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Biological significance of repertoire diversity in older adults remains unclear. Using MiXCR with bulk RNAseq from 3,758 Health and Retirement Study participants, the study estimates receptor clone numbers and diversity, relates them to demographic and risk factors, and links them to 4-year mortality using adjusted logistic regression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-impact-of-t-cell-repertoire-on-mortality-findings-from-the-health-and-retirement-study-research-report/427836/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-impact-of-t-cell-repertoire-on-mortality-findings-from-the-health-and-retirement-study-research-report/427836.png","ImageObject",300,407,{"name":92,"@type":93},"Jordan Avery","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-17","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were T/B cell repertoires measured in the study?","Question",{"text":112,"@type":113},"The study used MiXCR on bulk RNAseq data to estimate T/B receptor chain numbers (total clones) and chain diversity (unique clones).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors were analyzed for associations with the T/B cell repertoire?",{"text":117,"@type":113},"Associations were evaluated with demographic variables (age, sex, race) and other factors including smoking and CMV seroprevalence using type-II ANOVA and adjusted models.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the relationship between TCR repertoire metrics and 4-year mortality?",{"text":121,"@type":113},"Higher numbers of TCR chains and higher TCR clonal diversity were significantly associated with reduced mortality in logistic regression models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427836,1791557305,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},1099523882367,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Innovation in Aging, 2025, Vol. 9, No. S2 877  \nAbstract citation ID: igaf122.2968  \nTHE IMPACT OF T CELL REPERTOIRE ON MORTALITY: FINDINGS FROM THE HEALTH AND RETIREMENT STUDY  \nZach Flaten1, Ryan Martinez1, Sithara Vivek1, Shijia Zhu1, Jessica Faul2, Eileen Crimmins3, Gokul Seshadri1, and  \nBharat Thyagarajan1, 1. University of Minnesota, Minneapolis, Minnesota, United States, 2. University of Michigan, Ann Arbor, Michigan, United States, 3. University of Southern California, Los Angeles, California, United States  \n878 Innovation in Aging, 2025, Vol. 9, No. S2  \nThe T and B cell repertoire is the sum of all the T-cell receptors (TCRs) and B cell receptors (BCRs) in an individual and is an indicator of the cumulative exposure of immune challenges over the life course. The biological importance of T/B cell repertoire diversity in a general population of older adults remains unclear.  \nIn the Health and Retirement Study, we used MiXCR on bulk RNAseq data to estimate T/B receptor chain numbers (total clones) and T/B receptor chain diversity (number of unique clones) for 3,758 participants. We evaluated the demographic (age, sex, race) and other factors (smoking, CMV seroprevalence) associated with T/B cell repertoire using type-IIANOVA. We used unconditional logistic regression models to evaluate the association between T/B cell repertoire and 4-year mortality. All the models were adjusted for age, sex, race, CMV seropositivity, smoking status, total number of sequencing reads, and total T cell/ B cell counts. The number and diversity of T and B cell receptor chains identified were higher among African Americans as compared to other racial groups. The number and diversity ofTCR chains were more common in women, elevated in CMVseropositive individuals. TCR chains were more common in never smokers, but the TCR diversity was higher in current smokers. Moreover, higher numbers of TCR chains (OR:  \nTRA=0.74;p=0.0008, TRB=0.76;p=0.0018) and TCR clonal diversity (OR: TRA=0.66; p\u003C0.0001, TRB=0.7; p\u003C0.0001) were significantly associated with reduced mortality. Further research is needed to understand mechanisms by which TCR impact population health.","cbCaiu9d10m7YHIH","https://ap.wps.com/l/cbCaiu9d10m7YHIH","pdf",68742,"English","# Abstract\n## Study methods and analysis\n## Key findings and associations\n## Implications and future research","[{\"question\":\"How were T/B cell repertoires measured in the study?\",\"answer\":\"The study used MiXCR on bulk RNAseq data to estimate T/B receptor chain numbers (total clones) and chain diversity (unique clones).\"},{\"question\":\"Which factors were analyzed for associations with the T/B cell repertoire?\",\"answer\":\"Associations were evaluated with demographic variables (age, sex, race) and other factors including smoking and CMV seroprevalence using type-II ANOVA and adjusted models.\"},{\"question\":\"What was the relationship between TCR repertoire metrics and 4-year mortality?\",\"answer\":\"Higher numbers of TCR chains and higher TCR clonal diversity were significantly associated with reduced mortality in logistic regression models.\"}]","THE IMPACT OF T CELL REPERTOIRE ON MORTALITY: FINDINGS FROM THE HEALTH AND RETIREMENT STUDY - Research report | PDF",1790644925]