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H19 shows context-dependent dual roles in tumorigenesis, acting as either an oncogene or a tumor suppressor. In ovarian cancer, H19 promotes tumor growth, metastasis, and chemoresistance via signaling pathway modulation and microRNA interactions. In endometrial cancer, it suppresses proliferation, induces apoptosis, and regulates epithelial-mesenchymal transition. H19 is also implicated in cervical and breast cancer through effects on proliferation, invasion, and immune evasion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-emerging-roles-of-long-non-coding-rna-lncrna-h19-in-gynecologic-cancers/326628/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-emerging-roles-of-long-non-coding-rna-lncrna-h19-in-gynecologic-cancers/326628.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What kinds of gynecologic cancers are associated with lncRNA H19?","Question",{"text":112,"@type":113},"H19 has been linked to ovarian, endometrial, cervical, and breast cancers, with roles in tumor development and progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can H19 act differently across cancer types?",{"text":117,"@type":113},"H19 can function as an oncogene or a tumor suppressor depending on the specific cancer context and type under investigation.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is H19 considered important for diagnosis or prognosis?",{"text":121,"@type":113},"Its expression levels are reported to correlate with clinical parameters and patient outcomes, supporting its potential as a diagnostic and prognostic biomarker.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326628,1790915098,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Ghasemian etal. BMC Cancer (2024) 24:4 [https://doi.org/10.1186/s12885-023-11743-z](https://doi.org/10.1186/s12885-023-11743-z)  \nBMC Cancer  \n REVIEW Open Access  \nThe emerging roles of long non-coding RNA  (lncRNA) H19 in gynecologic cancers  \nMajid Ghasemian1†, Mojtaba Zehtabi2†, Mahrokh Abouali Gale Dari3, Fatemeh Khojasteh Pour4,  \nGhasem AziziTabesh5, Farideh Moramezi6, Razieh Mohammad Jafari6, Mojgan Barati6, Shahab Uddin7,8 and Maryam Farzaneh6*  \nAbstract  \nLong non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initia  \ntion and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, and breast cancers. H19 exhibits a complex array of mechanisms, demonstrating dualistic effects on tumorigenesis as it can function as both an oncogene and a tumor suppressor, contingent upon the specific context and type of cancer being investigated. In ovarian cancer, H19 promotes tumor growth, metastasis, and chemoresistance through modulation of key signaling pathways and interaction with microRNAs. Conversely, in endometrial cancer, H19 acts as a tumor suppressor by inhibiting proliferation, inducing apoptosis, and regulating epithelial-mesenchymal transition. Additionally, H19 has been implicated in cervical and breast cancers, where it influences cell proliferation, invasion, and immune evasion. Moreover, H19 has potential as a diagnostic and prognostic biomarker for gynecologic cancers, with its expression levels correlating with clinical parameters and patient outcomes. Understanding the functional roles of H19 in gynecologic cancers is crucial for the development of targeted therapeutic strategies and personalized treatment approaches. Further investigation into the intricate molecular mechanisms underlying H19’s involvement in gynecologic malignancies is warranted to fully unravel its therapeutic potential and clinical implications. This review aims to elucidate the functional roles of H19 in various gynecologic malignancies.  \nKeywords LncRNAs, H19, Gynecologic cancer, Tumorigenesis, Biomarker  \n†Majid Ghasemian and Mojtaba Zehtabi contributed equally.  \n*Correspondence:  \nMaryam Farzaneh [maryamfarzaneh2013@yahoo.com](maryamfarzaneh2013@yahoo.com)  \n1 Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran  \n2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran  \n3 Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran  \n4 Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran  \n5 Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \n6 Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran  \n7 Translational Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar  \n8 Department of Biosciences, Integral University, Lucknow, Uttar Pradesh 22602, India  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/","cbCaiiyHEm9xJLRx","https://ap.wps.com/l/cbCaiiyHEm9xJLRx","pdf",1477222,14,"English","# Abstract\n# Introduction\n## Gynecological cancers and global health burden\n## Risk factors and associations\n## Multidisciplinary diagnosis and treatment","[{\"question\":\"What kinds of gynecologic cancers are associated with lncRNA H19?\",\"answer\":\"H19 has been linked to ovarian, endometrial, cervical, and breast cancers, with roles in tumor development and progression.\"},{\"question\":\"How can H19 act differently across cancer types?\",\"answer\":\"H19 can function as an oncogene or a tumor suppressor depending on the specific cancer context and type under investigation.\"},{\"question\":\"Why is H19 considered important for diagnosis or prognosis?\",\"answer\":\"Its expression levels are reported to correlate with clinical parameters and patient outcomes, supporting its potential as a diagnostic and prognostic biomarker.\"}]","The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers | PDF",1789974911,35]