[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331709-105":59,"doc-detail-331709-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-emerging-scenario-of-ferroptosis-in-pancreatic-cancer-tumorigenesis-and-treatment-review","The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment - review","","Pancreatic cancer remains one of the most lethal forms of cancer, and effective drug treatments are still lacking. Ferroptosis, a non-apoptotic programmed cell death mode, has drawn growing attention for its relationship with pancreatic cancer. Clarifying how ferroptosis contributes to tumorigenesis and shapes therapeutic responses can support more effective clinical trials while potentially limiting side effects and drug resistance. This review also discusses ferroptosis involvement in pancreatitis and insulin resistance, linking it to risk of related pancreatic cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-emerging-scenario-of-ferroptosis-in-pancreatic-cancer-tumorigenesis-and-treatment-review/331709/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-emerging-scenario-of-ferroptosis-in-pancreatic-cancer-tumorigenesis-and-treatment-review/331709.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is ferroptosis considered important in pancreatic cancer research?","Question",{"text":112,"@type":113},"Ferroptosis is a non-apoptotic, iron-dependent programmed cell death mode, and its dysfunction has been associated with processes relevant to pancreatic cancer such as tumor suppression and immune function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does ferroptosis influence tumorigenesis and treatment strategies for pancreatic cancer?",{"text":117,"@type":113},"Understanding ferroptosis roles in pancreatic cancer tumorigenesis and treatment may enable more effective clinical trials and therapies, while potentially minimizing side effects and limiting drug resistance.",{"name":119,"@type":110,"acceptedAnswer":120},"What connections does the review discuss between ferroptosis, pancreatitis, and insulin resistance?",{"text":121,"@type":113},"The review addresses how ferroptosis is implicated in the development of pancreatitis and insulin resistance, suggesting ferroptosis may contribute to the risk of pancreatic cancers related to these conditions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331709,1790141895,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Review  \nThe Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment  \nHao Lyu 1,2,†, Jinghua Kong 1,2,†, Jiasi Chen 1,2, Rui Zhang 1,2, Shuai Xiao 1,2, Dong Guo 1,2, Qi Zhang 1,2, Xing-Zhen Chen 3, Jingfeng Tang 1,2, * and Cefan Zhou 1,2, *  \n1 National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China  \n2 Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China  \n3 Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada  \n* [Correspondence: jingfeng_hut@163.com](Correspondence: jingfeng_hut@163.com) (J.T.); [cefan@hbut.edu.cn](cefan@hbut.edu.cn) (C.Z.); Tel./Fax: +86-027-5975-0472 (C.Z.)† These authors contributed equally to this work.  \nAbstract: Pancreatic cancer remains one of the most lethal forms of cancer. Currently, there is a lack of effective drug treatments for pancreatic cancer. However, as a newly discovered form of non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to pancreatic cancer. Understanding the role of ferroptosis in the tumorigenesis and treatment of pancreatic cancer may enable more effective clinical trials and treatments for pancreatic cancer and may minimize side effects or restrict the emergence of drug resistance. In this review, we summarize the current knowledge regarding the process and underlying mechanisms of ferroptosis, as well as its dual role in both promoting tumorigenesis and facilitating treatment strategies for pancreatic cancer. Additionally, how ferroptosis is implicated in the development of pancreatitis and insulin resistance, indicating that ferroptosis may play an important role in the risk of pancreatitis-and insulin-resistance-related pancreatic cancers, is also addressed.  \nCitation: Lyu, H.; Kong, J.; Chen, J.; Zhang, R.; Xiao, S.; Guo, D.; Zhang, Q.; Chen, X.-Z.; Tang, J.; Zhou, C. The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment. Int. J. Mol. Sci. 2024, 25, 13334. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms252413334  \nAcademic Editor: Pinar Uysal-Onganer  \nReceived: 25 November 2024  \nRevised: 10 December 2024  \nAccepted: 10 December 2024  \nPublished: 12 December 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nKeywords: pancreatic cancer; ferroptosis; tumorigenesis; drug resistance; immunotherapy  \n1. Introduction  \nPancreatic cancer (PC) is a highly malignant tumor of the digestive system and is the third leading cause of death for men and women in the United States, with a 5-year survival rate of less than 11%[1] . It is estimated that PC will become the second leading cause of cancer-related deaths by 2030 [2] . Pancreatic cancer includes a variety of different classes of malignant tumors originating from the exocrine or endocrine tissues of the pancreas. The most common is pancreatic adenocarcinoma, accounting for approximately 85% of cases [3] . Currently, the screening methods for pancreatic cancer are relatively limited. The majority of patients do not have a single attributable risk factor, further complicating the diagnosis; localized disease is mostly asymptomatic or associated with ambiguous symptoms, and the anatomical location of the pancreas is inaccessible for routine clinical monitoring [4] . For high-risk populations such as individuals","cbCaipukoaWUsZci","https://ap.wps.com/l/cbCaipukoaWUsZci","pdf",2661894,22,"English","# Introduction\n## Ferroptosis and its relevance to pancreatic cancer\n### Key clinical challenges in pancreatic cancer\n### Mechanistic roles of ferroptosis (iron, ROS, lipids)\n# Ferroptosis mechanisms and regulation (overview)\n## Membrane damage and cell death pathways\n## External and internal pathways (system Xc−, iron transport)\n## Epigenetic and non-epigenetic regulation","[{\"question\":\"Why is ferroptosis considered important in pancreatic cancer research?\",\"answer\":\"Ferroptosis is a non-apoptotic, iron-dependent programmed cell death mode, and its dysfunction has been associated with processes relevant to pancreatic cancer such as tumor suppression and immune function.\"},{\"question\":\"How does ferroptosis influence tumorigenesis and treatment strategies for pancreatic cancer?\",\"answer\":\"Understanding ferroptosis roles in pancreatic cancer tumorigenesis and treatment may enable more effective clinical trials and therapies, while potentially minimizing side effects and limiting drug resistance.\"},{\"question\":\"What connections does the review discuss between ferroptosis, pancreatitis, and insulin resistance?\",\"answer\":\"The review addresses how ferroptosis is implicated in the development of pancreatitis and insulin resistance, suggesting ferroptosis may contribute to the risk of pancreatic cancers related to these conditions.\"}]","The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment - review | PDF",1789994796,55]