[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375692-105":59,"doc-detail-375692-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-eradication-of-carcinogenic-viruses-in-established-solid-cancers-hypothesis","The Eradication of Carcinogenic Viruses in Established Solid Cancers - Hypothesis","","Carcinogenic viruses (oncoviruses) can initiate cancer, but their effects on established disease vary: some prolong survival while others shorten it. This study classifies oncoviruses by whether they induce strong or weak CD8+ T cell responses in non-cancerous tissues, showing the classification helps predict prognosis in solid cancers. It suggests that, for established tumors, only viruses with weak CD8+ T cell reactions should be eradicated. The model correctly forecasts survival effects for six of seven known oncoviruses, highlighting immune modulation’s prognostic impact.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-eradication-of-carcinogenic-viruses-in-established-solid-cancers-hypothesis/375692/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-eradication-of-carcinogenic-viruses-in-established-solid-cancers-hypothesis/375692.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does the study classify carcinogenic viruses (oncoviruses)?","Question",{"text":112,"@type":113},"It groups oncoviruses into two categories based on whether they induce a strong or weak CD8+ T cell reaction in non-cancerous tissues.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the classification predict about established solid cancers?",{"text":117,"@type":113},"The classification is presented as useful for predicting how oncoviruses affect solid cancer prognosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the proposed eradication strategy for established tumors?",{"text":121,"@type":113},"The study suggests that only viruses inducing a weak CD8+ T cell reaction should be eradicated in established solid tumors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375692,1790669450,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Journal of Inflammation Research Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article HYPOTHESIS  \nThe Eradication of Carcinogenic Viruses in Established Solid Cancers  \nZeev Elkoshi  \nResearch and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, Israel Correspondence: Zeev Elkoshi, Email [zeev.elkoshi@gmail.com](zeev.elkoshi@gmail.com)  \n\n| Abstract: Carcinogenic viruses (oncoviruses) can initiate cancer, but their impact on established cancer varies. Some of these viruses prolong survival while others shorten it. This study classifies oncoviruses into two categories: viruses which induce a strong CD8+T cell reaction in non-cancerous tissues, and viruses which induce a weak CD8+ T cell reaction in non-cancerous tissues. The classification proves useful in predicting the effect of oncoviruses on the prognosis of solid cancers. Therefore, while eliminating carcinogenic viruses in healthy individuals (for example by immunization) may be important for cancer prevention, this study suggests that only viruses which induce a weak CD8+ T cell reaction should be eradicated in established solid tumors. The model correctly predicts the effect of oncoviruses on survival for six out of seven known oncoviruses, indicating that immune modulation by oncoviruses has a prominent effect on prognosis. It seems that CD8+ T cell response to oncoviruses observed in infected benign tissues is retained in infected tumors. Clinical significance: the effect of oncoviruses on solid cancer prognosis can be predicted with confidence based on immunological responses when clinical data are unavailable.\u003Cbr>Keywords: carcinogenic viruses, oncoviruses, cancer prognosis, CD8+ T cell, Treg cells |\n| --- |\n| Introduction\u003Cbr>Carcinogenic viruses drive the initiation of several types of cancer. Human papillomavirus (HPV) drives cervical cancer, head and neck cancer, and other less common cancer types such as vulva, vagina, penis, anus, and rectum cancers. Hepatitis B virus (HBV) and hepatitis C virus (HCV) drive hepatocellular carcinoma (HCC), human gamma herpesvirus 8 (HHV-8) triggers Kaposi’s sarcoma, human T-cell lymphoma virus 1 (HTLV1) triggers adult T-cell lymphoma/leukemia (ATLL), Epstein–Barr virus (EBV) triggers Burkitt’s lymphoma, nasopharyngeal carcinoma and Hodgkin’s lymphoma (HL), Merkel cell polyomavirus (MCPyV) induces Merkel cell carcinoma (MCC) .1 HBV and HPV infections are responsible for 23–59% of HCC cases and for 100% of cervical cancer cases, respectively.1 EBV is detected in the tumor tissue of almost 100% of the cases of endemic Burkitt lymphoma. Evidence of HTLV-1 infection was found in at least 90% of ATLL cases,2 HHV-8 is present in 80– 95% of Kaposi sarcoma lesions.3 MCPyV was detected in 77% of all MCCs.4 Although different carcinogenic agents use different mechanisms to induce their tumorigenic effects, they may broadly be divided into two classes: direct carcinogens which express viral oncogenes that directly contribute to cancer cell transformation (HPV, HTLV-1, EBV, MCPyV, and HHV-8), and indirect carcinogens that presumably cause cancer through chronic infection and inflammation, which eventually leads to carcinogenic mutations in host cells (HBV, HCV) .1 , 5 Oncoviruses hijack host cycle regulation machinery to promote their own genomic replication. Presumably, as part of this process, viruses target anti-cancer genes such as p53 and RB1 to delay host cell apoptosis, facilitating efficient virus production and export before cell death.5\u003Cbr>Viruses elicit strong innate immune responses by activating diverse pathogen recognition receptors (PRRs), including toll-like receptors (TLR) on plasma or endosomal membranes, and cytoplasmic receptors such as cGAS for viral DNA, and RIG-I and MDA-5 for viral RNA. These receptors initiate separate signaling cascades that converge to activate transcription factors. This activation results in the expression of pro-inflammatory cytokines, |\n","cbCaiqS4oUMtiKEz","https://ap.wps.com/l/cbCaiqS4oUMtiKEz","pdf",2382270,13,"English","# Abstract\n# Introduction","[{\"question\":\"How does the study classify carcinogenic viruses (oncoviruses)?\",\"answer\":\"It groups oncoviruses into two categories based on whether they induce a strong or weak CD8+ T cell reaction in non-cancerous tissues.\"},{\"question\":\"What does the classification predict about established solid cancers?\",\"answer\":\"The classification is presented as useful for predicting how oncoviruses affect solid cancer prognosis.\"},{\"question\":\"What is the proposed eradication strategy for established tumors?\",\"answer\":\"The study suggests that only viruses inducing a weak CD8+ T cell reaction should be eradicated in established solid tumors.\"}]","The Eradication of Carcinogenic Viruses in Established Solid Cancers - Hypothesis | PDF",1790215793,33]