[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-134845-en":3,"doc-seo-134845-105":31,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":28,"seo_description":14,"update_tm":29,"read_time":30},134845,962075114765,"Quinn","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",8,"Research & Report","The Importance of the Natural - Dissertation - Transmission of Rift Valley Fever Virus for Its Infection in the Mammalian Host","This doctoral dissertation investigates how transmission of Rift Valley Fever Virus enables infection in mammalian hosts. The work is conducted under supervision at the Bernhard Nocht Institute for Tropical Medicine and focuses on understanding viral infection processes using laboratory methodologies relevant to mosquito-virus interaction. Results are organized into a formal academic structure covering introduction, background on RVFV biology, and subsequent experimental chapters, supported by figures, tables, abbreviations, and both English summary and German declaration material.","# The Importance of the Natural\n\nTransmission of Rift Valley Fever Virusfor Its Infection in the Mammalian Host  \n### Dissertation\n\nto obtain the degree Doctor of Philosophy  \nfrom the Faculty of Mathematics, Informatics and Natural SciencesDepartment of BiologyUniversity of Hamburg  \nsubmitted by  \n## András Bencsik\n\nThe present work was performed under the supervision of Prof. Dr. Esther Schnettler and Prof.Dr. César Muñoz-Fontela at the Bernhard Nocht Institute for Tropical Medicine (BNITM) inHamburg.  \nEvaluators  \n##### 1st Reviewer: Prof. Dr. Esther Schnettler\n\nBernhard Nocht Institute for Tropical Medicine  \nResearch Group Mosquito-Virus Interaction  \nBernhard-Nocht-Straße 74, 20359 Hamburg  \n##### 2nd Reviewer: Prof. Dr. Minka Breloer\n\nBernhard Nocht Institute for Tropical Medicine  \nResearch Group Helminth Immunology  \nBernhard-Nocht-Straße 74, 20359 Hamburg  \nDate of oral defence: 05.03.2024  \n#### Eidesstattliche Versicherung - Declaration on oath\n\nHiermit erkläre ich an Eides statt, dass ich die vorliegende Dissertationsschrift selbst verfasstund keine anderen als die angegebenen Quellen und Hilfsmittel benutzt habe.  \nI hereby declare, on oath, that I have written the present dissertation by my own and have notused other than the acknowledged resources and aids.  \nHamburg, den 18.12.2023 Unterschrift/Signature  \nAcknowledgement  \nI would like to thank the following people without whom I would not have been able tocomplete this dissertation. Firstly, I would like to thank all the past and present members ofthe virus immunology and mosquito virus interaction groups at the Bernhard Nocht Institutefor Tropical Medicine. I owe special thanks to my supervisors, Prof. Esther Schnettler, who hashelped me over the years not only with her insightful knowledge but also with her kind andencouraging mentorship, and Prof. César Muñoz-Fontela whose expertise and guidance keptme on track and inspired me to look for the bigger picture. I am eternally grateful to my formermentor Dr. Zoltán Pós; without your teaching in the past, I could never have succeeded in thisproject. I also owe my gratitude to the Joachim Herz Foundation for funding this project.  \nI would like to thank Sergio Gómez Medina for the BSL-3 training and Dr. Mayke Leggewie andDr. Mine Altinli for showing me how to work with mosquitoes. I owe my gratitude to Dr. DánielCadar for his help with the sequencing, and to Dr. Susanne Krasemann for preparing thehistology sections.  \nI would like to thank Dr. Catherine Awuor Olal for encouraging me to pursue experiments I hadgiven up on before even trying, also for her input and moral support together with Dr. EmilyNelson and Monika Rottstegge. Your friendship helped me to see this through to the end.  \nI am thankful to Pedro Neira for always helping me with my molecular biology questions, andto Dr. Beatriz Escudero-Pérez for her help with the TVAs and for training me for BSL-4 work.Thank you to all the Herzis for helping me navigate life in Germany and, most importantly, forall the great times we have spent together.  \nI would like to thank my friends in Hungary, Barbara Gellén, Dr. Barbara Molnár-Érsek, KrisztiánTóth and Dr. Erik Zajta for their endless effortsto remain my friends despite the great distancesthis project has created between us. Your support meant a lot to me while I was so far fromhome. Of course, I would like to thank my family. Köszönöm, hogy hittetek bennem és erőtökönfelül támogattatok ezen a hosszú és embert próbáló úton!  \nFinally, and most importantly, to my partner, Matthijs Van Daele, for being my rock and solidground during these difficult years. Thank you for your love, your support and the sacrificesyou have made, enabling me to pursue my calling. I could not have done it without you.  \nTable of contents  \nEIDESSTATTLICHE VERSICHERUNG - DECLARATION ON OATH ............................................... I  \nACKNOWLEDGEMENT .........................................................................","cbCaihI7olbriWOD","https://ap.wps.com/l/cbCaihI7olbriWOD","pdf",16871403,4,1,123,"English","en",105,"# Introduction\n## Rift Valley Fever Virus\n### Taxonomy\n### Ecology and veterinary relevance\n### RVFV in humans\n### Molecular biology of RVFV\n#### Virion structure\n#### Genome organization\n#### Functions of viral proteins\n## Therapy","[{\"question\":\"What topic does the dissertation focus on?\",\"answer\":\"The dissertation focuses on the importance of transmission of Rift Valley Fever Virus for establishing infection in mammalian hosts.\"},{\"question\":\"Where was the dissertation carried out?\",\"answer\":\"The work was performed at the Bernhard Nocht Institute for Tropical Medicine (BNITM) in Hamburg under the supervision of listed professors.\"},{\"question\":\"How is the research organized in the thesis?\",\"answer\":\"The thesis includes front matter such as declaration on oath, acknowledgements, lists of figures and tables, abbreviations, and then a structured introduction with subsections on RVFV biology.\"}]","The Importance of the Natural - 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