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This study assessed the effect of a six-week adjuvant AC chemotherapy regimen (doxorubicin and cyclophosphamide) on serum magnesium and the calcium (Ca)/magnesium ratio in breast cancer patients. Serum magnesium and calcium were measured spectrophotometrically, while hs-CRP was measured by ELISA to examine associations with inflammatory status.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-evaluation-of-serum-magnesium-and-calciummagnesium-ratio-in-patients-with-breast-cancer-receiving-adjuvant-chemotherapy/435523/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-evaluation-of-serum-magnesium-and-calciummagnesium-ratio-in-patients-with-breast-cancer-receiving-adjuvant-chemotherapy/435523.png","ImageObject",300,407,{"name":92,"@type":93},"jay","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main aim of the study?","Question",{"text":112,"@type":113},"To evaluate how a six-week adjuvant AC chemotherapy affects serum magnesium and the Ca/Mg ratio in patients with breast cancer receiving treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were serum magnesium and Ca/Mg ratio measured?",{"text":117,"@type":113},"Serum magnesium and calcium levels were determined spectrophotometrically, and the calcium/magnesium ratio was evaluated based on these measurements.",{"name":119,"@type":110,"acceptedAnswer":120},"What relationship did the study observe between hs-CRP and magnesium?",{"text":121,"@type":113},"Patients with higher hs-CRP values after treatment showed decreased serum magnesium levels, indicating an association between lower magnesium and increased inflammation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435523,1791010625,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},3985747858866,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","© 2025 Greater Poland Cancer Centre. Published by Via Medica.  \nAll rights reserved. e-ISSN 2083–4640  \nISSN 1507–1367  \nISSN: 1507–1367  \nRESEARCH PAPER  \nReports of Practical Oncology and Radiotherapy 2025, Volume 30, Number 6, pages: 816–827  \nDOI: 10.5603/rpor.108613  \nSubmitted: 23.04.2025  \nAccepted: 15.09.2025  \nThe evaluation of serum magnesium and calcium/magnesium ratio in patients with breast cancer receiving adjuvant  \nchemotherapy  \nJoanna Grupińska1, 2, Witold Kycler3, Dominik Dzieniszewski4, Elżbieta Kaja1, Agata Kubicka5, 6, Bogna Gryszczyńska1, Jacek J. Brzeziński3, Maria Iskra1, Dorota Formanowicz1, Natalia Idaszewska7,  \nEwa Leporowska8, Magdalena Budzyń1  \n1Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland 2Hospital Pharmacy, Greater Poland Cancer Centre, Poznan, Poland  \n3Department of Oncological Surgery of Gastrointestinal Diseases, Greater Poland Cancer Centre, Poznan, Poland 4Molecular and Biochemical Basis of Diseases, The Student Scientific Society of Poznan University of Medical Sciences, Poznan, Poland 5Department of Cancer Pathology, Greater Poland Cancer Centre, Poznan, Poland 6Department of Tumor Pathology and Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland 7Institute of Working Machines and Motor Vehicles, Poznan University of Technology, Poznan, Poland 8Department of Laboratory Diagnostics, Greater Poland Cancer Centre, Poznan, Poland  \nABSTRACT  \nBackground: Magnesium (Mg) deficiency may promote tumor growth and metastasis, hence the need to monitor and possibly normalize its level during treatment is emphasized. Therefore, our study aimed to assess the effect of a six-week adjuvant chemotherapy on serum Mg and calcium (Ca)/Mg ratio in patients with breast cancer.  \nMaterials and methods: The study included a group of 80 women with breast cancer who were qualified for adjuvant chemotherapy in the AC regimen (doxorubicin and cyclophosphamide). Serum magnesium and calcium levels were determined spectrophotometrically. Serum high-sensitivity C-reactive protein (hs-CRP) was measured using enzyme-linked immunosorbent assay (ELISA) .  \nResults: In the postoperative period, decreased serum magnesium and increased Ca/Mg ratio were observed in breast cancer women compared to healthy controls. After six weeks of AC chemotherapy, magnesium levels increased significantly, reaching a lower reference value. The same trend was noticed for the Ca/Mg ratio, which increased slightly but remained higher than in the control group. In patients with higher values of hs-CRP after treatment, decreased serum magnesium level was observed.  \nConclusions: Our study showed that the postoperative period is associated with magnesium deficiency in breast cancer patients. However, AC chemotherapy tends to normalize its concentration. During treatment, low magnesium concentration was associated with increased hs-CRP levels. This finding confirms that magnesium deficiency may induce inflammation, which has been implicated in tumor growth and metastasis. However, further research is needed to explain the role of magnesium in tumor development clearly.  \nKeywords: breast cancer; chemotherapy; inflammation; magnesium and calcium balance Rep Pract Oncol Radiother 2025;30(6):816–827  \nAddress for correspondence: Joanna Grupińska, Greater Poland Cancer Centre, 15 Garbary Street, 61–866 Poznan, Poland, tel.: (+48) 61 885 0335; [e-mail: joanna.grupinska@wco.pl](e-mail: joanna.grupinska@wco.pl)  \nThis article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially  \n816 [https://journals.viamedica.pl/rpor](https://journals.viamedica.pl/rpor)  \nIntroduction  \nBreast cancer is currently o","cbCailtoBYoP3zW1","https://ap.wps.com/l/cbCailtoBYoP3zW1","pdf",610604,12,"English","# Abstract\n## Background\n## Materials and methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the main aim of the study?\",\"answer\":\"To evaluate how a six-week adjuvant AC chemotherapy affects serum magnesium and the Ca/Mg ratio in patients with breast cancer receiving treatment.\"},{\"question\":\"How were serum magnesium and Ca/Mg ratio measured?\",\"answer\":\"Serum magnesium and calcium levels were determined spectrophotometrically, and the calcium/magnesium ratio was evaluated based on these measurements.\"},{\"question\":\"What relationship did the study observe between hs-CRP and magnesium?\",\"answer\":\"Patients with higher hs-CRP values after treatment showed decreased serum magnesium levels, indicating an association between lower magnesium and increased inflammation.\"}]","The evaluation of serum magnesium and calcium/magnesium ratio in patients with breast cancer receiving adjuvant chemotherapy | PDF",1790673964]