiogenesis, chemoresistance, metastasis, and immune evasion, thus suggesting their importance in GC management.  \nKeywords MicroRNA · Let-7 · Gyncological cancer · Cervical cancer · Ovarian cancer · Endometrial cancer  \nIntroduction  \nGynecological cancers (GC) account for 12% of female cancers (Rema 2019) . Gynecological cancers refer to cancers that originate in or spread to different organs related to reproduction, including the cervix, ovaries, uterus or endometrium, vagina, and vulva. GC generally develops in female reproductive organs situated within the pelvis. Each type of GC will have its own distinctive clinical presentation and susceptibility to certain genetic, environmental and lifestyle factors. GC becomes more common as women become older. In America, GCs affect over 90,000 women annually, and more than 28,000 of them die from the disease (Bourla and Zamarin 2016) . The most common GCs, including ovarian, cervical, and endometrial malignancies are major concerns in women’s health throughout the world (Zhang et al. 2019 ; Tian et al. 2021 ; Sun et al. 2021) . Breast cancer is responsible for 32% of all cases among women. The predicted numbers of new cases and fatalities  \nfor breast cancer were determined to be 310,720 and 42,250, respectively. Despite being largely avoidable, cervical cancer is persistently responsible for the second highest number of women’s deaths due to cancer, specifically in the age range of 20 to 39. This concerning trend has emerged in recent years and catapulted cervical cancer to the status of being the third most widespread cause of death in the young female population (Siegel et al. 2024) . Although endometrial cancer (EC) is more common, the deadliest form of GC is ovarian cancer (OC) (Collins et al. 2014), and overall GC death rates are rising despite modern advances in diagnosis and treatment (Bourla and Zamarin 2016) . The significant number of deaths related to GC emphasizes the urgency of conducting more studies and advancements in identifying it at an early stage and enhancing treatment options for latestage GC.  \nMicroRNAs (miR","cbCaicjD720wowVu","https://ap.wps.com/l/cbCaicjD720wowVu","pdf",1645493,41,"English","# Introduction\n## MicroRNAs and Let-7 in cancer biology\n## Exosomes and their role in GC management\n## Gynecological cancer burden and clinical challenges","[{\"question\":\"Why is there a need for more efficient diagnosis and treatment for gynecological cancers?\",\"answer\":\"GCs are often silent until they reach advanced stages, resulting in diagnoses that are too late for effective treatment.\"},{\"question\":\"How do microRNAs, including Let-7, contribute to cancer development?\",\"answer\":\"MicroRNAs regulate gene expression post-transcriptionally. Many miRNAs are downregulated in malignancies, and Let-7 can influence cellular processes and signaling cascades linked to cancer biology.\"},{\"question\":\"What is the role of exosomes in communicating microRNAs such as Let-7?\",\"answer\":\"Exosomes are small vesicles traveling through body fluids and can carry components like miRNAs, enabling communication between cells. Evidence links exosome activity to tumor growth, angiogenesis, chemoresistance, metastasis, and immune evasion in GC.\"}]","The microRNA Let-7 and its exosomal form - Epigenetic regulators of gynecological cancers | PDF",1789989981,103]