[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-341147-105":59,"doc-detail-341147-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-impact-of-cancer-stem-cells-in-colorectal-cancer-review","The Impact of Cancer Stem Cells in Colorectal Cancer - Review","","Despite ongoing research, colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Improvements in medical treatments have increased survival, yet metastatic CRC management requires balancing treatment benefits against adverse effects, toxicity, disease progression, and drug resistance while protecting patients’ quality of life. Growing evidence supports the cancer stem cell (CSC) concept: colorectal cancer stem cells drive tumor initiation, metastasis, and therapy resistance. This review summarizes current research on CSCs in CRC and their resistance mechanisms.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-impact-of-cancer-stem-cells-in-colorectal-cancer-review/341147/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-impact-of-cancer-stem-cells-in-colorectal-cancer-review/341147.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is metastatic colorectal cancer difficult to manage?","Question",{"text":113,"@type":114},"Metastatic CRC requires a tradeoff between potential treatment benefits and adverse effects, considering progression, toxicity, drug resistance, and the patient’s quality of life.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What role do colorectal cancer stem cells (CCSCs) play in CRC?",{"text":118,"@type":114},"CCSCs are important for tumor initiation, metastasis, and therapy resistance, making them potential targets for treatment.",{"name":120,"@type":111,"acceptedAnswer":121},"What does the paper aim to provide about cancer stem cells in colorectal cancer?",{"text":122,"@type":114},"It provides an overview of current research on understanding CSCs in colorectal cancer, with emphasis on drug resistance mechanisms.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},341147,1790097394,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nThe Impact of Cancer Stem Cells in Colorectal Cancer  \nPetru Radu 1, Mihai Zurzu 1, *, Anca Tigora 1, Vlad Paic 1, Mircea Bratucu 1, Dragos Garofil 1, Valeriu Surlin 2, Alexandru Claudiu Munteanu 2, Ionut Simion Coman 1,3, Florian Popa 1, Victor Strambu 1 and Sandu Ramboiu 2  \nCitation: Radu, P.; Zurzu, M.; Tigora, A.; Paic, V.; Bratucu, M.; Garofil, D.; Surlin, V.; Munteanu, A.C.; Coman, I.S.; Popa, F.; et al. The Impact of Cancer Stem Cells in Colorectal Cancer. Int. J. Mol. Sci. 2024, 25, 4140 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25084140  \nAcademic Editor: Tomoyasu Sugiyama  \nReceived: 10 March 2024  \nRevised: 5 April 2024  \nAccepted: 8 April 2024  \nPublished: 9 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Tenth Department of Surgery, University of Medicine and Pharmacy “Carol Davila” Bucharest,  \n050474 Bucharest, Romania; [petru.radu@umfcd.ro](petru.radu@umfcd.ro) (P.R.); [anca.tigora@drd.umfcd.ro](anca.tigora@drd.umfcd.ro) (A.T.); [vlad.paic@drd.umfcd.ro](vlad.paic@drd.umfcd.ro) (V.P.); [mircea.bratucu@umfcd.ro](mircea.bratucu@umfcd.ro) (M.B.); dragos.garofil@umfcd.ro (D.G.); ionut.coman@umfcd.ro (I.S.C.); florian.popa@spcaroldavila.ro (F.P.); victor.strambu@umfcd.ro (V.S.)  \n2 Sixth Department of Surgery, University of Medicine and Pharmacy of Craiova, Craiova Emergency Clinical 7 Hospital, 200642 Craiova, Romania; [valeriu.surlin@umfcv.ro](valeriu.surlin@umfcv.ro) (V.S.); [alexandru.munteanu@umfcv.ro](alexandru.munteanu@umfcv.ro) (A.C.M.); [sandu.ramboiu@umfcv.ro](sandu.ramboiu@umfcv.ro) (S.R.)  \n3 General Surgery Department,“Bagdasar-Arseni” Clinical Emergency Hospital, 12 Berceni Road,  \n041915 Bucharest, Romania  \n* [Correspondence: mihai.zurzu@drd.umfcd.ro](Correspondence: mihai.zurzu@drd.umfcd.ro)  \nAbstract: Despite incessant research, colorectal cancer (CRC) is still one of the most common causes of fatality in both men and women worldwide. Over time, advancements in medical treatments have notably enhanced the survival rates of patients with colorectal cancer. Managing metastatic CRC involves a complex tradeoff between the potential benefits and adverse effects of treatment, considering factors like disease progression, treatment toxicity, drug resistance, and the overall impact on the patient’s quality of life. An increasing body of evidence highlights the significance of the cancer stem cell (CSC) concept, proposing that CSCs occupy a central role in triggering cancer. CSCs have been a focal point of extensive research in a variety of cancer types, including CRC. Colorectal cancer stem cells (CCSCs) play a crucial role in tumor initiation, metastasis, and therapy resistance, making them potential treatment targets. Various methods exist for isolating CCSCs, and understanding the mechanisms of drug resistance associated with them is crucial. This paper offers an overview of the current body of research pertaining to the comprehension of CSCs in colorectal cancer.  \nKeywords: colorectal cancer; cancer stem cells; colorectal cancer stem cells; signaling pathways  \n1. Introduction  \nCRC ranks as the third leading cause of cancer-related fatalities on a global scale [1] . Rather than being a singular consistent ailment, accumulating evidence suggests that CRC represents a spectrum of diseases characterized by diverse molecular profiles [2–4] . This inherent diversity presents formidable challenges in the pursuit of precision medicine via molecular-targeted therapies. Recent advancements in comprehensive molecular profiling and pathology examinations of CRC have substantially enriched our understanding of the genomic and epigenomic ","cbCaiuhCfvIfqLit","https://ap.wps.com/l/cbCaiuhCfvIfqLit","pdf",1616422,27,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"Why is metastatic colorectal cancer difficult to manage?\",\"answer\":\"Metastatic CRC requires a tradeoff between potential treatment benefits and adverse effects, considering progression, toxicity, drug resistance, and the patient’s quality of life.\"},{\"question\":\"What role do colorectal cancer stem cells (CCSCs) play in CRC?\",\"answer\":\"CCSCs are important for tumor initiation, metastasis, and therapy resistance, making them potential targets for treatment.\"},{\"question\":\"What does the paper aim to provide about cancer stem cells in colorectal cancer?\",\"answer\":\"It provides an overview of current research on understanding CSCs in colorectal cancer, with emphasis on drug resistance mechanisms.\"}]","The Impact of Cancer Stem Cells in Colorectal Cancer - Review | PDF",1790040555,68]