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The study examines syndromes linked to these diseases to clarify how genetic factors shape disease presentation. The primary aim is genetic investigation to define associations and discover shared genetic determinants across colorectal and gastric cancers. Emphasis is placed on KRAS mutations, nucleic acid polymorphisms, the Wnt signaling pathway, and chemokine ligand roles in tumorigenesis, highlighting the need for biomarkers that support targeted therapies and prevention strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-importance-of-genetic-screening-on-the-syndromes-of-colorectal-cancer-and-gastric-cancer-a-2024-update/331667/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-importance-of-genetic-screening-on-the-syndromes-of-colorectal-cancer-and-gastric-cancer-a-2024-update/331667.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this genetic screening study?","Question",{"text":112,"@type":113},"To investigate genetic associations and identify shared genetic determinants across colorectal and gastric cancer syndromes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biological pathways and genetic elements are highlighted in the research?",{"text":117,"@type":113},"KRAS gene mutations and nucleic acid polymorphisms, the Wnt signaling pathway, and chemokine ligand involvement in tumorigenesis.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are biomarkers and ongoing research emphasized?",{"text":121,"@type":113},"Because suitable biomarkers are needed to better identify and understand the genetic links and to support targeted therapies and preventive strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331667,1791543814,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","Review  \nThe Importance of Genetic Screening on the Syndromes of Colorectal Cancer and Gastric Cancer: A 2024 Update  \nIulia Lupan 1, Ciprian Silaghi 2, Claudia Stroe 3, Adriana Muntean 3, Diana Deleanu 3, Vasile Bintintan 4 and Gabriel Samasca 3, *  \nCitation: Lupan, I.; Silaghi, C.; Stroe, C.; Muntean, A.; Deleanu, D.; Bintintan, V.; Samasca, G. The Importance of Genetic Screening on the Syndromes of Colorectal Cancer and Gastric Cancer: A 2024 Update. Biomedicines 2024, 12, 2655 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biomedicines12122655  \nAcademic Editor: Christos K. Kontos  \nReceived: 19 September 2024  \nRevised: 15 November 2024  \nAccepted: 19 November 2024  \nPublished: 21 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Molecular Biology, Babes-Bolyai University, 400084 Cluj-Napoca, Romania; [iulia.lupan@ubbcluj.ro](iulia.lupan@ubbcluj.ro)  \n2 Department of Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy,  \n400006 Cluj-Napoca, Romania; [silaghi.ciprian@umfcluj.ro](silaghi.ciprian@umfcluj.ro)  \n3 Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy,  \n400006 Cluj-Napoca, Romania; [claustroe@gmail.com](claustroe@gmail.com) (C.S.); [adriana.muntean@umfcluj.ro](adriana.muntean@umfcluj.ro) (A.M.); [deleanu@umfcluj.ro](deleanu@umfcluj.ro) (D.D.)  \n4 Department of Surgery 1, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania; [vasile.bintintan@umfcluj.ro](vasile.bintintan@umfcluj.ro)  \n* Correspondence: [gabriel.samasca@umfcluj.ro](gabriel.samasca@umfcluj.ro)  \nAbstract: Gastrointestinal cancers (GIC), encompassing colonic, rectal, and gastric malignancies, rank among the most prevalent cancer types globally, contributing significantly to cancer-related mortality. In the scientific literature, various syndromes associated with colorectal and gastric cancers have been elucidated, highlighting the intricate interplay between genetic factors and disease manifestation. The primary objective of this study was to conduct a genetic exploration aimed at elucidating these associations and identifying shared genetic determinants across these cancer types. Notably, considerable research has focused on the KRAS gene mutations, polymorphisms in nucleic acids, the Wnt signaling pathway, and the role of chemokine ligands in tumorigenesis. While investigations into natural plant extracts as potential therapeutic agents are still in their nascent stages, they represent a promising avenue for future research. Ongoing studies are essential to uncover suitable biomarkers that could facilitate the identification and understanding of the genetic links between these GIC. This exploration not only seeks to enhance our comprehension of the underlying genetic architecture but also aims to inform the development of targeted therapies and preventive strategies.  \nKeywords: genetics; colorectal cancer; gastric cancer  \n1. Introduction  \nGastrointestinal (GI) malignancies are characterized by significant heterogeneity at multiple levels, which poses challenges for diagnosis and treatment. Recent research has delved into tumor heterogeneity through molecular profiling techniques, including transcriptomic, proteomic, genetic, and epigenetic classifications. Among these, transcriptomic subtyping has emerged as a particularly advantageous approach, as it synthesizes information about the tumor microenvironment (TME), intrinsic cancer cell properties, and both genetic and epigenetic factors. This method has garnered attention due to its ability to reveal common biological characteristics across various GI tumo","cbCaitYYmS4JYBtG","https://ap.wps.com/l/cbCaitYYmS4JYBtG","pdf",719546,26,"English","# Introduction\n## Genomic and molecular profiling in GI malignancies\n## Epidemiology and prognosis context\n## Genetic syndromes and shared determinants across CRC and GC","[{\"question\":\"What is the main objective of this genetic screening study?\",\"answer\":\"To investigate genetic associations and identify shared genetic determinants across colorectal and gastric cancer syndromes.\"},{\"question\":\"Which biological pathways and genetic elements are highlighted in the research?\",\"answer\":\"KRAS gene mutations and nucleic acid polymorphisms, the Wnt signaling pathway, and chemokine ligand involvement in tumorigenesis.\"},{\"question\":\"Why are biomarkers and ongoing research emphasized?\",\"answer\":\"Because suitable biomarkers are needed to better identify and understand the genetic links and to support targeted therapies and preventive strategies.\"}]","The Importance of Genetic Screening on the Syndromes of Colorectal Cancer and Gastric Cancer: A 2024 Update | PDF",1789994526,66]