[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384117-105":59,"doc-detail-384117-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-glioblastoma-circularrnaome","The Glioblastoma CircularRNAome","","Glioblastoma is presented as an especially aggressive brain malignancy that drives the need for earlier diagnosis and more effective therapies. The article reviews circular RNAs (circRNAs), emphasizing their greater stability than linear RNAs and their capacity to regulate cancer biology by binding proteins and functioning as microRNA sponges. It synthesizes published evidence on how glioblastoma-related circRNAs influence proliferation, survival, migration, invasion, metastasis, metabolic reprogramming, and therapeutic resistance. It further connects circRNA actions to key oncogenic pathways such as MAPK, PI3K/AKT/mTOR, and Wnt, supporting circRNAs as future biomarkers and therapeutic targets or agents.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-glioblastoma-circularrnaome/384117/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-glioblastoma-circularrnaome/384117.png","ImageObject",300,407,{"name":92,"@type":93},"eBook King","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the clinical problem addressed regarding glioblastoma?","Question",{"text":112,"@type":113},"Glioblastoma is described as the most aggressive malignant brain cancer, with current therapies lacking significant efficacy and producing limited progression-free and overall survival benefits.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do circular RNAs play in glioblastoma according to the review?",{"text":117,"@type":113},"CircRNAs are highlighted as regulators that affect core cancer processes including proliferation, survival, migration, invasion, metastasis, metabolic reprogramming, and therapeutic resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"Which signaling pathways are discussed as being influenced by circRNAs in glioblastoma?",{"text":121,"@type":113},"The review connects circRNA regulatory functions to essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384117,1790472669,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Review  \nThe Glioblastoma CircularRNAome  \nAlexandru Tirpe 1,2, Cristian Streianu 2, Stefana Maria Tirpe 3, Anja Kocijancic 4, Radu Pirlog 1, Bianca Pirlog 5, Constantin Busuioc 6,7, Ovidiu-Laurean Pop 8 and Ioana Berindan-Neagoe 1, *  \nCitation: Tirpe, A.; Streianu, C.; Tirpe, S.M.; Kocijancic, A.; Pirlog, R.; Pirlog, B.; Busuioc, C.; Pop, O.-L.; Berindan-Neagoe, I. The Glioblastoma CircularRNAome. Int.  \nJ. Mol. Sci. 2023, 24, 14545. [https://](https://)[ ](https://)[doi.org/10.3390/ijms241914545](doi.org/10.3390/ijms241914545)  \nAcademic Editor: Chiara Laezza  \nReceived: 7 September 2023  \nRevised: 20 September 2023  \nAccepted: 21 September 2023  \nPublished: 26 September 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania; [altirpe@gmail.com](altirpe@gmail.com) (A.T.); [pirlog.radu@yahoo.com](pirlog.radu@yahoo.com) (R.P.)  \n2 The Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania; [crstreianu@gmail.com](crstreianu@gmail.com)  \n[3](3 Department of Neurology)[ Department of Neurology](3 Department of Neurology), [Ortenau-Klinikum Lahr](Ortenau-Klinikum Lahr), [Klostenstrasse 19](Klostenstrasse 19), [7933 Lahr](7933 Lahr), [Germany](Germany); [sciortea@gmail.com](sciortea@gmail.com)  \n4 Department of Microbiology, Oslo University Hospital, N-0424 Oslo, Norway; [akocijancic@gmail.com](akocijancic@gmail.com)  \n5 Department of Neurology, County Emergency Hospital, 400012 Cluj-Napoca, Romania; [byanemes@gmail.com](byanemes@gmail.com)  \n6 Department of Pathology, National Institute of Infectious Disease, 021105 Bucharest, Romania; [busuioc.constantin@gmail.com](busuioc.constantin@gmail.com)  \n7 Department of Pathology, Onco Team Diagnostic, 010719 Bucharest, Romania  \n8 Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University of Oradea,  \n410073 Oradea, Romania; [drovipop@yahoo.com](drovipop@yahoo.com)  \n* Correspondence: [ioana.neagoe@umfcluj.ro](ioana.neagoe@umfcluj.ro)  \nAbstract: Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents.  \nKeywords: circRNA; glioblastoma; ncRNA  \n1. Introduction  \nAlthough there are over 100 histologically different central nervous system (CNS) tumors, glioblastoma (GBM) remains the most aggressive malignant cancer of the brain. The 2021 statistics show that the combined glioblastoma incidence for all ages is 3.23 per 100,000 people, accounting for approximately 49% of all primary malignant CNS tumorsin all ages combined [1] . This poses a real problem, as current therapies lack significant efficacy, translated into a lack of considerable progr","cbCaikod9RAqe597","https://ap.wps.com/l/cbCaikod9RAqe597","pdf",1591412,16,"English","# 1. Introduction\n## Glioblastoma aggressiveness and clinical challenge\n## Classification: primary vs. secondary GBM\n## Genetic and epigenetic alterations\n## Molecular subtypes and gene-based profiling","[{\"question\":\"What is the clinical problem addressed regarding glioblastoma?\",\"answer\":\"Glioblastoma is described as the most aggressive malignant brain cancer, with current therapies lacking significant efficacy and producing limited progression-free and overall survival benefits.\"},{\"question\":\"What roles do circular RNAs play in glioblastoma according to the review?\",\"answer\":\"CircRNAs are highlighted as regulators that affect core cancer processes including proliferation, survival, migration, invasion, metastasis, metabolic reprogramming, and therapeutic resistance.\"},{\"question\":\"Which signaling pathways are discussed as being influenced by circRNAs in glioblastoma?\",\"answer\":\"The review connects circRNA regulatory functions to essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt.\"}]","The Glioblastoma CircularRNAome | PDF",1790261279]