[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-326849-105":59,"doc-detail-326849-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-emerging-roles-of-ceacam6-in-human-cancer-review","The emerging roles of CEACAM6 in human cancer - Review","","Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a CEA-family cell adhesion protein that contributes to cancer biology. Research shows CEACAM6 is commonly upregulated in pancreatic, breast, non-small cell lung, gastric, and colon cancers and drives tumor progression, invasion, and metastasis. Its transcriptional expression is controlled by signaling axes, microRNAs, and DNA methylation, while N-glycosylation at Asn256 modulates protein function. CEACAM6 activation influences proliferation and therapy resistance through multiple downstream pathways, supporting its value as a diagnostic biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-emerging-roles-of-ceacam6-in-human-cancer-review/326849/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-emerging-roles-of-ceacam6-in-human-cancer-review/326849.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is CEACAM6 and why is it important in cancer?","Question",{"text":112,"@type":113},"CEACAM6 is a cell adhesion protein in the CEA family. It is generally upregulated in multiple cancers and promotes tumor progression, invasion, migration, and metastasis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which mechanisms regulate CEACAM6 expression and modification?",{"text":117,"@type":113},"CEACAM6 transcription is regulated by factors including the CD151/TGF-β1/Smad3 axis, specific microRNAs, and DNA methylation. The CEACAM6 protein also undergoes N-glycosylation at Asn256.",{"name":119,"@type":110,"acceptedAnswer":120},"How does CEACAM6 influence tumor signaling and therapy response?",{"text":121,"@type":113},"CEACAM6 can directly activate ERK1/2/MAPK or SRC/FAK/PI3K/AKT pathways, or act through EGFR, resulting in increased proliferation, invasion, migration, angiogenesis, and resistance to apoptosis and chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},326849,1790931278,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","INTERNATIONAL JOURNAL OF ONCOLOGY 64: 27, 2024  \nThe emerging roles ofCEACAM6 in human cancer (Review)  \nGUANHUA WU, DA WANG, FEI XIONG, QI WANG, WENZHENG LIU, JUNSHENG CHEN and YONGJUN CHEN  \nDepartment of Biliary‑Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P.R. China  \nReceived June 14, 2023; Accepted January 4, 2024  \nDOI: 10.3892/ijo.2024.5615  \nAbstract. Carcinoembryonic antigen (CEA)‑related cell adhesion molecule 6 (CEACAM6) is a cell adhesion protein of the CEA family of glycosyl phosphatidyl inositol anchored cell surface glycoproteins. A wealth of research has demonstrated that CEACAM6 is generally upregulated in pancreatic adeno‑ carcinoma, breast cancer, non‑small cell lung cancer, gastric cancer, colon cancer and other cancers and promotes tumor progression, invasionandmetastasis.Thetranscriptionalexpres‑ sion ofCEACAM6 is regulated by various factors, includingthe CD151/TGF‑β1/Smad3 axis, microRNA (miR)‑146, miR‑26a, miR‑29a/b/c, miR‑128, miR‑1256 and DNA methylation. In addition, theN‑glycosylation ofCEACAM6 protein atAsn256 is mediated by α‑1,6‑mannosylglycoptotein 6‑β‑N‑acetylglucos‑ aminyltransferase. In terms of downstream signaling path‑ ways, CEACAM6 promotes tumor proliferation by increasing  \nCorrespondence to: Professor Yongjun Chen, Department of Biliary‑Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, Hubei 430074, P.R. China  \nE‑[mail: yjchen@tjh.tjmu.edu.cn](mail: yjchen@tjh.tjmu.edu.cn)  \nAbbreviations: CEACAM6, carcinoembryonic antigen‑related cell adhesion molecule 6; OSCC, oral squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma; LSCC, laryngeal squamous cell carcinoma; ALL, acute lymphoblastic leukemia; ccRCC, clear cell renal cell carcinoma; BCP‑ALL, B‑cell precursor ALL; ELISA, enzyme‑linked immunosorbent assay; CEA, carcinoembryonic antigen; GPI, glycosyl phosphatidylinositol; DFS, disease‑free survival; OS, overall survival; EMT, epithelial‑to‑mesenchymal transition; IGF‑IR, IGF‑I receptor; IGF‑I, insulin‑like growth factor I; CRC, colorectal carcinoma; GBC, gallbladder cancer; MON, mucinous ovarian neoplasm; EGFR, epidermal growth factor receptor; ICAM‑1, intercellular adhesion molecule‑1; RT‑qPCR, reverse transcription‑quantitative polymerase chain reaction; LUAD, lung adenocarcinoma; Csk, C‑terminal Src kinase; FIT, fecal immunochemical test; CELTiC, the four genes CEACAM6, tetraspanin 8, galectin 4 and collagen type I α2 chain in combination; CagA, cytotoxin‑associated gene A; HopQ, Helicobacter pylori conserved outer membrane adhesin HopQ; UCB, urothelial carcinoma of the bladder; CAR‑T, chimeric antigen receptor T; pHLIP, pH low insertion peptide  \nKey words: CEACAM6, biomarker, cancer  \nlevels of cyclin D1 and cyclin‑dependent kinase 4 proteins. CEACAM6 can activate the ERK1/2/MAPK or SRC/focal adhesion kinase/PI3K/AKT pathways directly or through EGFR, leading to stimulation of tumor proliferation, invasion, migration, resistance to anoikis and chemotherapy, as well asangiogenesis. This article provides a review of the expression pattern, biological function and relationship with prognosis of CEACAM6 in cancer. In summary, CEACAM6 may be a valuable diagnostic biomarker and potential therapeutic target for human cancers exhibiting overexpression of CEACAM6 .  \nContents  \n1. Introduction  \n2. Overview of CEACAM6  \n3. Role of CEACAM6 in cancer  \n4. Molecular therapy of targeting CEACAM6  \n5. Conclusions  \n1. Introduction  \nCarcinoembryonic antigen (CEA)‑related cell adhesion mole‑ cules (CEACAMs) have 12 members with diverse functions and biological processes, such as cell adhesion, intracellular and intercellular signaling and shaping of tissue architec‑ ture (1,2) . All members are highly glycosylated proteins and typically consist of one variable (V)‑like Ig domain, known as the N domain, except fo","cbCaimoZ6SPbRZfI","https://ap.wps.com/l/cbCaimoZ6SPbRZfI","pdf",920477,15,"English","# Contents\n## 1. Introduction\n## 2. Overview of CEACAM6\n## 3. Role of CEACAM6 in cancer\n## 4. Molecular therapy of targeting CEACAM6\n## 5. Conclusions","[{\"question\":\"What is CEACAM6 and why is it important in cancer?\",\"answer\":\"CEACAM6 is a cell adhesion protein in the CEA family. It is generally upregulated in multiple cancers and promotes tumor progression, invasion, migration, and metastasis.\"},{\"question\":\"Which mechanisms regulate CEACAM6 expression and modification?\",\"answer\":\"CEACAM6 transcription is regulated by factors including the CD151/TGF-β1/Smad3 axis, specific microRNAs, and DNA methylation. The CEACAM6 protein also undergoes N-glycosylation at Asn256.\"},{\"question\":\"How does CEACAM6 influence tumor signaling and therapy response?\",\"answer\":\"CEACAM6 can directly activate ERK1/2/MAPK or SRC/FAK/PI3K/AKT pathways, or act through EGFR, resulting in increased proliferation, invasion, migration, angiogenesis, and resistance to apoptosis and chemotherapy.\"}]","The emerging roles of CEACAM6 in human cancer - Review | PDF",1789975541,38]