[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-376083-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-376083-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-hidden-power-of-black-pepper-exploring-piperines-role-in-cancer","The Hidden Power of Black Pepper: Exploring Piperine’s Role in Cancer","","Cancer develops through uncontrolled and dysregulated cell proliferation and migration, driven by intertwined genetic, environmental, and lifestyle determinants. Numerous pharmacological and natural compounds are being explored for prevention and treatment. Piperine, a bioactive alkaloid from black pepper (Piper nigrum L.), has attracted interest for its preventive and curative potential. Human cell-line studies and advanced animal tumor models indicate multiple mechanisms by which piperine may influence cancer development and metastasis. This review analyzes molecular and cellular pathways underlying piperine’s effects and its relevance across different cancer types.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-hidden-power-of-black-pepper-exploring-piperines-role-in-cancer/376083/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-hidden-power-of-black-pepper-exploring-piperines-role-in-cancer/376083.png","ImageObject",300,407,{"name":42,"@type":43},"Đào","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is piperine and where does it come from?","Question",{"text":63,"@type":64},"Piperine is an alkaloid responsible for black pepper’s aroma and pungent taste. 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The development of cancer is the result of the interaction of a number of factors, including genetic mutations, environmental factors and lifestyle habits. There are many pharmacological and natural compounds that can be used to prevent and/or treat cancer. Piperine, a naturally occurring compound with multiple therapeutic properties, is the primary bioactive component of black pepper (Piper nigrum L.), a member of the Piperaceae plant family. In recent years, it has attracted much interest as a potentially useful agent for the preventive and curative management of cancer. Results from studies of human cancer cell lines and advanced animal tumour models suggest that there are multiple pathways by which piperine may affect cancer development and metastasis. This review examines the molecular and cellular mechanisms through which piperine exerts its effects on cancer formation and progression, as well as its potential effects on various types of cancer.  \nKeywords Anticancer · Black pepper · Natural therapeutic agents · Piperine · Piper nigrum L  \nIntroduction  \nCancers constitute a family of diseases defined by the uncontrolled proliferation of cells, resulting from the loss of normal control over the processes of growth and division [1] . Cancer is now a significant public health concern, accounting for nearly one in six of all deaths (16.8%) and one in four deaths (22.8%) from non communicable diseases globally [2] . It is further estimated that 20 million new cases of cancer and 9.7 million cancer associated deaths occurred globally in 2022 [3] . In the last few years, a range of alternative strategies have been the subject of investigation in the context of cancer treatment, in addition to the established approaches of surgery, radiotherapy, and chemotherapy [4] . It is widely recognised that lifestyle factors such as avoiding smoking, maintaining a healthy weight, engaging in regular physical activity, limiting alcohol consumption and adhering to a nutritious diet can significantly reduce the risk of developing several types of cancer, particularly those strongly  \n* Nevin Sanlier [nevintekgul@gmail.com](nevintekgul@gmail.com)  \n1 Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, 06050 Altındag, Ankara, Turkey  \nassociated with modifiable behaviors such as lung, colorectal and breast cancer [5] . Moreover, the combination of specific phytochemicals, such as polyphenols and alkaloids extracted from medicinal plants with healthy nutritional patterns has shown potential in cancer prevention and adjunct therapy. These compounds are attracting attention due to their capacity to reduce cell proliferation, induce apoptosis, delay metastasis, and inhibit angiogenesis while exhibiting relatively low toxicity profiles [6] .  \nBlack pepper (Piper nigrum L.), historically referred to as the ‘king of spices’, is a member of the family Piperaceae and one of the most widely used spices globally. Black pepper is widely used in traditional medicine for its therapeutic properties in the treatment of many health problems such as headaches, rheumatic diseases, or sore throat and flu, as well as for improving blood circulation [7] . It contains piperine (1–piperoylpiperidine), an alkaloid responsible for its unique aroma and pungent taste, which has many potential health benefits [8]. Piperine, regarded as the principal bioactive constituent of black pepper, is documented to be most abundant in black pepper (Piper nigrum L., 9%), while it is also present at intermedia","cbCaip2dRFMhjR3o","https://ap.wps.com/l/cbCaip2dRFMhjR3o","pdf",968268,15,"English","# Introduction\n## Cancer as a public health concern\n## Lifestyle and phytochemical approaches\n# Piperine and black pepper background\n## Traditional uses and composition\n## Evidence for anticancer potential\n# Objective and review scope\n## Mechanisms and cancer progression","[{\"question\":\"What is piperine and where does it come from?\",\"answer\":\"Piperine is an alkaloid responsible for black pepper’s aroma and pungent taste. It is the principal bioactive constituent of black pepper (Piper nigrum L.).\"},{\"question\":\"How might piperine influence cancer development and metastasis?\",\"answer\":\"Studies suggest piperine may act through multiple pathways affecting cancer formation and metastasis. Proposed actions include regulating key signalling pathways and influencing processes such as proliferation, apoptosis, and angiogenesis.\"},{\"question\":\"Why is piperine’s clinical use in oncology still limited?\",\"answer\":\"Clinical oncology application remains limited, primarily due to pharmacokinetic constraints and gaps in mechanistic insights.\"}]","The Hidden Power of Black Pepper: Exploring Piperine’s Role in Cancer | PDF",1790217212,38]