[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336396-105":59,"doc-detail-336396-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-importance-of-intestinal-microbiota-and-dysbiosis-in-the-context-of-the-development-of-intestinal-lymphoma-in-dogs-and-cats","The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats","","Recent advances deepen understanding of how animal microbiomes shape veterinary health, particularly in the complex intestinal ecosystem. Microbial dysbiosis—an imbalance in gut microorganisms—can provoke inflammatory events in the intestinal mucosa and disrupt immune homeostasis. These processes increase vulnerability to toxins and metabolites and support carcinogenic pathways leading to intestinal lymphoma. The review synthesizes evidence on dogs and cats, linking microbiota alterations to tumorigenesis and discussing diagnostic directions, with relevance to human lymphomas.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-importance-of-intestinal-microbiota-and-dysbiosis-in-the-context-of-the-development-of-intestinal-lymphoma-in-dogs-and-cats/336396/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-importance-of-intestinal-microbiota-and-dysbiosis-in-the-context-of-the-development-of-intestinal-lymphoma-in-dogs-and-cats/336396.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main disease focus of this article?","Question",{"text":113,"@type":114},"The article focuses on intestinal lymphoma in dogs and cats and explains how it arises within the intestinal environment.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does dysbiosis relate to intestinal lymphoma development?",{"text":118,"@type":114},"Dysbiosis disrupts gut microbial balance, triggers inflammation in the intestinal mucosa, and disturbs immune homeostasis, increasing susceptibility to carcinogenic influences.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the article’s goal regarding intestinal microbiota?",{"text":122,"@type":114},"It aims to discuss the optimal composition of the gut microbiome in dogs and cats and potential microbiota alterations during intestinal lesion development, especially intestinal lymphoma.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},336396,1790122195,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","cancers   \nReview  \nThe Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats  \nWioleta Jadwiga Breczko 1, *, Joanna Bubak 2 and Marta Miszczak 3  \nCitation: Breczko, W.J.; Bubak, J.; Miszczak, M. The Importance of Intestinal Microbiota and Dysbiosisin the Context of the Development of Intestinal Lymphoma in Dogs and Cats. Cancers 2024, 16, 2255. [https://](https://)[ ](https://)[doi.org/10.3390/cancers16122255](doi.org/10.3390/cancers16122255)  \nAcademic Editors: Dong Tang and Takeo Fukagawa  \nReceived: 9 May 2024  \nRevised: 5 June 2024  \nAccepted: 13 June 2024  \nPublished: 18 June 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 EZA Student Science Club, The Faculty of Veterinary Medicine in Wroclaw, Wrocław University of Environmental and Life Sciences, 31 Norwida St., 50-375 Wrocław, Poland  \n2 Department of Pathology, Division of Pathomorphology and Veterinary Forensics, The Faculty of Veterinary Medicine in Wrocław, Wrocław University of Environmental and Life Sciences, 31 Norwida St., 50-375 Wrocław, Poland; [joanna.bubak@upwr.edu.pl](joanna.bubak@upwr.edu.pl)  \n3 Department of Epizootiology and Clinic of Birds and Exotic Animals, Division of Infectious Diseases and Veterinary Administration, The Faculty of Veterinary Medicine in Wroclaw, Wrocław University of Environmental and Life Sciences, Grunwaldzki Sq. 45, 50-366 Wrocław, Poland; [marta.miszczak@upwr.edu.pl](marta.miszczak@upwr.edu.pl)  \n* Correspondence: [95837@student.upwr.edu.pl](95837@student.upwr.edu.pl)  \nSimple Summary: Cancer of the lymphatic system is a prevalent disease in dogs and cats, with older pets being the most affected group. However, it is crucial to recognize that animals of any age can develop this condition. Intestinal lymphoma, a type of neoplasm, arises when lymphocytes—white blood cells—become cancerous and proliferate uncontrollably. Recent research suggests that the microbiota, the community of bacteria and other microorganisms in the intestines, may play a role in the development of various diseases, including intestinal lymphoma. A healthy microbiota supports the immune system and prevents harmful cellular changes. In contrast, an imbalance in these microorganisms, potentially caused by poor diet, antibiotic use, or illness, can lead to inflammation and increase the risk of cancer.  \nAbstract: Recent advancements have significantly enhanced our understanding of the crucial role animal microbiomes play in veterinary medicine. Their importance in the complex intestinal environment spans immune modulation, metabolic homeostasis, and the pathogenesis of chronic diseases. Dysbiosis, a microbial imbalance, can lead to a range of diseases affecting both individual organs and the entire organism. Microbial disruption triggers inflammatory responses in the intestinal mucosa and disturbs immune homeostasis, increasing susceptibility to toxins and their metabolites. These dynamics contribute to the development of intestinal lymphoma, necessitating rigorous investigation into the role of microbiota in tumorigenesis. The principles explored in this study extend beyond veterinary medicine to encompass broader human health concerns. There are remarkable parallels between the subtypes of lymphoproliferative disorders in animals and humans, particularly Hodgkin's lymphoma and non-Hodgkin's lymphoma. Understanding the etiology of a cancer of the lymphatic system formation is critical for developing both preventive strategies and therapeutic interventions, with the potential to significantly improve patient outcomes. The aim of this study is to discuss the optimal composition","cbCaiq1VV3vFtPt2","https://ap.wps.com/l/cbCaiq1VV3vFtPt2","pdf",1177362,15,"English","# Introduction\n## Background\n## Objectives of the Article","[{\"question\":\"What is the main disease focus of this article?\",\"answer\":\"The article focuses on intestinal lymphoma in dogs and cats and explains how it arises within the intestinal environment.\"},{\"question\":\"How does dysbiosis relate to intestinal lymphoma development?\",\"answer\":\"Dysbiosis disrupts gut microbial balance, triggers inflammation in the intestinal mucosa, and disturbs immune homeostasis, increasing susceptibility to carcinogenic influences.\"},{\"question\":\"What is the article’s goal regarding intestinal microbiota?\",\"answer\":\"It aims to discuss the optimal composition of the gut microbiome in dogs and cats and potential microbiota alterations during intestinal lesion development, especially intestinal lymphoma.\"}]","The Importance of Intestinal Microbiota and Dysbiosis in the Context of the Development of Intestinal Lymphoma in Dogs and Cats | PDF",1790014864,38]