[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330943-105":59,"doc-detail-330943-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-hippo-pathway-transcription-factors-yap-and-taz-play-hpv-type-dependent-roles-in-cervical-cancer","The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer","","The article investigates how the Hippo pathway transcription factors YAP and TAZ contribute to cervical cancer in an HPV-type dependent manner. It highlights that TAZ is dysregulated through a distinct mechanism from YAP, increasing proliferation, migration, and invasion by alternative cellular targets. Analyses of cervical cancer cell lines and patient biopsies show TAZ upregulation specifically in HPV18+ and HPV18-like cells, where TAZ knockdown reduces malignant behaviors. RNA sequencing further indicates distinct transcriptional targets, identifying TOGARAM2 as a key TAZ effector in HPV18+ cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-hippo-pathway-transcription-factors-yap-and-taz-play-hpv-type-dependent-roles-in-cervical-cancer/330943/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-hippo-pathway-transcription-factors-yap-and-taz-play-hpv-type-dependent-roles-in-cervical-cancer/330943.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus regarding YAP and TAZ in cervical cancer?","Question",{"text":112,"@type":113},"The study examines how YAP and TAZ transcription factors act through the Hippo pathway in a way that depends on the HPV type driving the cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does TAZ behavior differ between HPV18+ and HPV16+ cervical cancer cells?",{"text":117,"@type":113},"TAZ expression is significantly increased in HPV18+ and HPV18-like cells, and TAZ knockdown reduces proliferation, migration, and invasion only in HPV18+ cells, not HPV16+.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence shows that YAP and TAZ have non-redundant roles?",{"text":121,"@type":113},"RNA sequencing reveals distinct targets for YAP and TAZ, and YAP overexpression does not rescue the proliferation defect caused by TAZ depletion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330943,1790177152,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Article [https://doi.org/10.1038/s41467-024-49965-9](https://doi.org/10.1038/s41467-024-49965-9)  \nThe Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer  \nReceived: 11 September 2023  \n\n| Accepted: 21 June 2024 |\n| --- |\n| |\n| Check for updates |\n\nMolly R. Patterson 1,2 , Joseph A. Cogan 1,2, Rosa Cassidy1,2,  \nDaisy A. Theobald1,2, Miao Wang1,2, James A. Scarth 3, Chinedu A. Anene 3,4, Adrian Whitehouse 1,2, Ethan L. Morgan 5 & Andrew Macdonald 1,2   \nHuman papillomaviruses (HPVs) cause most cervical cancers and an increasing number of anogenital and oral carcinomas, with most cases caused by HPV16 or HPV18. HPV hijacks host signalling pathways to promote carcinogenesis. Understanding these interactions could permit identification of much-needed therapeutics for HPV-driven malignancies. The Hippo signalling pathway is important in HPV+ cancers, with the downstream effector YAP playing a prooncogenic role. In contrast, the significance of its paralogue TAZ remains largely uncharacterised in these cancers. We demonstrate that TAZ is dysregulated in a HPV-type dependent manner by a distinct mechanism to that of YAP and controls proliferation via alternative cellular targets. Analysis of cervical cancer cell lines and patient biopsies revealed that TAZ expression was only significantly increased in HPV18+ and HPV18-like cells and TAZ knockdown reduced proliferation, migration and invasion only in HPV18+ cells. RNAsequencing of HPV18+ cervical cells revealed that YAP and TAZ have distinct targets, suggesting they promote carcinogenesis by different mechanisms. Thus, in HPV18+ cancers, YAP and TAZ play non-redundant roles. This analysis identified TOGARAM2 as a previously uncharacterised TAZ target and demonstrates its role as a key effector of TAZ-mediated proliferation, migration and invasion in HPV18+ cancers.  \nCervical cancer remains a global public health problem, with the fourth most common incidence and mortality rates in women worldwide, accounting for ~ 604,000 new cases and ~ 340,000 deaths in 20201. Persistent infection with high-risk human papillomavirus (HR-HPV) type 16 accounts for most cervical cancers (~ 50%), with HPV18 being the second most common type, accounting for ~ 12% of squamous cell carcinomas as well as 37% of adenocarcinomas of the cervix2.  \nAlthough our understanding of HPV-mediated transformation has increased in recent years, there are currently no specific therapeutics  \ntargeting HPV or HPV-driven cancer. Thus, more research is required to identify ways to treat these cancers. Identifying how cell signalling pathways are dysregulated in HPV-driven malignancies may provide such therapeutic options2–5.  \nThe Hippo signalling pathway is a regulator of organ size and development, controlling the transcription of genes involved in cell growth and proliferation6. Although many stimuli can activate the pathway, the core kinase cascade consists of STK4/3 and LATS1/2 (together with SAV1 and MOB1) and culminates with phosphorylation  \n1School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. 2Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. 3Barts Cancer Institute, Queen Mary University of London, London, UK. 4Centre for Biomedical Science Research, Leeds Beckett University, Leeds, UK. 5School of Life Sciences, University of Sussex, Brighton, UK. [e-mail:](e-mail: molly.patterson@pennmedicine.upenn.edu)[ molly.patterson@pennmedicine.upenn.edu](e-mail: molly.patterson@pennmedicine.upenn.edu); [a.macdonald@leeds.ac.uk](a.macdonald@leeds.ac.uk)  \nand subsequent inactivation and degradation of the transcription factors YAP and TAZ7,8. Recent studies have highlighted the importance of this pathway evidenced by the crucial oncogenic functions of YAP9. Both HR-HPV E6 and E7 promote YAP stabilisation and activation, emphasising its importance in cervical cancer10–13. The beta papillomav","cbCaitIGRSCrdnW5","https://ap.wps.com/l/cbCaitIGRSCrdnW5","pdf",5185080,18,"English","# Background\n## HPV-driven cervical carcinogenesis\n## Hippo pathway and transcriptional regulation\n# Study findings\n## HPV-type dependent TAZ dysregulation\n## Effects of TAZ knockdown and proliferation impacts\n## Distinct YAP and TAZ transcriptional targets\n## Identification of TOGARAM2 as a TAZ target","[{\"question\":\"What is the main focus regarding YAP and TAZ in cervical cancer?\",\"answer\":\"The study examines how YAP and TAZ transcription factors act through the Hippo pathway in a way that depends on the HPV type driving the cancer.\"},{\"question\":\"How does TAZ behavior differ between HPV18+ and HPV16+ cervical cancer cells?\",\"answer\":\"TAZ expression is significantly increased in HPV18+ and HPV18-like cells, and TAZ knockdown reduces proliferation, migration, and invasion only in HPV18+ cells, not HPV16+.\"},{\"question\":\"What evidence shows that YAP and TAZ have non-redundant roles?\",\"answer\":\"RNA sequencing reveals distinct targets for YAP and TAZ, and YAP overexpression does not rescue the proliferation defect caused by TAZ depletion.\"}]","The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer | PDF",1789990831,45]