[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336150-105":59,"doc-detail-336150-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-impact-of-pre-biopsy-mri-and-additional-testing-on-prostate-cancer-screening-outcomes-a-rapid-review","The impact of pre-biopsy MRI and additional testing on prostate cancer screening outcomes: A rapid review","","Objective: Examine latest evidence on how pre-biopsy MRI, alongside prostate-specific antigen (PSA) testing, influences prostate cancer screening outcomes and quality of life. Methods: Conducted a literature search in PubMed and Cochrane CENTRAL (Jan 2005–25 Jan 2023), selecting randomized trials and cohort studies via independent review. Results: Seven trials were included; MRI-based strategies increased clinically significant cancer detection and reduced clinically insignificant cancer detection compared with standard biopsy. Conclusion: A combined approach centered on pre-biopsy MRI may reduce unnecessary biopsies and overdiagnosis versus PSA testing and standard biopsy alone; long-term mortality impact remains unassessed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-impact-of-pre-biopsy-mri-and-additional-testing-on-prostate-cancer-screening-outcomes-a-rapid-review/336150/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-impact-of-pre-biopsy-mri-and-additional-testing-on-prostate-cancer-screening-outcomes-a-rapid-review/336150.png","ImageObject",300,407,{"name":92,"@type":93},"Ava Thompson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this rapid review?","Question",{"text":112,"@type":113},"To assess the latest evidence on how pre-biopsy MRI and additional testing, alongside PSA testing, affect health outcomes and quality of life in prostate cancer screening pathways.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which study types and data sources were used in the review?",{"text":117,"@type":113},"The review searched PubMed and Cochrane Central Register of Controlled Trials (CENTRAL), then included randomized controlled trials and cohort studies meeting predefined inclusion criteria.",{"name":119,"@type":110,"acceptedAnswer":120},"How did MRI-based interventions affect cancer detection and biopsies compared with standard biopsy?",{"text":121,"@type":113},"Across most included studies, MRI-based approaches increased detection of clinically significant cancers and reduced detection of clinically insignificant cancers. MRI also helped some men avoid biopsy in several studies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336150,1790732192,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","DOI: 10.1002/bco2.321  \nREVIEW  \nThe impact of pre-biopsy MRI and additional testing on prostate cancer screening outcomes: A rapid review  \nAbel Tesfai  | Natalia Norori  | Thomas A. Harding  | Yui Hang Wong  | Matthew David Hobbs  \nProstate Cancer UK, London, UK  \nCorrespondence  \nAbel Tesfai and Natalia Norori, Prostate Cancer UK, London, UK.  \nEmail: [abel.tesfai@prostatecanceruk.org](abel.tesfai@prostatecanceruk.org); [natalia.norori@prostatecanceruk.org](natalia.norori@prostatecanceruk.org)  \nFunding information Prostate Cancer UK  \nAbstract  \nObjective: This work aims to examine the latest evidence on the impact of prebiopsy MRI, in addition to prostate-specific antigen (PSA) testing, on health outcomesand quality of life.  \nMethods: We conducted a literature search including PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) databases, with a limited scan of (i) guidelines and (ii) references from trial reports, from January 2005 to 25th January 2023. Two independent reviewers selected randomised controlled trials (RCT) and cohort studies which met our inclusion criteria.  \nResults: One hundred thirty-seven articles were identified, and seven trial articles were selected. Trial interventions were as follows: (i) PSA blood test, (ii) additional tests such as pre-biopsy multiparametric magnetic resonance imaging (mpMRI) and Biparametric MRI (bpMRI), and (iii) MRI targeted biopsy and standard biopsy. Compared with standard biopsy, MRI-based interventions led to increased detection of clinically significant cancers in three studies and decreased detection of clinically insignificant cancer (Gleason grade 3 + 3) in four studies. However, PROstate Magnetic resonance Imaging Study (PROMIS) and Stockholm3 with MRI (STHLM3-MRI) studies reported different trends depending on the scenario studied in PROMIS (MRI triage and MRI directed biopsy vs. MRI triage and standard biopsy) and thresholds used in STHLM3-MRI (≥0􀀁11 and ≥0􀀁15) . MRI also helped 8%–49% of men avoid biopsy, in six out of seven studies, but not in STHLM3-MRI at ≥0 .11. Interestingly, the proportion of men who experienced sepsis and UTI was low across studies. Conclusion: This review found that a combination of approaches, centred on the use of pre-biopsy MRI, may improve the detection of clinically significant cancers and reduce (i) the diagnosis of clinically insignificant cancers and (ii) unnecessary biopsies, compared with PSA testing and standard biopsy alone. However, the impact of such  \nReview question: Have the benefits and harms of PSA-based prostate cancer screening changed since the introduction of pre-biopsy MRI and additional testing into the prostate cancer pathway?  \nProtocol registration link (Open Science Framework): [https://osf.io/8my6f](https://osf.io/8my6f).  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.  \ninterventions on longer term outcomes such as prostate cancer-specific mortality has not yet been assessed.  \nKEYW OR DS  \nbpMRI, mpMRI, overdiagnosis, pre-biopsy, PSA  \n1 | INTRODUCTION  \nThe traditional prostate cancer diagnostic pathway used the prostatespecific antigen (PSA) test and transrectal ultrasonography (TRUS) -guided 10-to 12-core systematic biopsy. However, the use of PSA to determine diagnostic pathway progression has been linked to overdiagnosis, with one study reporting that 70%–80% of patients with PSA levels >4 ng/mL did not in fact have cancer.1 It is also unclear how well PSA levels predict outcomes for low and intermediate-risk cancers.2 Importantly, men who progress through the diagnostic pathway may suffer from physical and psychological issues such as anxiety. More specifically, prostate biopsies have been associated with bleeding, urinary","cbCaicManUcFWO7U","https://ap.wps.com/l/cbCaicManUcFWO7U","pdf",832764,13,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the main objective of this rapid review?\",\"answer\":\"To assess the latest evidence on how pre-biopsy MRI and additional testing, alongside PSA testing, affect health outcomes and quality of life in prostate cancer screening pathways.\"},{\"question\":\"Which study types and data sources were used in the review?\",\"answer\":\"The review searched PubMed and Cochrane Central Register of Controlled Trials (CENTRAL), then included randomized controlled trials and cohort studies meeting predefined inclusion criteria.\"},{\"question\":\"How did MRI-based interventions affect cancer detection and biopsies compared with standard biopsy?\",\"answer\":\"Across most included studies, MRI-based approaches increased detection of clinically significant cancers and reduced detection of clinically insignificant cancers. MRI also helped some men avoid biopsy in several studies.\"}]","The impact of pre-biopsy MRI and additional testing on prostate cancer screening outcomes: A rapid review | PDF",1790013832,33]