[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329220-105":59,"doc-detail-329220-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-gut-microbiota-impacts-gastrointestinal-cancers-through-obesity-diabetes-and-chronic-inflammation","The Gut Microbiota Impacts Gastrointestinal Cancers through Obesity, Diabetes, and Chronic Inflammation","","The gut microbiota is central to human health, with growing evidence linking dysbiosis to obesity, diabetes, and chronic inflammatory conditions. This symbiotic network shapes metabolic balance and immune signaling, and chronic low-grade inflammation emerges as a shared driver of disease progression. In obesity and diabetes, microbial alterations relate to metabolic disruption, insulin resistance, and impaired glucose regulation. Chronic inflammation also acts as a recognized precursor to carcinogenesis, raising the question of whether microbial patterns overlap with colorectal and pancreatic cancer. This review synthesizes emerging evidence and highlights potential diagnostic, preventative, and therapeutic directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-gut-microbiota-impacts-gastrointestinal-cancers-through-obesity-diabetes-and-chronic-inflammation/329220/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-gut-microbiota-impacts-gastrointestinal-cancers-through-obesity-diabetes-and-chronic-inflammation/329220.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does gut microbiota dysbiosis relate to obesity and chronic inflammation?","Question",{"text":112,"@type":113},"Gut microbial dysbiosis is linked to obesity-related metabolic disruption and chronic low-grade inflammation, influencing metabolic and immune balance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the proposed role of gut microbiota in diabetes?",{"text":117,"@type":113},"Gut microbiota impacts insulin resistance and glucose metabolism, making microbial changes increasingly relevant to diabetes progression.",{"name":119,"@type":110,"acceptedAnswer":120},"How could chronic inflammation and gut microbiota connect to gastrointestinal cancers?",{"text":121,"@type":113},"Chronic inflammation is a recognized precursor to carcinogenesis, and gastrointestinal cancers like colorectal and pancreatic cancer are closely tied to inflammation and metabolic dysregulation, suggesting microbial signatures may overlap with precancerous or cancerous states.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329220,1790104051,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","life  \nReview  \nThe Gut Microbiota Impacts Gastrointestinal Cancers through Obesity, Diabetes, and Chronic Inflammation  \nKonstantin A. Rumyantsev , Vera V. Polyakova *, Irina V. Sorokina, Polina S. Feoktistova, Igor E. Khatkov, Natalia A. Bodunova and Lyudmila G. Zhukova  \nCitation: Rumyantsev, K.A.;  \nPolyakova, V.V.; Sorokina, I.V.; Feoktistova, P.S.; Khatkov, I.E.; Bodunova, N.A.; Zhukova, L.G. The Gut Microbiota Impacts Gastrointestinal Cancers through Obesity, Diabetes, and Chronic Inflammation. Life 2024, 14, 1219 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)life14101219  \nAcademic Editors: Milan Kolar and Pabulo H. Rampelotto  \nReceived: 12 August 2024  \nRevised: 9 September 2024  \nAccepted: 11 September 2024  \nPublished: 24 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nLoginov Moscow Clinical Scientific Center, 111123 Moscow, Russia  \n* [Correspondence: v.polyakova@mknc.ru](Correspondence: v.polyakova@mknc.ru)  \nAbstract: The gut microbiota’s pivotal role in human health is increasingly evident, particularly in chronic conditions like obesity, diabetes, and inflammatory diseases. This intricate symbiotic relationship influences metabolic balance and immune responses. Notably, gut microbial dysbiosisis linked to obesity’s metabolic disruption and chronic low-grade inflammation. Similarly, in diabetes, the microbiota’s impact on insulin resistance and glucose metabolism is becoming evident. Chronic inflammation, a common denominator in these conditions, is also a recognized precursor to carcinogenesis. This intersection prompts a compelling question: does the gut microbiota’s influence extend to gastrointestinal cancers like colorectal and pancreatic cancer? These malignancies are closely intertwined with inflammation and metabolic dysregulation. Exploring whether the microbial signatures associated with chronic conditions overlap with precancerous or cancerous states offers new perspectives. This article reviews emerging evidence on the interplay between the gut microbiota, chronic conditions, and gastrointestinal cancers. By elucidating these connections, we aim to uncover potential avenues for innovative diagnostic, preventative, and therapeutic strategies in colorectal and pancreatic cancer management.  \nKeywords: gut microbiota; obesity; diabetes; chronic inflammation  \n1. Introduction  \nThe human microbiome is a set of microbes, their genes, and their products that colonize the body from birth and are usually transferred to a child from its mother. The microbiota of each person is unique and differs both at the species and strain levels. The gut microbiota is an ecosystem consisting of a community of microorganisms living in our gastrointestinal tract (GI) from the oral cavity to the colon [1] . The role of the gut microbiota in diagnosing and monitoring the progress of different human diseases and health conditions has grown thanks to the broader use and decreasing cost of deepsequencing technologies [2] . The new approach to studying microbial communities has paved the way to new analytical depths, revealing connections between not only diseases of the GI but also cancers and systemic conditions.  \nCurrently, changes in the composition of the intestinal microbiota are associated with many morbid conditions, including diabetes mellitus and inflammatory bowel diseases. Growing evidence has indicated that the intestinal microbiota have key roles in the carcinogenesis of many tumor types [3] . It has been assumed that various molecular pathways of pathogenesis are affected, explaining how intestinal bacteria can be either protective against a disease or ","cbCaibFgJQBSiG8D","https://ap.wps.com/l/cbCaibFgJQBSiG8D","pdf",833170,"English","# Introduction\n## Gut microbiota and the human microbiome\n## Microbiota roles in disease diagnosis and carcinogenesis\n## Mechanisms: immune responses and clinical relevance","[{\"question\":\"How does gut microbiota dysbiosis relate to obesity and chronic inflammation?\",\"answer\":\"Gut microbial dysbiosis is linked to obesity-related metabolic disruption and chronic low-grade inflammation, influencing metabolic and immune balance.\"},{\"question\":\"What is the proposed role of gut microbiota in diabetes?\",\"answer\":\"Gut microbiota impacts insulin resistance and glucose metabolism, making microbial changes increasingly relevant to diabetes progression.\"},{\"question\":\"How could chronic inflammation and gut microbiota connect to gastrointestinal cancers?\",\"answer\":\"Chronic inflammation is a recognized precursor to carcinogenesis, and gastrointestinal cancers like colorectal and pancreatic cancer are closely tied to inflammation and metabolic dysregulation, suggesting microbial signatures may overlap with precancerous or cancerous states.\"}]","The Gut Microbiota Impacts Gastrointestinal Cancers through Obesity, Diabetes, and Chronic Inflammation | PDF",1789983131,25]