[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-429731-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-429731-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-first-chinese-hb-m-saskatoon-case-with-low-oxygen-saturation-in-50-year-old-women-case-report","The first Chinese Hb M Saskatoon case with low oxygen saturation in 50-year-old women - Case report","","The article reports the first Chinese case of Hb M Saskatoon in a 50-year-old woman, highlighting low oxygen saturation as the primary presentation. Arterial blood gas and laboratory testing showed O2Sat at 78.9% alongside elevated methemoglobinemia (MetHb 12.1%) with additional abnormal findings. Gene sequencing confirmed the missense HBB variant HBB: c.190 C>T p. His64Tyr. The mutation has been documented worldwide in fewer than ten cases, without prior reports in China. The report summarizes clinical features and discusses possible physiological mechanisms.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-first-chinese-hb-m-saskatoon-case-with-low-oxygen-saturation-in-50-year-old-women-case-report/429731/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-first-chinese-hb-m-saskatoon-case-with-low-oxygen-saturation-in-50-year-old-women-case-report/429731.png","ImageObject",300,407,{"name":42,"@type":43},"Asher","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main clinical manifestation in the reported patient?","Question",{"text":63,"@type":64},"The primary manifestation was low oxygen saturation (O2Sat), measured at 78.9%. Cyanosis was also observed.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which genetic mutation was identified in this case?",{"text":68,"@type":64},"Gene sequencing identified the HBB missense mutation HBB: c.190 C>T, resulting in p. His64Tyr, described as Hb M Saskatoon disease.",{"name":70,"@type":61,"acceptedAnswer":71},"What additional hematology findings were reported beyond low oxygen saturation?",{"text":72,"@type":64},"The patient showed high methemoglobinemia (MetHb 12.1%) and other abnormal laboratory results, including dark red venous blood samples and mild anemia with normal MCV.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},429731,1791035136,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":101,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Annals of Hematology (2025) 104:6421–6426  \n[https://doi.org/10.1007/s00277-025-06631-4](https://doi.org/10.1007/s00277-025-06631-4)  \nCASE REPORT  \nThe first Chinese hb m-saskatoon [HBB: c.190 c >t p. His64Tyr] case with low oxygen saturation in 50-year-old women  \nYingjun Zhang1,2 · Ge Zhang1,2 · Lei Ye1,2 · Qingkai Dai1,2 · Luyun Peng1,2 · Rui Shi1,2 · Siqi Guo1,2 · Jiajing He1,2 · Hao Yang1,2 · Wenling Shang1,2 · Ke Huang3 · Liang Zhang4 · Yuefang Wang1,2  \nReceived: 16 March 2025 / Accepted: 11 September 2025 / Published online: 21 October 2025 © The Author(s) 2025  \nAbstract  \nWe reported the first Chinese case of Hb M Saskatoon in a 50-year-old female patient, with the primary manifestation of low oxygen saturation (O2Sat) (78.9%) as well as high methemoglobinemia (MetHb) (12.1%) and other abnormal results in laboratory tests. Gene sequencing revealed that the missense mutation is located in the HBB gene (HBB: c.190 C >Tp.His64Tyr), which was described as Hb M Saskatoon disease. This mutation has been reported worldwide in fewer than ten cases, and there have been no reports in China yet. Here, we provide a comprehensive report of all the clinical features of this patient and discuss the potential physiological mechanisms involved in this case.  \nKey words Hemoglobin · Hb M disease · Low oxygen saturation  \nAbbreviations  \nArg arginine Asn asparagine Cys cysteine Gln glutamine GSH glutathione Hb hemoglobin  \nHis histidine  \nLeu leucine  \nMetHb methemoglobinemia O2Sat oxygen saturation  \n􀀍 Liang Zhang [kidneyzl2018@foxmail.com](kidneyzl2018@foxmail.com)  \n􀀍 Yuefang Wang [505926169@qq.com](505926169@qq.com)  \n1 Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China  \n2 Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China  \n3 Air Force Hospital of Western Theater Command, PLA, Chengdu, Sichuan, China  \n4 Department of General Internal Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China  \nRET reticulocyte  \nSer serine  \nThr threonine  \nTyr tyrosine  \nMCV Mean Corpuscular Volume WBC White Blood cell  \nWDF WBC differential  \nWES Whole Exome Sequencing  \nIntroduction  \nHb M is a rare type of abnormal hemoglobin variant due to mutations in globin chains and substitutions of amino acids, leading to the increase of oxidized ferric state (Fe3+) in hemoglobin. Such mutations were inherited in an autosomal dominant manner. Patients with Hb M typically show cyanosis, dark brown blood or abnormal oximetry without fatal manifestations. Currently, almost 13 forms of Hb M were reported such as Hb M Boston, Osaka and Saskatoon with different mutations in alpha, beta or gamma chain, in which Hb M Saskatoon is an extremely rare type that even fewer than ten cases were reported worldwide. Currently, there have been no reports in China yet. Here, we reported the first Chinese Hb M Saskatoon case in Sichuan province with related syndromes. We aim to provide implications in  \ndiagnosing and treatment of this type of Hb M disease for clinical reference.  \nClinical case report  \nA 50-year-old female patient was referred to our institution for a surgical requirement due to a cystic lesion in the left adnexa. The patient indicated that she had low transcutaneous oxygen saturation over the past decades, which was diagnosed during a routine medical examination. Cyanosis was observed, but no other symptoms like fatigue, dyspnea, or shortness of breath were observed in her daily life.  \nPreoperative assessment of arterial blood gas showed the similar results as her self-statement. Low oxygen saturation (O2Sat) (78.9 %) as well as high methemoglobinemia (MetHb)(12.1%) were reported with other unusual outcomes (Table 1) . Her venous blood samples were dark red as shown in Figure 1.Throughout the blood routine test, she showed mild anemia (Hb10.9g/dL) with normal M","cbCaieYYDvQqADjY","https://ap.wps.com/l/cbCaieYYDvQqADjY","pdf",1082441,"English","# Abstract\n# Key words\n# Abbreviations\n# Introduction\n# Clinical case report\n## Preoperative assessment\n## Laboratory findings and diagnostics","[{\"question\":\"What was the main clinical manifestation in the reported patient?\",\"answer\":\"The primary manifestation was low oxygen saturation (O2Sat), measured at 78.9%. Cyanosis was also observed.\"},{\"question\":\"Which genetic mutation was identified in this case?\",\"answer\":\"Gene sequencing identified the HBB missense mutation HBB: c.190 C\\u003eT, resulting in p. His64Tyr, described as Hb M Saskatoon disease.\"},{\"question\":\"What additional hematology findings were reported beyond low oxygen saturation?\",\"answer\":\"The patient showed high methemoglobinemia (MetHb 12.1%) and other abnormal laboratory results, including dark red venous blood samples and mild anemia with normal MCV.\"}]","The first Chinese Hb M Saskatoon case with low oxygen saturation in 50-year-old women - Case report | PDF",1790650989,15]