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In head and neck cancers, immune microenvironment features and immune infiltration are central to cancer pathogenesis. This study analyzed the distribution of tumor-infiltrating lymphocyte (TIL) subgroups within the immune microenvironment and their links to histopathology and prognosis in 50 laryngeal squamous cell carcinoma patients treated by laryngectomy.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-impact-of-the-tumor-immune-microenvironment-and-tumor-infiltrating-lymphocyte-subgroups-on-laryngeal-cancer-prognosis-research-article/332260/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-impact-of-the-tumor-immune-microenvironment-and-tumor-infiltrating-lymphocyte-subgroups-on-laryngeal-cancer-prognosis-research-article/332260.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To determine how tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment relate to tumor histopathological characteristics and prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were TIL subgroups measured in this research?",{"text":117,"@type":113},"Pathology specimens from 50 laryngeal cancer patients were evaluated by immunohistochemistry for CD3, CD20, CD8, CD4, CD25, and FoxP3 markers.",{"name":119,"@type":110,"acceptedAnswer":120},"Which TIL marker findings were associated with better survival outcomes?",{"text":121,"@type":113},"High infiltration of CD3, CD20, and CD4 showed positive associations with disease-specific survival, disease-free survival, and recurrence-free survival, and overall survival was also positively affected by high CD3 and CD4.",{"name":123,"@type":110,"acceptedAnswer":124},"Were CD8, FoxP3, or CD25 linked to survival parameters?",{"text":125,"@type":113},"No significant relationships were observed between CD8, FoxP3, or CD25 expression and any survival parameters.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332260,1790710353,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Original Research Article SCIENCE PROGRESS  \nThe impact of the tumor immune microenvironment and tumor-infiltrating lymphocyte subgroups on laryngeal cancer prognosis  \nF ırat Tevetŏglu 1,2 , Nil Çomunŏglu3 and Haydar Murat Yener2  \n1 Otorhinolaryngology Department, Marmara University Pendik Training and Research Hospital, Istanbul, Türkiye  \n2Otorhinolaryngology Department, Istanbul University – Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Türkiye  \n3Pathology Department, Istanbul University – Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Türkiye  \nScience Progress 2024, Vol. 107(3) 1–18 © The Author(s) 2024 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/00368504241266087](DOI: 10.1177/00368504241266087)[ ](DOI: 10.1177/00368504241266087)[journals.sagepub.com/home/sci](journals.sagepub.com/home/sci)  \nAbstract  \nThe absence of improvement in survival rates across various cancers, including laryngeal cancer, has led to an increasing interest in understanding the immune response to cancer. In head and neck cancers, immune modulatory mechanisms such as immune microenvironment and immune infiltration are important in cancer pathogenesis. This study aims to explore the distribution of tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment and evaluate their impact on tumor histopathological characteristics and prognosis. The study included 50 patients who underwent laryngectomy for laryngeal squamous cell carcinoma, in Istanbul University - Cerrahpaşa, Faculty of Medicine Department of Otorhinolaryngology, between January 2016 and January 2018. Pathology specimens were evaluated using immunohistochemistry to assess the expressions of the CD3, CD20, CD8, CD4, CD25, and FoxP3 markers, identifying subgroups of TILs. The investigation aimed to uncover how these subgroups influence tumor histopathological features and survival outcomes. The high infiltration of CD3, CD20, and CD4 had a positive impact on disease-specific survival, disease-free survival, and recurrence-free survival. In addition, overall survival was positively affected by high CD3 and CD4 infiltrations. However, no significant relationship was observed between the expressions of CD8, FoxP3, and CD25 and any of the survival parameters. The infiltration of CD3, CD20, and CD4 positive cells indicative of a robust antitumoral immune response—emerged as favorable prognostic  \nCorresponding author:  \nFırat Tevetŏglu, Otorhinolaryngology Department, Marmara University Pendik Training and Research Hospital, Fevzi Çakmak Mh. Muhsin Yazıcıŏglu Cd. No: 10, 34899, Pendik, Istanbul, Türkiye.  \nEmail: fi[rattevetoglu@gmail.com](rattevetoglu@gmail.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative  \nCommons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nfactors in laryngeal cancer. These findings suggest that enhancing the infiltration of CD3, CD20, and CD4 lymphocytes could be a therapeutic strategy worth exploring in clinical trials.  \nKeywords  \nLaryngeal cancer, tumor immune microenvironment, tumor-infiltrating lymphocytes, regulatory t lymphocytes  \nIntroduction  \nLaryngeal cancer is one of the most prevalent head and neck cancers (HNCs) with an overall 5-year survival rate of 67% .1 Despite diagnostic and therapeutic advances over the past half-century, the mortality rates for many malignancies, including laryngeal cancer, have not significantly decreased. This has prompted interest in understanding the immune mech","cbCairC63MJj210o","https://ap.wps.com/l/cbCairC63MJj210o","pdf",1923939,18,"English","# Abstract\n# Introduction\n## Tumor microenvironment and immune escape\n## Tumor-infiltrating lymphocytes and key TIL subgroups","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To determine how tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment relate to tumor histopathological characteristics and prognosis.\"},{\"question\":\"How were TIL subgroups measured in this research?\",\"answer\":\"Pathology specimens from 50 laryngeal cancer patients were evaluated by immunohistochemistry for CD3, CD20, CD8, CD4, CD25, and FoxP3 markers.\"},{\"question\":\"Which TIL marker findings were associated with better survival outcomes?\",\"answer\":\"High infiltration of CD3, CD20, and CD4 showed positive associations with disease-specific survival, disease-free survival, and recurrence-free survival, and overall survival was also positively affected by high CD3 and CD4.\"},{\"question\":\"Were CD8, FoxP3, or CD25 linked to survival parameters?\",\"answer\":\"No significant relationships were observed between CD8, FoxP3, or CD25 expression and any survival parameters.\"}]","The impact of the tumor immune microenvironment and tumor-infiltrating lymphocyte subgroups on laryngeal cancer prognosis - Research Article | PDF",1789997583,45]