[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-543250-105":59,"doc-detail-543250-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-influence-of-a-combination-of-lifestyle-modification-and-a-new-formula-supplement-with-antioxidative-and-antioestrogenic-activity-on-mild-idiopathic-abnormalities-of-semen-parameters-a-pilot-study","The influence of a combination of lifestyle modification and a new formula supplement with antioxidative and antioestrogenic activity on mild idiopathic abnormalities of semen parameters - A pilot study","","Unhealthy lifestyle and environmental factors may influence semen parameters through oxidative stress, functional hypogonadism, and xenobiotics. This pilot study evaluates a diet supplement containing glutathione and herbs with antioxidative and antioestrogenic activity combined with lifestyle improvement. Medical records of 50 men aged 24–52 (median 35) with idiopathic semen-parameter abnormalities were retrospectively analysed. After three months, median serum FSH, LH, and testosterone increased, and all mean semen parameters improved, including total sperm count.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-influence-of-a-combination-of-lifestyle-modification-and-a-new-formula-supplement-with-antioxidative-and-antioestrogenic-activity-on-mild-idiopathic-abnormalities-of-semen-parameters-a-pilot-study/543250/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-influence-of-a-combination-of-lifestyle-modification-and-a-new-formula-supplement-with-antioxidative-and-antioestrogenic-activity-on-mild-idiopathic-abnormalities-of-semen-parameters-a-pilot-study/543250.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-10-11",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To evaluate how combining lifestyle improvement with a diet supplement (glutathione plus antioxidative and antioestrogenic herbs) affects semen parameters in men with idiopathic abnormalities.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Who were the participants and how were they selected?",{"text":117,"@type":113},"The study retrospectively analysed records of 50 men aged 24–52 with idiopathic semen-parameter abnormalities. Inclusion required adequate sperm concentration and specific motility/vitality/morphology disorders, along with good general health and no fertility-affecting diseases or treatments.",{"name":119,"@type":110,"acceptedAnswer":120},"What changes were observed after three months of therapy?",{"text":121,"@type":113},"Median serum FSH increased by 70%, LH by 67%, and testosterone by 79%. Mean semen parameters also improved significantly, including total sperm count increasing by 68%.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},543250,1791915309,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Received: 14 June 2021  \nRevised: 25 September 2021  \nAccepted: 28 September 2021  \nDOI: 10. 1111/and.14279  \nOR I G I NAL ART I C L E  \nThe influence of a combination of lifestyle modification and a new formula supplement with antioxidative and antioestrogenic activity on mild idiopathic abnormalities of semen parameters—A pilot study  \nJolanta Slowikowska-Hilczer1  | Renata Walczak-Jedrzejowska1  | Piotr Dobronski2   \n1Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland 2Department of General, Oncological and Functional Urology, Warsaw Medical University, Warsaw, Poland  \nCorrespondence  \nJolanta Slowikowska-Hilczer, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, 92-213 Lodz, Pomorska 251, Poland.  \nEmail: jolanta. slowikowska-hilczer@umed. [lodz.pl](lodz.pl)  \nFunding information  \nUniwersytet Medyczny w Lodzi, Grant/ Award Number: 503/1-089-03/503-11-001- 19-00  \nAbstract  \nUnhealthy lifestyle and environmental factors may influence semen parameters via oxidative stress, functional hypogonadism and xenobiotics. The aim of the study was to evaluate the influence of a diet supplement containing glutathione and herbs with antioxidative and antioestrogenic activity, in combination with lifestyle improvement, on semen parameters. Data from the medical records of 50 men aged 24–52 (median 35.0) with idiopathic abnormalities in semen parameters were retrospectively analysed. The inclusion criteria comprised sperm concentration >5 mln/ml, disorders in sperm motility and/or vitality and/or morphology, good general health, no present nor previous diseases or treatment which may influence fertility, and normal testicular volume. Patients were advised to change their lifestyle and take the supplement for three months. Basic semen analysis and serum FSH, LH and testosterone levels were performed before and after the prescribed therapy. After three months of treatment, median serum concentrations of FSH significantly increased by 70%, LH by 67% and testosterone by 79%, and all mean semen parameters were significantly increased (total sperm count by 68%) . It seems that lifestyle changes supported by consumption of herbs with antioxidative and antioestrogenic activity may be suitable for the first-line therapy for patients with mild idiopathic abnormalities in semen parameters or serum concentrations of reproductive hormones.  \nK E Y WO R D S  \nhypogonadism, lifestyle, male infertility, oxidative stress, semen parameters  \n1 | INTRODUCTION  \nDisorders of male fertility account for about 50% of infertility reported by couples (Agarwal et al., 2015) . While in some cases, causes of male infertility are known and are treatable, for example hypogonadotropic hypogonadism, urogenital infections and varicocele; a large proportion (30%–50%) of male infertility remains idiopathic (Hamada et al., 2012) . The solution may lie in lifestyle and environmental factors, which may influence general health, semen  \nparameters and spermatozoa function in many ways (Leisegang & Dutta, 2021) .  \nOne such factor is oxidative stress, that is, a potential imbalance between the production and accumulation of reactive oxygen species (ROS) and the ability of a biological system to detoxify them. Numerous studies have shown that ROS can be harmful to spermatogenesis cells and can impair spermatozoa functions (Agarwalet al., 2014; Gharagozloo & Aitken, 2011; Pizzino et al., 2017) . Oxidative stress affects spermatozoa activity, damages DNA  \nAndrologia. 2022;[54:e14279. wileyonlinelibrary.com/journal/and](54:e14279. wileyonlinelibrary.com/journal/and)  \n[https://doi.org/10.1111/and.14279](https://doi.org/10.1111/and.14279)  \n© 2021 Wiley-VCH GmbH  \n1 of 7  \n14390272, 2022, 1, Downloaded from [https://onlinelibrary.wiley.com/doi/10.1111/and.14279 by National Medical Library The Director, Wiley Online Library on [03/11/2022]. See the Terms and Conditions (](https://onlinelibrary.wiley.co","cbCaimr4ocILAmO3","https://ap.wps.com/l/cbCaimr4ocILAmO3","pdf",452578,"English","# Abstract\n## Introduction","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To evaluate how combining lifestyle improvement with a diet supplement (glutathione plus antioxidative and antioestrogenic herbs) affects semen parameters in men with idiopathic abnormalities.\"},{\"question\":\"Who were the participants and how were they selected?\",\"answer\":\"The study retrospectively analysed records of 50 men aged 24–52 with idiopathic semen-parameter abnormalities. Inclusion required adequate sperm concentration and specific motility/vitality/morphology disorders, along with good general health and no fertility-affecting diseases or treatments.\"},{\"question\":\"What changes were observed after three months of therapy?\",\"answer\":\"Median serum FSH increased by 70%, LH by 67%, and testosterone by 79%. Mean semen parameters also improved significantly, including total sperm count increasing by 68%.\"}]","The influence of a combination of lifestyle modification and a new formula supplement with antioxidative and antioestrogenic activity on mild idiopathic abnormalities of semen parameters - A pilot study | PDF",1791758602,18]