[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-457985-105":59,"doc-detail-457985-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-impact-of-early-rehabilitation-on-patients-with-acute-cerebral-infarction-and-chronic-kidney-disease-a-retrospective-cohort-study","The Impact of Early Rehabilitation on Patients With Acute Cerebral Infarction and Chronic Kidney Disease - A Retrospective Cohort Study","","Chronic kidney disease (CKD) coexisting with cerebral infarction (CI) elevates the risk of adverse outcomes, but the influence of CKD presence and severity on early rehabilitation effectiveness is unclear. This retrospective cohort study analyzed 764 CI patients (2014–2021), selecting 402 first-CI patients undergoing inpatient rehabilitation and stratifying them by eGFR into mild (≥45 mL/min/1.73m2) versus severe (\u003C45 mL/min/1.73m2) groups. Propensity score matching yielded 48 patients per group. Outcomes at discharge—modified Rankin Scale (mRS), Barthel Index (BI), and length of stay—showed no significant differences by CKD status or severity, supporting early rehabilitation’s benefits regardless of CKD.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-impact-of-early-rehabilitation-on-patients-with-acute-cerebral-infarction-and-chronic-kidney-disease-a-retrospective-cohort-study/457985/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-impact-of-early-rehabilitation-on-patients-with-acute-cerebral-infarction-and-chronic-kidney-disease-a-retrospective-cohort-study/457985.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about CKD and early rehabilitation?","Question",{"text":112,"@type":113},"It examines whether the presence or severity of chronic kidney disease (CKD) affects the effectiveness of early rehabilitation in patients with acute cerebral infarction (CI).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients grouped for analysis?",{"text":117,"@type":113},"Patients were categorized by estimated glomerular filtration rate (eGFR) into a mild group (≥45 mL/min/1.73m2) and a severe group (\u003C45 mL/min/1.73m2). Propensity score matching was then used to balance background factors.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the primary outcomes and did they differ between CKD groups?",{"text":121,"@type":113},"The primary outcomes were modified Rankin Scale (mRS) and Barthel Index (BI) scores at discharge, plus hospital stay duration. After matching, no significant differences were found between mild and severe CKD groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},457985,1791097738,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review began 11/05/2025  \nReview ended 11/30/2025  \nPublished 12/08/2025  \n© Copyright 2025  \nNomoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98765  \nOpen Access Original Article  \nThe Impact of Early Rehabilitation on Patients With Acute Cerebral Infarction and Chronic Kidney Disease: A Retrospective Cohort Study  \nMasahiro Nomoto 1, Kazuhiro Miyata 2, Yutaka Kohno 3  \n1. Department of Rehabilitation, Nerimahikarigaoka Hospital, Nerima, JPN 2. Department of Physical Therapy, Ibaraki Prefectural University of Health Sciences, Ami-machi, JPN 3. Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ami-machi, JPN  \nCorresponding author: Kazuhiro Miyata, [miyatak@ipu.ac.jp](miyatak@ipu.ac.jp)  \nAbstract  \nBackground and objective  \nPatients with cerebral infarction (CI) who also have chronic kidney disease (CKD) are at an increased risk of adverse outcomes. However, it remains uncertain whether the presence or severity of CKD influences the effectiveness of early rehabilitation. This study aimed to investigate the impact of early rehabilitation, taking into account both the presence and severity of CKD.  \nMethods  \nThis study initially included 764 patients diagnosed with CI between April 2014 and March 2021 at Nerimahikarigaoka Hospital. From this cohort, 402 patients experiencing their first CI who underwent inpatient rehabilitation were selected as the study population. Patients were categorized into two groups according to estimated glomerular filtration rate (eGFR) using the modified formula from the 2018 Evidencebased Clinical Practice Guidelines for Chronic Kidney Disease, which applies to Japanese patients: the mild group (≥45 mL/min/1 .73m2) and the severe group (\u003C45 mL/min/1 .73m2) . Statistical analysis involved 1 : 1 propensity score matching based on background factors, and standardized mean differences (SMD) were calculated. After matching, 48 patients remained in each group, due to an imbalance in baseline renal function distribution. Variables were selected based on the definition of early mobilization and factors influencing renal function decline, including age, sex, stroke type, number of stroke risk factors, and days from hospital admission to initiation of wheelchair use, standing, and gait training. Both groups were compared in terms of the primary outcomes, namely the modified Rankin Scale (mRS) and Barthel Index (BI) scores at discharge, as well as hospital stay duration.  \nResults  \nThe SMDs for background factors after propensity score matching were as follows: age (0 .013), time to initiation of wheelchair use (0 . 16), time to start of standing rehabilitation (0 .071), mRS at admission (0 .068), and BI at admission (\u003C0 .001) . No significant differences were observed between the two groups in mRS at discharge (p = 0 .485), BI at discharge (p = 0 .431), or length of hospital stay (p = 0 .226) .  \nConclusions  \nOur study revealed that early rehabilitation in CI patients consistently improves physical function, activities of daily living at discharge, and length of hospital stay, irrespective of the presence or severity of CKD. These findings highlight the clinical significance of early mobilization in CI patients with CKD.  \nCategories: Neurology, Physical Medicine & Rehabilitation, Nephrology  \nKeywords: barthel index, chronic kidney disease, early mobilization, modified rankin scale, propensity score  \nmatching, rehabilitation  \nIntroduction  \nPatients with cerebral infarction (CI) complicated by chronic kidney disease (CKD) have been reported to exhibit higher post-onset mortality and increased risk of poor outcomes [1-3]. CKD complications are associated with blood pressure fluctuations due to impaired cerebral autoregulation and autonomic ","cbCaigAz9LEssWWj","https://ap.wps.com/l/cbCaigAz9LEssWWj","pdf",547991,"English","# Abstract\n## Background and objective\n## Methods\n## Results\n## Conclusions\n# Introduction\n# How to cite this article","[{\"question\":\"What question does the study address about CKD and early rehabilitation?\",\"answer\":\"It examines whether the presence or severity of chronic kidney disease (CKD) affects the effectiveness of early rehabilitation in patients with acute cerebral infarction (CI).\"},{\"question\":\"How were patients grouped for analysis?\",\"answer\":\"Patients were categorized by estimated glomerular filtration rate (eGFR) into a mild group (≥45 mL/min/1.73m2) and a severe group (\\u003c45 mL/min/1.73m2). Propensity score matching was then used to balance background factors.\"},{\"question\":\"What were the primary outcomes and did they differ between CKD groups?\",\"answer\":\"The primary outcomes were modified Rankin Scale (mRS) and Barthel Index (BI) scores at discharge, plus hospital stay duration. After matching, no significant differences were found between mild and severe CKD groups.\"}]","The Impact of Early Rehabilitation on Patients With Acute Cerebral Infarction and Chronic Kidney Disease - A Retrospective Cohort Study | PDF",1790751174,23]