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This study examines whether anxiety and depression symptoms mediate the association between ADHD symptoms and polysubstance use. Using i-Share cohort data from 1675 French university students (February 2013–July 2020), ADHD symptoms were measured at Time 1, anxiety via STAI-Y trait and depression via PHQ-9 at Time 2, and substance use at Time 3. Structural equation mediation modeling was applied.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-mediating-role-of-anxiety-and-depression-symptoms-in-the-relationship-between-adhd-symptoms-and-polysubstance-use-among-french-university-students-the-i-share-study/439818/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-mediating-role-of-anxiety-and-depression-symptoms-in-the-relationship-between-adhd-symptoms-and-polysubstance-use-among-french-university-students-the-i-share-study/439818.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-29",true,{"@type":101,"interactionType":102,"userInteractionCount":14},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the main objective of the i-Share study described here?","Question",{"text":111,"@type":112},"To determine whether anxiety and depression symptoms mediate the relationship between ADHD symptoms and polysubstance use among French university students.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How were ADHD symptoms, anxiety, depression, and substance use measured across the study timeline?",{"text":116,"@type":112},"ADHD symptoms were assessed at Time 1 using the Adult ADHD Self-Report Scale. Anxiety and depression were evaluated at Time 2 using STAI-Y trait and PHQ-9, respectively. Substance use was assessed at Time 3 using a self-reported questionnaire.",{"name":118,"@type":109,"acceptedAnswer":119},"What did the mediation analysis find about the roles of anxiety and depression?",{"text":120,"@type":112},"The effects through anxiety and depression factors were negative partial mediators, while the total effect between ADHD symptoms and polysubstance use remained positive and significant.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},439818,1790716324,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":143},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Addictive Behaviors Reports 23 (2026) 100652  \nContents lists available at ScienceDirect Addictive Behaviors Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/abrep)[ www.elsevier.com/locate/abrep](homepage: www.elsevier.com/locate/abrep)  \n| The mediating role of anxiety and depression symptoms in the relationship between ADHD symptoms and polysubstance use among French university students: the i-share study\u003Cbr>François A.M. Jean a,b,c,d , Charline Galesnec,d , Noelia Retuertoc,d , Marie C. Navarro c,d, Zeineb Azouza, Agathe Tabyaouia, M´elissa Macalli c,d, Christophe Tzourio c,d,e,\u003Cbr>C´edric Gal´era c,d,f,*\u003Cbr>a Dr Jean Eric Techer Hospital, Department of Child and Adolescent Psychiatry, Calais, France\u003Cbr>b Lille Neuroscience et Cognition, UMR1172, BEEP Team, Platform Cure, National Institute of Health and Medical Research (Institut national de la sant´e et de la recherche m´edicale-INSERM), Lille, France\u003Cbr>c University of Bordeaux, Bordeaux, France\u003Cbr>d Bordeaux Population Health Research Center, UMR1219, HEALTHY Team, National Institute of Health and Medical Research (Institut national de la sant´e et de la recherche m´edicale-INSERM), Bordeaux, France\u003Cbr>e Teaching Hospital of Bordeaux (Centre Hospitalier Universitaire de Bordeaux), Bordeaux, France f Charles Perrens Hospital, Department of Child and Adolescent Psychiatry, Bordeaux, France |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Attention deficit hyperactivity disorder Polysubstance use\u003Cbr>Depression Anxiety Mediation |  | Introduction: Polysubstance use, depressive disorder, and anxiety disorder are frequent comorbidities in adults with ADHD. This study aimed to explore the mediation role of anxiety and depression symptoms in the association between ADHD symptoms and polysubstance use.\u003Cbr>Methods: The study included 1675 French university students from February 2013 to July 2020 as part of the iShare cohort. Time 1: ADHD symptoms were assessed using the Adult ADHD Self-Report Scale. Time 2: Anxiety and depression symptoms were evaluated using the State-Trait Anxiety Inventory-Y trait and the Patient Health Questionnaire-9, respectively. Time 3: Substance use was assessed through a self-reported questionnaire. We conducted a mediation analysis using structural equation modeling.\u003Cbr>Results: The study included 1675 participants. At time 1, the level of ADHD symptoms was moderate (m: 10.66, sd: 3.99). At time 2, both anxiety (m: 47.11, sd: 10.57) and depression (m: 6.92, sd: 5.33) symptoms were moderate. At time 3, 93.49%(1566) of participants had used substances. The direct effect between ADHD factor and polysubstance use factor was of 1.66 (1.04–2.48). The indirect effects between ADHD factor and polysubstance use factor were through anxiety factor − 0.68 ( − 1.15 to − 0.37) and through depression factor − 0.57 ( − 0.94 to − 0.32). Although the mediation effects through anxiety and depression factors were negative, the total effect remained positive and significant (0.41 (0.27 to 0.59)).\u003Cbr>Discussion: Anxiety factor and depression factor acted as negative and partial mediators in the association between ADHD factor and polysubstance use factor. |\n\n1 Introduction  \nAttention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder and one of the most frequent mental disorders (GBD 2019 Mental Disorders Collaborators, 2022). Core symptoms of  \nADHD include hyperactivity, attention deficit and impulsivity (American Psychiatric Association, 2022). The prevalence of ADHD in adults is 2,5%(Simon et al., 2009).  \nADHD is characterized by a high rate of psychiatric comorbidities which contribute significantly to the functional impairments associated  \n* Corresponding author at: Pˆole universitaire de psychiatrie de l’enfant et de l’adolescent, Centre hospitalier Charles-Perrens, 146bis, rue L´eo-Saignat, 33076 Bordeaux, France.  \nE-mail address: [cedric.galera@u-bordeaux.fr](cedric.galera@u-bordeaux.","cbCaigsH498uMe6v","https://ap.wps.com/l/cbCaigsH498uMe6v","pdf",840326,"English","# Introduction\n## ADHD and comorbid psychiatric disorders\n## ADHD and substance use as comorbidities\n# Methods\n## Participants and cohort timeline\n## Measures at Time 1, Time 2, and Time 3\n## Mediation analysis approach\n# Results\n## Descriptive symptom levels and substance use prevalence\n## Direct and indirect mediation effects\n## Total effect interpretation\n# Discussion","[{\"question\":\"What is the main objective of the i-Share study described here?\",\"answer\":\"To determine whether anxiety and depression symptoms mediate the relationship between ADHD symptoms and polysubstance use among French university students.\"},{\"question\":\"How were ADHD symptoms, anxiety, depression, and substance use measured across the study timeline?\",\"answer\":\"ADHD symptoms were assessed at Time 1 using the Adult ADHD Self-Report Scale. Anxiety and depression were evaluated at Time 2 using STAI-Y trait and PHQ-9, respectively. Substance use was assessed at Time 3 using a self-reported questionnaire.\"},{\"question\":\"What did the mediation analysis find about the roles of anxiety and depression?\",\"answer\":\"The effects through anxiety and depression factors were negative partial mediators, while the total effect between ADHD symptoms and polysubstance use remained positive and significant.\"}]","The mediating role of anxiety and depression symptoms in the relationship between ADHD symptoms and polysubstance use among French university students: the i-share study | PDF",1790690305,25]