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Gut inflammation was framed as a key determinant of health and performance in modern poultry production. The discussion emphasized nutritional drivers of gut integrity and immune activation, including feed components with pro- and anti-inflammatory actions. Dietary fiber, amino acids (threonine, glutamine, arginine), and mineral chelation—especially zinc and copper—were highlighted for their roles in microbial modulation, mucosal repair, mineral bioavailability, and reduced oxidative and inflammatory responses. The symposium concluded with practical, early-intervention feed formulation approaches integrating evidence to optimize gut health and sustainability.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-inflammation-saga-breakthrough-nutritional-insights-for-poultry/413987/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-inflammation-saga-breakthrough-nutritional-insights-for-poultry/413987.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What mechanisms help protect a poultry bird from microbes and toxins in the intestine?","Question",{"text":112,"@type":113},"The intestinal tract includes defense layers such as mucin, tight junction proteins, and the epithelial surface, alongside an immune system that monitors commensal and pathogenic microorganisms and detects pathogen proliferation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does inflammation relate to disrupted intestinal homeostasis in poultry?",{"text":117,"@type":113},"Inflammation is described as a biological reaction to disrupted tissue homeostasis, meant to destroy or isolate the disruption and remove damaged tissue to restore balance, but it can harm the host if excessive or chronic.",{"name":119,"@type":110,"acceptedAnswer":120},"Which nutritional factors were discussed as influencing gut inflammation in poultry?",{"text":121,"@type":113},"The symposium emphasized dietary fiber effects, amino acids including threonine, glutamine, and arginine for mucosal repair and immune modulation, and mineral chelation involving zinc and copper to improve mineral bioavailability while minimizing oxidative and inflammatory responses.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},413987,1790814097,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","105 (2026) 106200  \nContents lists available at ScienceDirect  \nPoultry Science  \njournal [homepage:](homepage: www.elsevier.com/locate/psj)[ www.elsevier.com/locate/psj](homepage: www.elsevier.com/locate/psj)  \n| The inflammation saga: Breakthrough nutritional insights for poultry\u003Cbr>Rajesh Jha a,* , Doug Korverb,c , Woo Kyun Kim d , Leon Marchale , Kirsty Gibbs e , John Halley f\u003Cbr>a University of Hawaii at Manoa, Honolulu, HI, USA b Alpine Poultry Nutrition, Inc., Edmonton, AB, Canada c University of Alberta, Edmonton, AB, Canada d University of Georgia, Athens, GA, USA\u003Cbr>e Danisco Animal Nutrition & Health, IFF, Oegstgeest, the Netherlands f J. Halley Poultry Consulting LLC, Siloam Springs, AR, USA |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: Gut Inflammation Nutrition\u003Cbr>Fiber\u003Cbr>Amino acids Mineral chelation |  | This symposium offered a broader perspective on gut inflammation in poultry. It covered the basic factors that trigger gut inflammation, their potential effects on performance and health, and potential strategies to manage inflammation and mitigate its adverse effects. Gut inflammation has emerged as a critical determinant of health and performance in modern poultry production. A focus was placed on key nutritional factors that influence gut integrity and immune activation, including the pro-and anti-inflammatory roles of specific feed components. The role of dietary fiber was discussed, emphasizing its dualistic effects as both a potential irritant and a modulator of microbial populations and immune functions. The symposium also discussed the roles of amino acids such as threonine, glutamine, and arginine, which aid in mucosal repair and immune modulation. Additionally, the impact of mineral chelation, particularly involving zinc and copper, was discussed in the context of enhancing mineral bioavailability while minimizing oxidative and inflammatory responses. Ultimately, the symposium explored a practical approach to managing gut inflammation in commercial poultry operations, emphasizing the importance of early nutritional interventions and targeted feed formulation and nutrition strategies. Lastly, it was concluded that by integrating current scientific evidence with practical insights, poultry nutritionists and industry stakeholders should employ multiple approaches based on actionable knowledge to optimize gut health and reduce inflammation, thereby enhancing bird performance and the sustainability of the poultry industry. |\n\nNutritional factors of gut inflammation (D. Korver)  \nThe intestinal tract is one of the largest, if not the largest, surface areas exposed to the environment of humans and poultry (Ferrer et al., 2003; Helander and Fandriks, 2014). Although the digestive tract is contained within the body, the lumen is actually outside of the bird. Therefore, although the function of the intestinal tract is usually thought of as being the uptake of nutrients, it has another important function: preventing access of microbes and toxins to the tissues of the bird (Ducatelle et al., 2023). The intestinal tract has multiple layers of defense, including passive mechanisms such as mucin, tight junction proteins, and the epithelial surface. Additionally, the immune system has a large presence in the intestinal tract, monitoring the presence of  \ncommensal and pathogenic microorganisms, and detecting proliferation of potential pathogens within the gut.  \nInflammation is a biological reaction to disrupted tissue homeostasis (Medzhitov, 2008) intended to rapidly destroy or isolate the cause of the disruption, and to remove damaged tissue and restore homeostasis. It is a tissue-destroying process that not only disrupts invading pathogens but can also destroy or impair the function of the host’s own tissues (Ashley et al., 2012). Inflammation is a critical part of the host’s protection from disease. However, it can become harmful to the host when the inflammation becomes ","cbCaikgync7zlKyy","https://ap.wps.com/l/cbCaikgync7zlKyy","pdf",593061,"English","# The inflammation saga: Breakthrough nutritional insights for poultry\n## Nutritional factors of gut inflammation (D. Korver)","[{\"question\":\"What mechanisms help protect a poultry bird from microbes and toxins in the intestine?\",\"answer\":\"The intestinal tract includes defense layers such as mucin, tight junction proteins, and the epithelial surface, alongside an immune system that monitors commensal and pathogenic microorganisms and detects pathogen proliferation.\"},{\"question\":\"How does inflammation relate to disrupted intestinal homeostasis in poultry?\",\"answer\":\"Inflammation is described as a biological reaction to disrupted tissue homeostasis, meant to destroy or isolate the disruption and remove damaged tissue to restore balance, but it can harm the host if excessive or chronic.\"},{\"question\":\"Which nutritional factors were discussed as influencing gut inflammation in poultry?\",\"answer\":\"The symposium emphasized dietary fiber effects, amino acids including threonine, glutamine, and arginine for mucosal repair and immune modulation, and mineral chelation involving zinc and copper to improve mineral bioavailability while minimizing oxidative and inflammatory responses.\"}]","The inflammation saga - Breakthrough nutritional insights for poultry | PDF",1790596317,15]