[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331359-105":59,"doc-detail-331359-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-l-type-calcium-channel-cav13-a-potential-target-for-cancer-therapy","The L-type calcium channel CaV1.3 - A potential target for cancer therapy","","Cancer remains a major driver of reduced life expectancy, and targeted approaches are central to modern treatment strategies. Calcium (Ca2+) signaling contributes to tumor progression by supporting proliferation, invasion, and distant metastasis, while also shaping therapeutic effectiveness and resistance. This review examines the L-type calcium channel CaV1.3 across different cancer types, emphasizing its therapeutic potential and the rationale for CaV1.3-selective blockers. It summarizes CaV1.3 pharmacology, current development progress, and key challenges and future directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-l-type-calcium-channel-cav13-a-potential-target-for-cancer-therapy/331359/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-l-type-calcium-channel-cav13-a-potential-target-for-cancer-therapy/331359.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is CaV1.3 considered a potential target in cancer therapy?","Question",{"text":112,"@type":113},"CaV1.3 is associated with cancer development and is described as a therapeutic target and prognostic biomarker. The review links calcium signaling to key processes such as proliferation, invasion, metastasis, and treatment resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the focus regarding CaV1.3-selective blockers?",{"text":117,"@type":113},"The review highlights pharmacological properties of CaV1.3 and the current status of developing selective blockers. It also discusses the expectation that these agents could become new cancer drugs.",{"name":119,"@type":110,"acceptedAnswer":120},"What challenges are noted for developing selective CaV1.3 blockers?",{"text":121,"@type":113},"The text states that high amino acid sequence similarity between CaV1.3 and CaV1.2 makes selective blocker development challenging. It also notes that selectivity remains controversial despite reports in the literature.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331359,1790483813,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","DOI: 10. 1111/jcmm.70123  \nRE V I E W  \nThe L-type calcium channel CaV1.3: A potential target for cancer therapy  \nXuerun Liu  | Boqiang Shen | Jingyi Zhou | Juan Hao | Jianliu Wang  \nDepartment of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, China  \nCorrespondence  \nJuan Hao and Jianliu Wang, Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing 100044, China.  \nEmail: [haojuan1023@163.com](haojuan1023@163.com) and [wangjianliu@pkuph.edu.cn](wangjianliu@pkuph.edu.cn)  \nFunding information  \nNational Natural Science Foundation of China, Grant/Award Number: 82230050, 81902635 and 82372621  \nAbstract  \nCancer remains a prominent cause to life expectancy, and targeted cancer therapy stands as a pivotal approach in contemporary therapy. Calcium (Ca2+) signalling plays a multifaceted role in cancer progression, such as proliferation, invasion and distant metastasis. Otherwise, it also exerts an important influence on the efficacy of clinical treatment, including cancer therapy resistance. In this review we discuss the role of the L-type calcium channel CaV1 .3 (calcium voltage-gated channel subunit alpha1 D) in different types of cancers, highlighting its potential as a therapeutic target for certain cancer types. The development of selective blockers of the CaV1 .3 channel has been of great interest and is expected to be a new option for the treatment of cancers such as prostate cancer and endometrial cancer. We present the pharmacological properties of CaV1 .3 and the current status of selective blocker development, and analyse the challenges and possible directions for breakthroughs in the development of tailored medicines.  \nK E Y WO R D S  \nCACNA1D, calcium channel blockers, cancer, L-type calcium channel, targeted therapy  \n1 | INTRODUCTION  \nGlobally, cancer is the leading cause of death and a major obstacle to increasing life expectancy. According to World Health Organization statistics, cancer is the first or second leading cause of death before age 70 in 112 countries worldwide. In 2020, there were about 19.3 million new cancer cases and nearly 10 million cancer deaths worldwide.1 Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11 .7%), but lung cancer remains the leading cause of cancer deaths, with an estimated 1.8 million deaths (18%) .1 Among men, lung cancer is the most common cancer and the leading cause of cancer deaths. Liver cancer and colorectal cancer are the second and third leading causes of cancer deaths in men, respectively. For  \nwomen, breast cancer is the most common cancer and the leading cause of cancer deaths, followed by colorectal and lung cancer for incidence, and vice versa for mortality.1 The economic costs of cancer globally are enormous. It is estimated that from 2020 to 2050, the global economic cost of cancer will be approximately $25.2 trillion, equivalent to a 0 . 55% tax annually.2 With the continuous deepening of research, people have a clearer and clearer understanding of the mechanism of tumorigenesis, and new methods and drugs for the treatment of cancers are emerging, and the cure rate and survival time of cancer patients have been greatly improved. Although a massive amount of work has been done in this area, there is still along way to go to conquer cancers.  \nVoltage-gated calcium channels (VGCCs) are key transducers of membrane potential changes into intracellular calcium transients  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s) . Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nJ Cell Mol Med. 2024;28:e70123 .  \n[https://doi.org/10.1111/jcmm.70123](https://doi.org/10.1111/jcmm.70123)  ","cbCaihDAUeVgU5JR","https://ap.wps.com/l/cbCaihDAUeVgU5JR","pdf",2330613,14,"English","# Introduction\n## Overview of voltage-gated calcium channels and CaV1.3 in cancer\n# Structure and Pathophysiology of CaV1.3\n## Role of CaV1.3 regulation and mechanisms","[{\"question\":\"Why is CaV1.3 considered a potential target in cancer therapy?\",\"answer\":\"CaV1.3 is associated with cancer development and is described as a therapeutic target and prognostic biomarker. The review links calcium signaling to key processes such as proliferation, invasion, metastasis, and treatment resistance.\"},{\"question\":\"What is the focus regarding CaV1.3-selective blockers?\",\"answer\":\"The review highlights pharmacological properties of CaV1.3 and the current status of developing selective blockers. It also discusses the expectation that these agents could become new cancer drugs.\"},{\"question\":\"What challenges are noted for developing selective CaV1.3 blockers?\",\"answer\":\"The text states that high amino acid sequence similarity between CaV1.3 and CaV1.2 makes selective blocker development challenging. It also notes that selectivity remains controversial despite reports in the literature.\"}]","The L-type calcium channel CaV1.3 - A potential target for cancer therapy | PDF",1789992906,35]