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This study evaluated the effectiveness and benefits of performing split-thickness skin grafting under topical anesthesia in diabetic patients. Data from 2018 to 2020 compared topical anesthesia with general/spinal anesthesia by wound healing, postoperative complications, and perioperative blood glucose patterns.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-effects-of-topical-anesthesia-on-outcomes-and-glucose-control-in-diabetic-patients-treated-with-split-thickness-skin-graft-surgery/436891/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-effects-of-topical-anesthesia-on-outcomes-and-glucose-control-in-diabetic-patients-treated-with-split-thickness-skin-graft-surgery/436891.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why might topical anesthesia be considered for diabetic patients undergoing split-thickness skin grafting?","Question",{"text":112,"@type":113},"Diabetic patients often have multiple comorbidities that increase the risks of adverse responses under general or spinal anesthesia, while topical anesthesia can help avoid those anesthesia-related risks.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients grouped in this study?",{"text":117,"@type":113},"Patients from 2018 to 2020 receiving split-thickness skin grafting for foot or leg wounds were categorized into two groups based on anesthesia method: topical anesthesia versus general/spinal anesthesia.",{"name":119,"@type":110,"acceptedAnswer":120},"What differences were reported between topical anesthesia and general/spinal anesthesia?",{"text":121,"@type":113},"The topical anesthesia group had fewer postoperative infections and required shorter postoperative hospitalization, and it showed lower mean blood glucose levels with less glucose variability, while complete wound healing at 4 weeks was similar between groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436891,1790739568,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","J Chin MedAssoc  \nOriginal article  \nThe effects of topical anesthesia on outcomes and glucose control in diabetic patients treated with split-thickness skin graft surgery  \nDun-Hao Changa,b,c, Shen-Che Lina,c, Yi-Ting Lina, Ke-Chung Changa, Chien-Lung Chanb,d,e*  \naDivision of Plastic and Aesthetic Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC; bDepartment of Information Management, Yuan Ze University, Taoyuan, Taiwan, ROC; cSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; dInnovation Center for Big Data and Digital Convergence(InnoBic), Yuan Ze University, Taoyuan, Taiwan, ROC; eZDT Group-Yuan Ze University Joint R&D Center for Big Data, Taoyuan, Taiwan, ROC  \nAbstract  \nBackground: Using split-thickness skin grafting to treat diabetic foot and leg ulcers is common. Diabetic patients usually exhibit multiple comorbidities and high risks of adverse responses to general and spinal anesthesia. Topical anesthesia can be an alternative to avoid these risks. In this study, the clinical experience of split-thickness skin grafting under topical anesthesia was demonstrated, to evaluate its effectiveness and benefits in diabetic patients.  \nMethods: From 2018 to 2020, diabetic patients with foot or leg wounds undergoing split-thickness skin grafting were reviewed and categorized into two groups according to the anesthesia methods: topical anesthesia and general/spinal anesthesia. Patient demographics, wound characteristics and healing status, postoperative complications, and perioperative blood glucose levels were recorded and analyzed.  \nResults: During the study period, 28 patients underwent split-thickness skin grafting under topical anesthesia and 46 under general/spinal anesthesia. The rate of complete wound healing in 4 weeks was similar in both the groups. The topical anesthesia group suffered fewer postoperative infections (3 .6% vs 21 .7%, p = 0.044), required shorter postoperative hospitalization (8 .3 ± 6.2 vs 11.1 ± 7.2 days, p = 0.048), and exhibited lower mean blood glucose levels and less glucose variability than the general/spinal anesthesia group.  \nConclusion: Conducting split-thickness skin grafting under topical anesthesia was shown to be a safe and effective means of treating leg and foot wounds in diabetic patients.  \nKeywords: Diabetic patients; Foot ulcers; Split-thickness skin graft; Topical anesthesia  \n1. INTRODUCTION  \nDiabetic foot wounds are complex and do not heal easily. They are the leading cause of hospitalization and limb amputations among diabetics. Timely healing and wound closure are critical to reducing the associated medical costs and morbidity.1 Nowadays, there are many available wound care products and synthetic biomaterials, but split-thickness skin grafting (STSG) remains the gold standard and is a first-line treatment for lower extremity wounds associated with diabetes.2  \nIn 2016, the Cochrane Review demonstrated skin grafting and tissue replacement to be a superior treatment for foot ulcers in people with diabetes.3 Another meta-analysis published in  \n*Address correspondence. Prof. Chien-Lung Chan, Department of Information Management, Yuan Ze University, 135, Yuan-Tung Road, Chung-Li, Taoyuan 320, Taiwan, [ROC. E-mail address: clchan@saturn.yzu.edu.tw](ROC. E-mail address: clchan@saturn.yzu.edu.tw) (C.-L. Chan)  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 306-312.  \nReceived May 28, 2022; accepted November 25, 2022.  \ndoi: 10. 1097/JCMA.0000000000000862.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \n2019 showed that skin grafts incr","cbCaic5nyAuLvpnt","https://ap.wps.com/l/cbCaic5nyAuLvpnt","pdf",692440,"English","# Introduction\n## Clinical context and rationale for topical anesthesia\n# Methods\n## Study design and patient grouping\n## Recorded variables and outcomes\n# Results\n## Wound healing outcomes\n## Postoperative infection and hospitalization\n## Perioperative blood glucose and variability\n# Conclusion","[{\"question\":\"Why might topical anesthesia be considered for diabetic patients undergoing split-thickness skin grafting?\",\"answer\":\"Diabetic patients often have multiple comorbidities that increase the risks of adverse responses under general or spinal anesthesia, while topical anesthesia can help avoid those anesthesia-related risks.\"},{\"question\":\"How were patients grouped in this study?\",\"answer\":\"Patients from 2018 to 2020 receiving split-thickness skin grafting for foot or leg wounds were categorized into two groups based on anesthesia method: topical anesthesia versus general/spinal anesthesia.\"},{\"question\":\"What differences were reported between topical anesthesia and general/spinal anesthesia?\",\"answer\":\"The topical anesthesia group had fewer postoperative infections and required shorter postoperative hospitalization, and it showed lower mean blood glucose levels with less glucose variability, while complete wound healing at 4 weeks was similar between groups.\"}]","The effects of topical anesthesia on outcomes and glucose control in diabetic patients treated with split-thickness skin graft surgery | PDF",1790679362,18]