[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333235-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333235-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-fibroblast-landscape-in-stomach-carcinogenesis","The Fibroblast Landscape in Stomach Carcinogenesis","","Single cell analyses define diverse fibroblast populations that emerge during stomach carcinogenesis. This review summarizes major genes expressed in fibroblasts and categorizes them into four key subpopulations, linking precancerous mucosal fibroblasts to the progression of metaplastic lineages toward cancer. Studies using single cell RNA sequencing and spatial transcriptomics reveal extensive cellular heterogeneity across stages, while fibroblast plasticity shapes metaplasia, dysplasia, and evolving carcinogenic microenvironments. It highlights increasing myofibroblasts in late phases and PDGFRA-expressing telocyte-like cells that expand near epithelial lineages.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-fibroblast-landscape-in-stomach-carcinogenesis/333235/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-fibroblast-landscape-in-stomach-carcinogenesis/333235.png","ImageObject",300,407,{"name":42,"@type":43},"Finn","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does single-cell research reveal about fibroblasts during stomach carcinogenesis?","Question",{"text":63,"@type":64},"Single-cell analyses define distinct fibroblast populations present across stages of stomach carcinogenesis and indicate substantial transcriptional heterogeneity.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How are fibroblast populations organized in this review?",{"text":68,"@type":64},"The review discusses major genes expressed and categorizes fibroblast populations into four major subpopulations.",{"name":70,"@type":61,"acceptedAnswer":71},"What cellular changes support the carcinogenic microenvironment in the stomach?",{"text":72,"@type":64},"Myofibroblast populations increase during late-stage carcinogenesis and PDGFRA-expressing telocyte-like cells expand during metaplasia and dysplasia near epithelial lineages, together shaping microenvironmental support.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333235,1790105892,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","REVIEW   \nThe Fibroblast Landscape in Stomach Carcinogenesis  \nEla W. Contreras-Panta, 1 ,2 ,3 Eunyoung Choi, 1 ,2 ,3 and James R. Goldenring 1 ,2 ,3 ,4  \n1Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee; 2Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; 3Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee; and 4Nashville VA Medical Center, Nashville, Tennessee  \nSUMMARY  \nSingle cell analyses have defined fibroblast populations present during stomach carcinogenesis. We discuss major genes expressed and the categorization of these fibroblast populations into 4 major subpopulations. Fibroblasts in the precancerous mucosa may drive progression of metaplastic lineages into cancer.  \nNumerous recent studies using single cell RNA sequencing and spatial transcriptomics have shown the vast cell heterogeneity, including epithelial, immune, and stromal cells, present in the normal human stomach and at different stages of gastric carcinogenesis. Fibroblasts within the metaplastic and dysplastic mucosal stroma represent key contributors to the carcinogenic microenvironment in the stomach. The heterogeneity of fibroblast populations is present in the normal stomach, but plasticity within these populations underlies their alterations in association with both metaplasia and dysplasia. In this review, we summarize and discuss efforts over the past several years to study the fibroblast components in human stomach from normal to metaplasia, dysplasia, and cancer. In the stomach, myofibroblast populations increase during late phase carcinogenesis and are a source of matrix proteins. PDGFRAexpressing telocyte-like cells are present in normal stomach and expand during metaplasia and dysplasia in close proximity with epithelial lineages, likely providing support for both normal and metaplastic progenitor niches. The alterations in fibroblast transcriptional signatures across the stomach carcinogenesis process indicate that fibroblast populations are likely as plastic as epithelial populations during the evolution of carcinogenesis. (Cell Mol Gastroenterol Hepatol 2024;17:671–678; [https://doi.org/10.1016/](https://doi.org/10.1016/)[ ](https://doi.org/10.1016/)[j.jcmgh.2024.02.001](j.jcmgh.2024.02.001))  \nKeywords: SPEM; metaplasia; dysplasia; PDGRFA; telocyte.  \nEpithelial alterations during the induction of meta  \nplasia in the stomach have received considerable attention recently, and other studies have noted the association of these mucosal changes with the influence of M2-macrophages and type 2-innate lymphoid cells.1–6 The intestinal type of gastric cancer develops within a field of oxyntic atrophy and metaplasia,7 and recent studies have redefined a sequence of metaplastic changes initiated by pyloric metaplasia in response to parietal cell loss.5 Continued inflammation leads to the progression of  \npyloric metaplasia into incomplete intestinal metaplasia, which is most associated with the development of dysplasia and adenocarcinoma.8–11 Linked with alterations in mucosal lineages, there is a considerable expansion of stromal elements, but relatively less is known about the changes in fibroblast populations in the metaplastic and dysplastic mucosa. In this article, we will discuss recent investigations related to fibroblast populations in the stomach under normal conditions and during gastric carcinogenesis (Table 1) .  \nFibroblasts in Normal Human Gastric Mucosa  \nStromal cells represent mesenchymal lineages found in the interstitial lamina propria of major organs and connective tissues.19 Stromal cells consist of multiple cell types, including fibroblasts, myofibroblasts, and pericytes, and have distinguishing features of elongated cytoplasmic projections and spindle-shaped nuclei.20 Fibroblasts produce extracellular matrix, including collagen, proteoglycans, and fibronectin.21 In gastrointestinal organs, fibroblasts are generally known to ma","cbCaipQuTyfRvMd6","https://ap.wps.com/l/cbCaipQuTyfRvMd6","pdf",1951074,"English","# The Fibroblast Landscape in Stomach Carcinogenesis\n## Fibroblasts in Normal Human Gastric Mucosa\n## Fibroblast Populations Across Gastric Carcinogenesis","[{\"question\":\"What does single-cell research reveal about fibroblasts during stomach carcinogenesis?\",\"answer\":\"Single-cell analyses define distinct fibroblast populations present across stages of stomach carcinogenesis and indicate substantial transcriptional heterogeneity.\"},{\"question\":\"How are fibroblast populations organized in this review?\",\"answer\":\"The review discusses major genes expressed and categorizes fibroblast populations into four major subpopulations.\"},{\"question\":\"What cellular changes support the carcinogenic microenvironment in the stomach?\",\"answer\":\"Myofibroblast populations increase during late-stage carcinogenesis and PDGFRA-expressing telocyte-like cells expand during metaplasia and dysplasia near epithelial lineages, together shaping microenvironmental support.\"}]","The Fibroblast Landscape in Stomach Carcinogenesis | PDF",1790001595]