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IGF2BP2 functions as an m6A methylation reader and regulates RNA post-transcriptionally through recognition of m6A sites. It contributes to tumor initiation and progression and is closely linked to drug resistance. This review synthesizes mechanisms connecting IGF2BP2 to therapy resistance and highlights directions for more effective treatments.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-emerging-role-of-igf2bp2-in-cancer-therapy-resistance-from-molecular-mechanism-to-future-potential/343818/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-emerging-role-of-igf2bp2-in-cancer-therapy-resistance-from-molecular-mechanism-to-future-potential/343818.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is tumor therapy resistance a major problem in cancer treatment?","Question",{"text":112,"@type":113},"Tumor resistance is a primary reason for cancer treatment failure, significantly limiting available options and reducing therapy efficacy. 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The Emerging Role of IGF2BP2 in Cancer Therapy Resistance: From Molecular Mechanism to Future Potential. Int. J. Mol. Sci. 2024, 25, 12150. [https://](https://)[ ](https://)[doi.org/10.3390/ijms252212150](doi.org/10.3390/ijms252212150)  \nAcademic Editor: Alfonso Baldi  \nReceived: 17 October 2024  \nRevised: 4 November 2024  \nAccepted: 6 November 2024  \nPublished: 12 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nAbstract: Tumor resistance is one of the primary reasons for cancer treatment failure, significantly limiting the options and efficacy of cancer therapies. Therefore, overcoming resistance has become a critical factor in improving cancer treatment outcomes. IGF2BP2, as a reader of m6A methylation, plays a pivotal role in the post-transcriptional regulation of RNA through the methylation of m6A sites. It not only contributes to cancer initiation and progression but also plays a key role in tumor drug resistance. This review provides a comprehensive summary of the mechanisms by which IGF2BP2 contributes to therapy resistance, with the aim of improving the efficacy of chemotherapy in cancer treatment. Advancing research in this area is crucial for developing more effective therapies that could significantly improve the quality of life for cancer patients.  \nKeywords: IGF2BP2; drug resistance; m6A modification; RNA modifications; cancer  \n1. Introduction  \nCancer is considered a leading cause of death worldwide, claiming nearly 10 million lives in 2020, or approximately one in six deaths. According to the World Health Organization, cancer is a general term that includes a wide range of diseases that can affect any part of the body [1] . RNA modification is a post-transcriptional regulatory mechanism that is widely distributed across various types of RNA, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), small non-coding RNA, and long noncoding RNA (lncRNA) [2] . Recently, RNA modifications, novel hotspot areas of epigenetic research, have been shown to play crucial roles in protumor and anti-tumor immunity [3] . There are over 170 types of RNA modifications, including N6-methyladenosine (m6A), N6,2′ -O-dimethyladenosine (m6Am), 5-methylcytidine (m5C), 5-hydroxylmethylcytidine (hm5 C), and N1-methyladenosine (m1A) . Among these, m6A met","cbCaij0ZGcCygBbm","https://ap.wps.com/l/cbCaij0ZGcCygBbm","pdf",2130269,25,"English","# Introduction\n## RNA modifications and m6A methylation\n# IGF2BP2 as an m6A reader\n## Role in post-transcriptional regulation\n# IGF2BP2 and cancer therapy resistance\n## Chemotherapy efficacy implications\n# Future potential and research directions","[{\"question\":\"Why is tumor therapy resistance a major problem in cancer treatment?\",\"answer\":\"Tumor resistance is a primary reason for cancer treatment failure, significantly limiting available options and reducing therapy efficacy. Overcoming resistance is therefore critical to improving treatment outcomes.\"},{\"question\":\"What role does IGF2BP2 play in RNA regulation?\",\"answer\":\"IGF2BP2 acts as a reader of m6A methylation and regulates RNA post-transcriptionally by recognizing m6A sites. This function links IGF2BP2 to RNA modification-driven cellular effects.\"},{\"question\":\"How does IGF2BP2 relate to cancer drug resistance?\",\"answer\":\"IGF2BP2 contributes to tumor initiation and progression and plays a key role in tumor drug resistance. The review focuses on mechanisms connecting IGF2BP2 to therapy resistance.\"}]","The Emerging Role of IGF2BP2 in Cancer Therapy Resistance - From Molecular Mechanism to Future Potential | PDF",1790052246,63]