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It also reviews EMT roles in therapy resistance, recurrence, and metastatic progression, and discusses treatment strategies targeting intracellular signaling networks and EMT-driven metabolic changes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-impact-of-epithelial-mesenchymal-transition-emt-induced-by-metabolic-processes-and-intracellular-signaling-pathways-on-chemo-resistance-metastasis-and-recurrence-in-solid-tumors/332822/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-impact-of-epithelial-mesenchymal-transition-emt-induced-by-metabolic-processes-and-intracellular-signaling-pathways-on-chemo-resistance-metastasis-and-recurrence-in-solid-tumors/332822.png","ImageObject",300,407,{"name":42,"@type":43},"Evangeline","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is epithelial-mesenchymal transition (EMT) and why is it important in solid tumors?","Question",{"text":63,"@type":64},"EMT is a phenotypic change where epithelial cells acquire mesenchymal traits. 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Cell Communication and Signaling (2024) 22:575  \n[https://doi.org/10.1186/s12964-024-01957-4](https://doi.org/10.1186/s12964-024-01957-4)  \nCell Communication and Signaling  \nREVIEW Open Access  \nThe impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors  \nMahsa Liaghat 1,2†, Saeid Ferdousmakan3†, Seyedeh Haniyeh Mortazavi4, Sheida Yahyazadeh5, Asrin Irani6, Sara Banihashemi7, Fatemeh Sadat Seyedi Asl8, Abdullatif Akbari2,9, Farnoosh Farzam 10, Fatemeh Aziziyan2,10, Maryam Bakhtiyari2,11, Mohammad Javad Arghavani 12, Hamidreza Zal poor2,9* and Mohsen Nabi-Afjadi 10*  \nAbstract  \nThe intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors. This review article focuses on the signals that promote EMT and metabolism, the intracellular signaling pathways leading to EMT, and the network of interactions between EMT and cancer cell metabolism. Furthermore, the functions of EMT in treatment resistance, recurrence, and metastasis of solid cancers are covered. Lastly, treatment approaches that focus on intracellular signaling networks and metabolic alterations brought on by EMT will be discussed.  \nKeywords EMT, Solid tumors, Metabolic profile, Chemotherapy resistance, Metastasis, Tumor recurrence  \n†Mahsa Liyaghat and Saeid Ferdousmakan contributed equally to this work.  \n*Correspondence:  \nHamidreza Zal poor [hamidreza.zl pr1998@gmail.com](hamidreza.zl pr1998@gmail.com)[ ](hamidreza.zl pr1998@gmail.com)Mohsen Nabi-Afjadi [mohsen.nabiafjadi@modares.ac.ir](mohsen.nabiafjadi@modares.ac.ir)  \n1Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran  \n2Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran 3Department of Pharmacy Practice, Nargund College of Pharmacy, Bangalore 560085, India  \n4Neurosurgery Department of Shiraz University of Medical Sciences, Shiraz, Iran  \n5Department of Immunology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran  \n6Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran  \n7Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, UK  \n8Medical School, Tehran University of Medical Sciences, Tehran, Iran 9Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran  \n10Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran  \n11Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran  \n12Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indic","cbCailevGmhW02me","https://ap.wps.com/l/cbCailevGmhW02me","pdf",2232808,24,"English","# Introduction\n## EMT and partial EMT in solid tumors\n## Microenvironmental signaling that induces EMT\n## EMT metabolism and intracellular signaling pathways\n## EMT functions in chemo-resistance, metastasis, and recurrence\n## Therapeutic approaches targeting metabolic and signaling networks","[{\"question\":\"What is epithelial-mesenchymal transition (EMT) and why is it important in solid tumors?\",\"answer\":\"EMT is a phenotypic change where epithelial cells acquire mesenchymal traits. In solid tumors, EMT promotes invasion, metastasis, drug resistance, and recurrence by reshaping cell structure, metabolism, and gene expression.\"},{\"question\":\"How do metabolic processes and intracellular signaling pathways relate to EMT?\",\"answer\":\"The review highlights that signals promoting EMT and metabolism are connected through intracellular signaling pathways. These pathways coordinate the network of interactions between EMT and cancer cell metabolic programs.\"},{\"question\":\"What roles does EMT play in chemo-resistance, metastasis, and tumor recurrence?\",\"answer\":\"EMT contributes to treatment resistance, metastatic spread, and recurrence. It generates cellular states, including partial EMT, that support altered circulation, colonization of new sites, and metastatic potential.\"}]","The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors | PDF",1789999622]