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Histopathology, adenoma counts, and ELISA-based inflammatory indices quantify intestinal inflammation and damage. 16S rRNA sequencing and targeted metabolomics characterize microbiota shifts and short-chain fatty acid metabolism, supported by network pharmacology and Western blot signaling pathway validation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-efficacy-and-mechanism-of-qinghua-jianpi-recipe-in-inhibiting-canceration-of-colorectal-adenoma-based-on-inflammatory-cancer-transformation/376566/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-efficacy-and-mechanism-of-qinghua-jianpi-recipe-in-inhibiting-canceration-of-colorectal-adenoma-based-on-inflammatory-cancer-transformation/376566.png","ImageObject",300,407,{"name":92,"@type":93},"MrHarris58","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does the study aim to investigate about Qinghua Jianpi Recipe?","Question",{"text":113,"@type":114},"It investigates how Qinghua Jianpi Recipe prevents colon polyp recurrence and inhibits the process of “inflammatory cancer transformation.” It also examines changes in intestinal flora structure and the intestinal inflammatory immune microenvironment in mice treated with the recipe.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were therapeutic effects evaluated in both patients and animal models?",{"text":118,"@type":114},"Clinical trials assessed therapeutic effects in inflammatory bowel disease patients. For mechanism and anti-transformation evaluation, an adenoma canceration mouse model was used, with histopathology and adenoma number/pathology scoring.",{"name":120,"@type":111,"acceptedAnswer":121},"Which experimental techniques were used to analyze inflammation, microbiota, and metabolism?",{"text":122,"@type":114},"Inflammatory indices in tissue were measured using ELISA. Intestinal flora was detected via 16S rRNA high-throughput sequencing, and short-chain fatty acid metabolism was analyzed using targeted metabolomics.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376566,1790309750,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687212988360,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Hindawi  \nJournal of Immunology Research Volume 2023, Article ID 4319551, 19 pages [https://doi.org/10.1155/2023/4319551](https://doi.org/10.1155/2023/4319551)  \nResearch Article  \nThe Efficacy and Mechanism of Qinghua Jianpi Recipe in Inhibiting Canceration of Colorectal Adenoma Based on Inflammatory Cancer Transformation  \nTing Liu , 1 Juping You, 1 Qingjian Gao, 1 Yufeng Zhang , 1 Wei Xu, 1 Desong Kong ,2 Li Chen,3 Bao Yuan , 1 and Haibing Hua 1  \n1Department of Gastroenterology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, 214400 Jiangsu Province, China  \n2Chinese Medicine Modernization and Big Data Research Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210022 Jiangsu Province, China  \n3Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing,  \n210023 Jiangsu Province, China  \nCorrespondence should be addressed to Bao Yuan; doctoryuan1985@gmail.com and Haibing Hua; [jyzy3288@163.com](jyzy3288@163.com)  \nReceived 16 July 2022; Revised 6 October 2022; Accepted 12 October 2022; Published 15 February 2023  \nAcademic Editor: Xiaojiaoyang Li  \nCopyright © 2023 Ting Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nObjective. This study is aimed at exploring the effect of Qinghua Jianpi Recipe on preventing colon polyp recurrence and inhibiting the progress of “inflammatory cancer transformation.” And another goal is to explore the changes of intestinal flora structure and intestinal inflammatory (immune) microenvironment of mice with colon polyps treated by Qinghua Jianpi Recipe and to clarify its mechanism. Methods. Clinical trials were conducted to confirm the therapeutic effect of Qinghua Jianpi Recipe on patients with inflammatory bowel disease. The inhibitory effect of Qinghua Jianpi Recipe on “inflammatory cancer transformation” of colon cancer was confirmed by an adenoma canceration mouse model. Histopathological examination was used to evaluate the effects of Qinghua Jianpi Recipe on intestinal inflammatory state, adenoma number, and pathological changes of adenoma model mice. The changes of inflammatory indexes in intestinal tissue were tested by ELISA. Intestinal flora was detected by 16S rRNA high-throughput sequencing. Short-chain fatty acid metabolism in the intestine was analyzed by targeted metabolomics. Network pharmacology analysis of possible mechanism of Qinghua Jianpi Recipe on colorectal cancer was performed. Western blot was used to detect the protein expression of the related signaling pathways. Results. Qinghua Jianpi Recipe can significantly improve intestinal inflammation status and function in patients withinflammatory bowel disease. Qinghua Jianpi Recipe could significantly improve the intestinal inflammatory activity and pathological damage of adenoma model mice and reduce the number of adenoma. Qinghua Jianpi Recipe significantly increased the levels of Peptostreptococcales_Tissierellales, NK4A214_group, Romboutsia, and other intestinal flora after intervention. Meanwhile, the treatment group of Qinghua Jianpi Recipe could reverse the changes of short-chain fatty acids. Network pharmacology analysis and experimental studies showed that Qinghua Jianpi Recipe inhibited the “inflammatory cancer transformation” of colon cancer by regulating intestinal barrier function-related proteins, inflammatory and immunerelated signaling pathways, and free fatty acid receptor 2 (FFAR2) . Conclusion. Qinghua Jianpi Recipe can improve the intestinal inflammatory activity and pathological damage of patient and adenoma cancer model mice. And its mechanism is related to the regulation of intestinal flora structure and abundance, short-chain fatty a","cbCaidJELinkfL9W","https://ap.wps.com/l/cbCaidJELinkfL9W","pdf",3631309,"English","# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What does the study aim to investigate about Qinghua Jianpi Recipe?\",\"answer\":\"It investigates how Qinghua Jianpi Recipe prevents colon polyp recurrence and inhibits the process of “inflammatory cancer transformation.” It also examines changes in intestinal flora structure and the intestinal inflammatory immune microenvironment in mice treated with the recipe.\"},{\"question\":\"How were therapeutic effects evaluated in both patients and animal models?\",\"answer\":\"Clinical trials assessed therapeutic effects in inflammatory bowel disease patients. For mechanism and anti-transformation evaluation, an adenoma canceration mouse model was used, with histopathology and adenoma number/pathology scoring.\"},{\"question\":\"Which experimental techniques were used to analyze inflammation, microbiota, and metabolism?\",\"answer\":\"Inflammatory indices in tissue were measured using ELISA. Intestinal flora was detected via 16S rRNA high-throughput sequencing, and short-chain fatty acid metabolism was analyzed using targeted metabolomics.\"}]","The Efficacy and Mechanism of Qinghua Jianpi Recipe in Inhibiting Canceration of Colorectal Adenoma Based on Inflammatory Cancer Transformation | PDF",1790220007,48]