[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-361832-105":59,"doc-detail-361832-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","the-incidence-of-esophageal-second-primary-cancer-in-head-and-neck-cancer-patients-observational-study","The incidence of esophageal second primary cancer in head and neck cancer patients - Observational Study","","This observational retrospective cohort study evaluates the association between esophageal second primary neoplasm (ESPN) and head and neck cancers (HNC) using panendoscopy findings. The analysis includes 365 eligible HNC patients from 2015–2021 in Linkou Chang Gung Memorial Hospital. ESPN occurred in 37 patients (10.1%) including dysplasia and carcinoma in situ. Alcohol and areca-quid consumption varied significantly by HNC subsite, with hypopharyngeal cancer showing the highest incidence and odds ratio (OR 13.3). Within 24 months, especially 12 months for hypopharyngeal cancer, routine panendoscopy is strongly recommended, with STROBE-aligned reporting.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-incidence-of-esophageal-second-primary-cancer-in-head-and-neck-cancer-patients-observational-study/361832/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-incidence-of-esophageal-second-primary-cancer-in-head-and-neck-cancer-patients-observational-study/361832.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main purpose of the study?","Question",{"text":112,"@type":113},"To investigate the correlation between esophageal second primary neoplasm (ESPN) and head and neck cancers using panendoscopy findings to support timely intervention.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients were included and what time period did the study cover?",{"text":117,"@type":113},"365 HNC patients were enrolled from 2015 to 2021 in Linkou Chang Gung Memorial Hospital.",{"name":119,"@type":110,"acceptedAnswer":120},"Which HNC subsite showed the highest ESPN incidence?",{"text":121,"@type":113},"Hypopharyngeal cancer had the highest ESPN incidence, with the largest odds ratio (OR 13.3, P \u003C .001).",{"name":123,"@type":110,"acceptedAnswer":124},"What did the study suggest about follow-up timing and testing?",{"text":125,"@type":113},"Half of the ESPNs were found within 24 months after HNC diagnosis, so intensive surveys and routine panendoscopy are advised, particularly during the first 24 months and especially for hypopharyngeal cancer.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},361832,1790491705,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":46},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","®  \n Observational Study   \nThe incidence of esophageal second primary cancer in head and neck cancer patients  \nTz-Wei Chiou, MDa , Chi-Kuang Young, MDb ,c , Ken-Hao Hsu, MDb ,c , Chun-Ta Liao, MDb ,c , Yu-Feng Hu, MDb ,c , Chung-Jan Kang, MD, PhDb ,c , Shiang-Fu Huang, MD, PhDb ,d ,*  \n\n| Abstract\u003Cbr>This study aims to investigate the correlation between esophageal second primary neoplasm (ESPN) in head and neck cancers. Panendoscopy findings of ESPN can guide clinicians in timely interventions and improve patients’ outcomes. We performed a retrospective cohort study in Linkou Chang Gung Memorial Hospital, and 365 patients who met the criteria from 2015 to 2021 were enrolled. We collected the lifestyle habits and panendoscopy report after the HNC was diagnosed. Of 365 HNC patients, 37 (10 . 1%) had ESPNs, which included low dysplasia, high dysplasia, squamous cell carcinoma in situ and squamous cell carcinoma. We found that alcohol (P = .004) and areca-quids (AQs) consumption (P = .003) had significant differences in different HNC subsites. Oral cavity cancers had the highest association with alcohol and AQs consumption. Hypopharyngeal cancer has the highest ESPN incidence with highest odds ratio (OR = 13.3, P \u003C .001), followed by oropharynx, larynx, and oral cavity. In addition, we found that alcohol (P = .002) and cigarette consumption (P = .040) were associated with the ESPN development. Other panendoscopy findings such as gastroesophageal reflux disease, esophageal mucosa break, gastritis ulceration, and gastritis showed insignificant correlations with the occurrence of ESPN. Half of the ESPN were found within 24 months after the diagnosis of HNC, especially for hypopharyngeal cancer, in which ESPN even occurs within 12 months of the diagnosis of primary tumor. Routine panendoscopy for patients with HNC is highly advised, and our study suggests having intensive surveys in the first 24 months after the diagnosis of primary HNC; especially for hypopharyngeal cancer. This study was reported in strict compliance with the strengthening the reporting of observational studies in epidemiology (STROBE) guideline. |\n| --- |\n| Abbreviations: AQ = areca quid, CI = confidence interval , EGD = esophagogastroduodenoscopy, ER = endoscopic resection, ESD. = eendoscopic submucosal dissection, ESPNs = esophageal second primary neoplasms, HNC = head and neck cancer, NBI-M = barrow-band imaging with magnification, ORs = odds ratios, WLE = white-light endoscopy. |\n| Keywords: esophageal cancer, head and neck cancer, panendoscopy, secondary primary cancer |\n\n1. Introduction  \nHead and neck cancer (HNC), which includes cancers from the oral cavity, nasopharynx, oropharynx, hypopharynx and larynx, and esophageal cancer are both increasing worldwide in recent years.[1,2] Patients with HNC are also at increased risk of developing second primary tumor, which including the esophageal cancer.[3] This risk of having esophageal cancer after HNC treatments is an 8-fold to 22-fold higher than the general population.[4–6] The second primary tumor development now can be explained by the “field cancerization theory”: Premalignant epithelial changes are caused by repeated exposure to common  \ncarcinogens, such as alcohol, tobacco and areca quid (AQ), which contributes to the development of synchronous or metachronous second primary tumors.[7]  \nIn south Asia, such as Taiwan, the risk factors of HNC with esophageal second primary cancer not only have alcohol and tobacco, but also have AQ chewing.[8] Due to the increased consumption of these carcinogens in recent years, the prevalence of HNC and esophageal cancer gets higher.  \nEsophageal carcinomas are often diagnosed in advanced stages because they can be asymptomatic at the early development.[9] Generally, esophageal cancer at the early stage only can be screened by esophagogastroduodenoscopy (EGD), and  \nThis study was supported by grants CMRPG3M1103 from Chang Gung Memorial Hospital and grant MOST 110-231","cbCaiuLdbiC4b4ld","https://ap.wps.com/l/cbCaiuLdbiC4b4ld","pdf",643718,"English","# Abstract\n# Introduction\n## Background and Rationale\n## Risk Factors and Field Cancerization Theory\n## Screening and Study Context","[{\"question\":\"What was the main purpose of the study?\",\"answer\":\"To investigate the correlation between esophageal second primary neoplasm (ESPN) and head and neck cancers using panendoscopy findings to support timely intervention.\"},{\"question\":\"How many patients were included and what time period did the study cover?\",\"answer\":\"365 HNC patients were enrolled from 2015 to 2021 in Linkou Chang Gung Memorial Hospital.\"},{\"question\":\"Which HNC subsite showed the highest ESPN incidence?\",\"answer\":\"Hypopharyngeal cancer had the highest ESPN incidence, with the largest odds ratio (OR 13.3, P \\u003c .001).\"},{\"question\":\"What did the study suggest about follow-up timing and testing?\",\"answer\":\"Half of the ESPNs were found within 24 months after HNC diagnosis, so intensive surveys and routine panendoscopy are advised, particularly during the first 24 months and especially for hypopharyngeal cancer.\"}]","The incidence of esophageal second primary cancer in head and neck cancer patients - Observational Study | PDF",1790145725]