[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331388-105":59,"doc-detail-331388-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-emerging-role-of-carm1-in-cancer-review","The emerging role of CARM1 in cancer - Review","","Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes arginine methylation of histone and non-histone proteins and is crucial for the development of multiple cancers. Initially described as a transcriptional coregulator, CARM1 coordinates chromatin remodeling, transcription regulation, and mRNA splicing and stability. Through methylation-dependent control, CARM1 modulates cell cycle progression, metabolism, autophagy, redox homeostasis, and inflammation, thereby promoting tumorigenesis, metastasis, and therapeutic resistance. The review evaluates CARM1 as a therapeutic target and potential biomarker and discusses CARM1-targeting pharmaceutical strategies across cancer types.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-emerging-role-of-carm1-in-cancer-review/331388/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-emerging-role-of-carm1-in-cancer-review/331388.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-13","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does CARM1 play in cancer development?","Question",{"text":112,"@type":113},"CARM1 promotes cancer development by catalyzing arginine methylation of histone and non-histone proteins, influencing processes linked to tumorigenesis, metastasis, and therapeutic resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is CARM1 function related to protein arginine methyltransferases (PRMTs)?",{"text":117,"@type":113},"CARM1 is a type I PRMT (PRMT4) capable of mono- and asymmetric dimethylation on arginine residues, with distinct substrate specificity compared with other PRMTs.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is CARM1 considered a potential therapeutic target or biomarker?",{"text":121,"@type":113},"The review indicates that manipulating CARM1-controlled physiological functions is essential for key cancer processes, making CARM1 a viable intervention target and a possible biomarker for medication response in specific cancer types.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331388,1790688227,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Cellular Oncology (2024) 47:1503–1522  \n[https://doi.org/10.1007/s13402-024-00943-9](https://doi.org/10.1007/s13402-024-00943-9)  \nREVIEW  \nThe emerging role ofCARM1 in cancer  \nZizhuo Xie1 · Yuan Tian1 · Xiaohan Guo1 · Na Xie1  \nAccepted: 23 March 2024 / Published online: 15 April 2024 © The Author(s) 2024  \nAbstract  \nCoactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell cycle, metabolism, autophagy, redox homeostasis, and inflammation. By manipulating these physiological functions, CARM1 becomes essential in critical processes such as tumorigenesis, metastasis, and therapeutic resistance. Consequently, it emerges as a viable target for therapeutic intervention and a possible biomarker for medication response in specific cancer types. This review provides a comprehensive exploration of the various physiological functions of CARM1 in the context of cancer. Furthermore, we discuss potential CARM1-targeting pharmaceutical interventions for cancer therapy.  \nKeywords CARM1 · Arginine methylation · Tumorigenesis · Therapeutic target · Biomarker  \n1 Introduction  \nProtein methylation modification is a common post-translational modification (PTM) closely related to cancer incidence and progression. This PTM is precisely controlled by protein methyltransferases (writers) and demethylases (erasers) . The enzyme that catalyzes the methylation modification ofarginine is called protein arginine methyltransferase (PRMT), which has nine members, namely PRMT1-9 . Using S-adenosylmethionine (AdoMet/SAM) as a methyl donor, PRMTs can catalyze monomethylation (Type III isoform: PRMT7), symmetric dimethylation (Type II isoforms: PRMT5, PRMT5), and asymmetric dimethylation (Type I isoforms: PRMT1-4, PRMT6, PRMT8) (Fig. 1) [1] . By changing the hydrophobicity, increasing the size of the side  \nZizhuo Xie, Yuan Tian and Xiaohan Guo contributed equally to this work.  \n􀀍 Na Xie [naxie@scu.edu.cn](naxie@scu.edu.cn)  \n1 West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China  \nchain, and reducing the hydrogen bond potential, arginine methylation generates a docking site for effector proteins (reader), which include plant homeodomain (PHD) zinc finger, Tudor domain and SH3 domain [2] . Therefore, protein methylation affects the stability, localization, activity, and interaction of substrate proteins, which participate in a vari  \nety of physiological and pathological processes [3, 4] .  \nPRMT4 also known as coactivator-associated arginine methyltransferase 1 (CARM1), belongs to the type IPRMTs. This enzyme exhibits the capability to monomethylate and asymmetrically methylate the guanosine-nitrosyl group of arginine residues in target proteins [5] . CARM1 is known for its distinctive substrate specificity, as it typically methylates substrates within a loosely defined proline/ glycine/methionine motif, distinguishing itself from other PRMTs that target glycine/arginine-rich motifs [6] . Thenon-overlapping functions of CARM1 and other PRMTs render CARM1 an appealing therapeutic target for various diseases. Several recent reviews have explored CARM1’s potential as a therapeutic target in cancers, shedding light on its role in the pathogenesis of various malignancies [3, 5] . In this review, our objective is to highlight the impact ofCARM1’s functional diversity in carcinogenesis, particularly h","cbCaipOHo1N2RWgo","https://ap.wps.com/l/cbCaipOHo1N2RWgo","pdf",6303738,"English","# Introduction\n## Protein methylation and PRMT family\n## CARM1 features and specificity","[{\"question\":\"What role does CARM1 play in cancer development?\",\"answer\":\"CARM1 promotes cancer development by catalyzing arginine methylation of histone and non-histone proteins, influencing processes linked to tumorigenesis, metastasis, and therapeutic resistance.\"},{\"question\":\"How is CARM1 function related to protein arginine methyltransferases (PRMTs)?\",\"answer\":\"CARM1 is a type I PRMT (PRMT4) capable of mono- and asymmetric dimethylation on arginine residues, with distinct substrate specificity compared with other PRMTs.\"},{\"question\":\"Why is CARM1 considered a potential therapeutic target or biomarker?\",\"answer\":\"The review indicates that manipulating CARM1-controlled physiological functions is essential for key cancer processes, making CARM1 a viable intervention target and a possible biomarker for medication response in specific cancer types.\"}]","The emerging role of CARM1 in cancer - Review | PDF",1789993092]