[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-327464-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-327464-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-mechanism-of-usp43-in-the-development-of-tumor-a-literature-review","The mechanism of USP43 in the development of tumor - a literature review","","Protein ubiquitination governs degradation and multiple fundamental cellular programs, making it central to healthy regulation and disease states. Deubiquitinases (DUBs) remove ubiquitin from specific substrates and reshape downstream signaling, which positions them as promising therapeutic targets in oncology. USP43 is one DUB linked to cancer initiation and progression. This review consolidates current evidence on how USP43 contributes to tumor development and assesses small-molecule DUB inhibitors for potential anti-cancer use.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-mechanism-of-usp43-in-the-development-of-tumor-a-literature-review/327464/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-mechanism-of-usp43-in-the-development-of-tumor-a-literature-review/327464.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is ubiquitination important in cellular regulation and cancer?","Question",{"text":63,"@type":64},"Ubiquitination controls protein degradation and key cellular processes. Disruptions in ubiquitination can contribute to cancer development by affecting division, proliferation, and apoptosis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role do deubiquitinases (DUBs) play in disease pathways?",{"text":68,"@type":64},"DUBs reverse ubiquitination by removing ubiquitin chains from target proteins. This can change the stability or activity of proteins and thereby influence signaling and disease progression.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the purpose and scope of the review on USP43?",{"text":72,"@type":64},"The review provides a comprehensive overview of existing evidence linking USP43 to cancer development and progression. It also considers potential small-molecule inhibitors targeting DUBs as candidate anti-cancer therapeutics.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},327464,1790482061,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 7  \nReview  \nThe mechanism of USP43 in the development of tumor: a literature review  \nZiqi Zhao1,*, Meichen Liu2,*, Zhikun Lin1, 7, Mengru Zhu3, Linlin Lv4, Xinqing Zhu5, Rui Fan6, Abdullah Al-Danakh5, Hui He1, Guang Tan1,7  \n1 Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China  \n2 Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China  \n3 Department of Plastic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China  \n4 Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China  \n5 Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116011, China  \n6 Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, National, School of Basic Medical Sciences, Peking University, Beijing 100191, China  \n7 Liaoning Key Laboratory of Molecular Targeted Drugs in Hepatobiliary and Pancreatic Cancer, Dalian 116000, China *Equal contribution  \nCorrespondence to: Hui He, Guang Tan; email: [hehui@dmu.edu.cn](hehui@dmu.edu.cn); [tanguang009@sina.com](tanguang009@sina.com), [https://orcid.org/0009-0004-](https://orcid.org/0009-0004-)[ ](https://orcid.org/0009-0004-)[5583-187X](5583-187X)  \nKeywords: USP43, cancer, deubiquitinase, tumor immune microenvironment  \nReceived: October 19, 2023 Accepted: March 13, 2024 Published: April 8, 2024  \nCopyright: © 2024 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nUbiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This review aims to provide a comprehensive overview of the existing scientific evidence implicating USP43 in cancer development. Additionally, it will investigate potential small-molecule inhibitors that target DUBs that may have the capability to function as anti-cancer medicines.  \nINTRODUCTION  \nMost proteins undergo several modifications after synthesis, encompassing acetylation, methylation, phosphorylation, glycosylation, and ubiquitination [1– 4] . Numerous signaling pathways are influenced by post-translational modification via the ubiquitination mechanism, which regulates target proteins’ location  \nand/or activity. The ubiquitination process relies on three specific enzymes known as Ubiquitin enzymes (UBEs) that facilitate the covalent attachment of ubiquitin molecules to target proteins. Three key enzymes are ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase or E3 ubiquitin ligase (E3) . The target proteins first interact with E1 and E2, then selectively interact with E3 to regulate the  \n6613  \nspecificity of substrates. Different forms of ubiquitination [5, 6], including monoubiquitination, polyubiquitination, and branching ubiquitination, are essential for intracellular activities and are engaged in various cellular functions [7], such as controlling the cell cycle and responding to DNA damage. Additionally, ubiquitination significantly affects many human diseases by regulating cell division, prolif","cbCaihfvDigo6sHk","https://ap.wps.com/l/cbCaihfvDigo6sHk","pdf",987308,14,"English","# Abstract\n# Introduction\n## Ubiquitination and its key enzymes\n## Deubiquitinating enzymes (DUBs)\n## DUB families with focus on USPs","[{\"question\":\"Why is ubiquitination important in cellular regulation and cancer?\",\"answer\":\"Ubiquitination controls protein degradation and key cellular processes. Disruptions in ubiquitination can contribute to cancer development by affecting division, proliferation, and apoptosis.\"},{\"question\":\"What role do deubiquitinases (DUBs) play in disease pathways?\",\"answer\":\"DUBs reverse ubiquitination by removing ubiquitin chains from target proteins. This can change the stability or activity of proteins and thereby influence signaling and disease progression.\"},{\"question\":\"What is the purpose and scope of the review on USP43?\",\"answer\":\"The review provides a comprehensive overview of existing evidence linking USP43 to cancer development and progression. It also considers potential small-molecule inhibitors targeting DUBs as candidate anti-cancer therapeutics.\"}]","The mechanism of USP43 in the development of tumor - a literature review | PDF",1789977253,35]