[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-368144-105":59,"doc-detail-368144-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","the-microenvironment-cell-index-is-a-novel-indicator-for-the-prognosis-and-therapeutic-regimen-selection-of-cancers-abstract","The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers - Abstract","","Background, methods, results, and conclusions describe a prognostic framework using microenvironment cells (MCs) infiltration for triple-negative breast cancer (TNBC). The study quantifies cellular components from bulk RNA-seq with the xCell algorithm, constructs a microenvironment cell index (MCI) via LASSO-Cox regression, and verifies MCI using scRNA-seq, spatially resolved transcriptomics, and multiplex immunofluorescence. An MCI-enhanced model improves prognosis prediction by integrating spatial distribution of six MC types, and insulin signaling pathway inhibition in MCIhigh TNBC prolongs survival in tumor-bearing mice.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-microenvironment-cell-index-is-a-novel-indicator-for-the-prognosis-and-therapeutic-regimen-selection-of-cancers-abstract/368144/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-microenvironment-cell-index-is-a-novel-indicator-for-the-prognosis-and-therapeutic-regimen-selection-of-cancers-abstract/368144.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"What therapeutic insight does the study provide for MCIhigh TNBC?","Question",{"text":112,"@type":113},"Inhibition of the insulin signaling pathway activated in cancer cells from MCIhigh TNBC patients significantly prolongs survival in tumor-bearing mice.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},368144,1791084314,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":131,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":26},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Yang et al. Journal of Translational Medicine (2025) 23:61  \n[https://doi.org/10.1186/s12967-024-05950-w](https://doi.org/10.1186/s12967-024-05950-w)  \nJournal of Translational Medicine  \n RESEARCH Open Access  \nThe microenvironment cell index is a novel   indicator for the prognosis and therapeutic regimen selection of cancers  \nXian-Yan Yang1,3,4,5†, Nian Chen1,3,4†, Qian Wen1,3,4, Yu Zhou1,3,4, Tao Zhang1,3,4, Ji Zhou1,3,4, Cheng-Hui Liang 1,3,4, Li-Ping Han 1,3,4, Xiao-Ya Wang1,3,4, Qing-Mei Kang 1,3,4, Xiao-Xia Zheng1,3,4, Xue-Jia Zhai 1,3,4, Hong-Ying Jiang1,3,4, Tian-Hua Shen 1,3,4, Jin-Wei Xiao 1,3,4, Yu-Xin Zou 1,3,4, Yun Deng1,3,4, Shuang Lin2, Jiang-Jie Duan 1,3,4,5, Jun Wang1,3,4,5* and Shi-Cang Yu1,2,3,4,5*  \nAbstract  \nBackground It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC) .  \nMethods The xCell algorithm was used to quantify the cellular components oftheTNBC microenvironment based on bulk RNA sequencing (bulk RNA-seq) data. The MCs index (MCI) was constructed using the least absolute shrinkage and selection operator Cox (LASSO-Cox) regression analysis. Single-cell RNA sequencing (scRNA-seq), spatially resolved transcriptomics (SRT), and multiplex immunofluorescence (mIF) staining analyses verified MCI. The mechanism of action of the MCI was investigated in tumor-bearing mice.  \nResults MCI consists of the six types of MCs, which can precisely predict the prognosis oftheTNBC patients. scRNAseq, SRT, and mIF analyses verified the existence and proportions of these cells. Furthermore, combined with the spatial distribution characteristics of the six types of MCs, an MCI-enhanced (MCI-e) model was constructed, which could predict the prognosis oftheTNBC patients more accurately. More importantly, inhibition of the insulin signaling pathway activated in the cancer cells of the MCIhigh theTNBC patients significantly prolonged the survival time of tumorbearing mice.  \nConclusions Overall, our results demonstrate that MCs infiltration can be exploited as a novel indicator for the prognosis and therapeutic regimen selection oftheTNBC patients.  \nKeywords Triple-negative breast cancer, Tumor microenvironment, Cell infiltration, Spatial location, Prognosis prediction, Therapeutic regimen  \n†Xian-Yan Yang and Nian Chen contributed equally to this study.  \n*Correspondence: Jun Wang [wangjun@tmmu.edu.cn](wangjun@tmmu.edu.cn)[ ](wangjun@tmmu.edu.cn)Shi-CangYu [yushicang@tmmu.edu.cn](yushicang@tmmu.edu.cn)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.)  \nYang et al. Journal of Translational Medicine (2025) 23:61  \nBackground  \nTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). TNBC is char","cbCaigdaLZL8Beno","https://ap.wps.com/l/cbCaigdaLZL8Beno","pdf",18504525,24,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Background\n## TNBC characteristics and tumor microenvironment role\n## Immune and cellular infiltration features","[{\"question\":\"What therapeutic insight does the study provide for MCIhigh TNBC?\",\"answer\":\"Inhibition of the insulin signaling pathway activated in cancer cells from MCIhigh TNBC patients significantly prolongs survival in tumor-bearing mice.\"}]","The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers - Abstract | PDF",1790175274]