[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380751-105":59,"doc-detail-380751-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-evolving-landscape-of-salivary-gland-tumors","The evolving landscape of salivary gland tumors","","Salivary gland cancers represent a rare but histologically diverse spectrum of malignancies, ranging from indolent forms to highly aggressive disease with substantial morbidity and mortality. Surgical resection remains central, while radiation therapy and systemic treatments are integral to comprehensive care. Due to rarity and heterogeneity, management is best delivered through multidisciplinary programs. This review summarizes current standards of care and emerging research aimed at improving patient outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-evolving-landscape-of-salivary-gland-tumors/380751/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-evolving-landscape-of-salivary-gland-tumors/380751.png","ImageObject",300,407,{"name":92,"@type":93},"awa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are salivary gland cancers difficult to manage clinically?","Question",{"text":112,"@type":113},"They are rare and histologically heterogeneous, spanning indolent to aggressive tumor types. This makes individualized, multidisciplinary care important.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do surgery, radiation, and systemic therapy play?",{"text":117,"@type":113},"Surgical resection is the mainstay, while radiation and systemic therapy are also critical components of the overall care paradigm.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the most common presenting symptom of salivary malignancy?",{"text":121,"@type":113},"A painless parotid or neck mass is the most common presenting symptom.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380751,1790862043,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":36,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},3985747858093,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>CA Cancer J Clin. Author manuscript; available in PMC 2024 March 29. |\n| --- | --- |\n\nPublished in final edited form as:  \nCA Cancer J Clin. 2023 ; 73(6): 597–619. doi:10.3322/caac.21807 .  \nThe evolving landscape of salivary gland tumors  \nConor E. Steuer, MD 1 , Glenn J. Hanna, MD2 , Kartik Viswanathan, MD, PhD3 , James E. Bates, MD4 , Azeem S. Kaka, MD5 , Nicole C. Schmitt, MD5 , Alan L. Ho, MD6 , Nabil F. Saba, MD7  \n1 Department of Hematology-Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA  \n2 Dana Farber Cancer Institute, Harvard University, Cambridge, Massachusetts, USA  \n3 Department of Pathology and Laboratory Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA  \n4 Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA  \n5 Department of Otolaryngology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA  \n6Memorial Sloan Kettering Cancer Center, New York, New York, USA  \n7Winship Cancer Institute of Emory University, Atlanta, Georgia, USA  \nAbstract  \nSalivary gland cancers are a rare, histologically diverse group of tumors. They range from indolent to aggressive and can cause significant morbidity and mortality. Surgical resection remains the mainstay of treatment, but radiation and systemic therapy are also critical parts of the care paradigm. Given the rarity and heterogeneity of these cancers, they are best managed in a multidisciplinary program. In this review, the authors highlight standards of care as well as exciting new research for salivary gland cancers that will strive for better patient outcomes.  \nKeywords  \ncancer; head and neck; multimodality; salivary gland carcinoma; targeted therapy   \nEPIDEMIOLOGY OF SALIVARY GLAND MALIGNANCIES  \nSalivary gland malignancies are uncommon, comprising approximately 6%–8% of all head and neck cancers.1 Although wide variations in incidence have been reported around the world, depending on the population studied, salivary gland malignancies occur at an  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \nCorrespondence: Conor E. Steuer, Winship Cancer Institute of Emory University, 1365 Clifton Road NE, Room C-2110, Atlanta, GA 30322, [USA. csteuer@emory.edu](USA. csteuer@emory.edu).  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nSteuer et al. Page 2  \nincidence of approximately 1.1 cases per 100,000 individuals in the United States.2 At younger ages, women seem to have a higher prevalence; however, generally speaking, this sex distribution difference plateaus because of an increase in the prevalence of certain malignancies among older men, particularly salivary duct carcinoma (SDC) and metastatic squamous cell carcinoma.2 Among the various histologic types, mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy, followed by adenoid cystic carcinoma (ADCC), and acinic cell carcinoma (AciCC) (Table 1) .  \nThe development of salivary gland neoplasms is multifactorial, involving complex environmental and genetic interactions.3 lonizing radiation, chemical exposure, obesity, autoimmune disorders, and viral infections (such as Epstein-Barr virus in lymphoepithelial carcinoma) have been implicated, although direct links have yet to be established. Mutations in tumor suppressors/oncogenes and chromosomal translocations can also promote the development of salivary gland neoplasms (both benign and malignant) .  \nANATOMY OF THE SALIVARY GLAND  \nThe salivary gland unit is composed of luminal ductal cells and is surrounded by abluminalmyoepithelial cells or no","cbCaicPe3WV4JlEa","https://ap.wps.com/l/cbCaicPe3WV4JlEa","pdf",1003515,"English","# Abstract\n# Epidemiology of Salivary Gland Malignancies\n# Anatomy of the Salivary Gland\n# Clinical Presentation\n# Diagnosis of Salivary Gland Carcinomas","[{\"question\":\"Why are salivary gland cancers difficult to manage clinically?\",\"answer\":\"They are rare and histologically heterogeneous, spanning indolent to aggressive tumor types. This makes individualized, multidisciplinary care important.\"},{\"question\":\"What role do surgery, radiation, and systemic therapy play?\",\"answer\":\"Surgical resection is the mainstay, while radiation and systemic therapy are also critical components of the overall care paradigm.\"},{\"question\":\"What is the most common presenting symptom of salivary malignancy?\",\"answer\":\"A painless parotid or neck mass is the most common presenting symptom.\"}]","The evolving landscape of salivary gland tumors | PDF",1790241878,101]