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Photothermal therapy converts nanomaterial light energy into local heat to ablate tumor cells; photodynamic therapy generates cytotoxic reactive oxygen species via photosensitizers, light, and oxygen; radiotherapy damages tumor-cell DNA and triggers free-radical injury. 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Inhibiting Myc expression is linked to delaying cancer onset and progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do photothermal therapy, photodynamic therapy, and radiotherapy each work against tumors?",{"text":68,"@type":64},"Photothermal therapy uses nanomaterials to convert light into localized high temperatures that ablate tumor cells. Photodynamic therapy relies on photosensitizers, light, and oxygen to produce cytotoxic reactive oxygen species. Radiotherapy uses high-energy rays to induce DNA double-strand damage and free-radical injury in tumor cells.",{"name":70,"@type":61,"acceptedAnswer":71},"What categories of Myc inhibitors are described in the document?",{"text":72,"@type":64},"The document groups Myc inhibitors into strategies that block Myc transcription (e.g., BET inhibitors, G-quadruplex stabilizers), impair Myc translation (e.g., antisense oligonucleotides), and inhibit Myc dimerization and DNA binding using small molecules.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},371901,1790811326,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","International Journal of Nanomedicine  \n Open Access Full Text Article  \nREVIEW  \nThe Effect of Myc Inhibition Combined with the Synergistic Effect of Photothermal, Photodynamic and Radiotherapy in Tumor Treatment  \nYingwen Cui 1 , *, Wanhong Yang 1 , 2 , *, Wuyan Liu 1 , 3 , Yiling Li 1 , 3 , Chunbo Yu 1 , 3 , Changyan Yu 1 , 3 , Yun Liu 1–3 , Dawei Xu4 , Xinting Zhu 1 , 3  \n1Guizhou Provincial College-Based Key Laboratory for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2School of Forensic Medicine, Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3College of Basic Medicine, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 4CAS Key Laboratory for Biological Effects of  \nNanomaterials and Nanosafety National Center, Nanoscience and Technology Chinese Academy of Sciences, Beijing, 100190, People’s Republic of China *These authors contributed equally to this work  \nCorrespondence: Yun Liu; Xinting Zhu, Email [liuyunzmu@126.com](liuyunzmu@126.com); [Xintingzhu@126.com](Xintingzhu@126.com)  \n\n| Abstract: Photothermal therapy, photodynamic therapy, and radiotherapy offer the potential for precise tumor ablation with minimal adverse reactions. Myc is an oncogene that plays a critical role in cell growth and tumor development by regulating processes such as cell proliferation, differentiation, apoptosis, and metabolism. It is widely expressed in human cancers and is recognized as one of the potential targets for cancer therapy. Recent studies on the mechanism of Myc suggest that inhibiting its expression can delay cancer onset and progression. With the development of medical technology, photothermal therapy utilizes the photothermal conversion properties of nanomaterials to transform light energy into local high temperatures, thereby ablating tumor cells; photodynamic therapy relies on the synergistic action of photosensitizers, light, and oxygen to generate cytotoxic reactive oxygen species that destroy the structure of tumor cells; radiotherapy uses high-energy rays to precisely damage the DNA double-strands of tumor cells and induce free radical damage. All three therapies have demonstrated unique advantages and remarkable efficacy in the field of cancer treatment, offering new treatment options and survival hopes for cancer patients. Meanwhile, they have also propelled the continuous advancement of cancer treatment from traditional models towards more precise and minimally invasive approaches. In this review, we summarize the principles of photothermal, photodynamic therapy and radiotherapy and their related roles in tumor treatment with Myc inhibitors. We hope this review will provide new sights into cancer treatment related to the Myc gene.\u003Cbr>Keywords: photothermal therapy, photodynamic therapy, radiotherapy, Myc, Myc inhibitor, combination therapy |\n| --- |\n| Introduction\u003Cbr>The Myc gene is one of the most studied proto-oncogenes, and is associated with the formation, maintenance and progression of various cancers.1–3 More importantly, Myc is highly expressed in human cancers, and the research into its expression and function could bring new opportunities for tumor treatment. The Myc oncogene family consists of MYC, MYCN, and MYCL, all of which are major drivers of human tumorigenesis. Dysregulation of any member’s expression can lead to different malignancies.4 Myc activation through bromodomain proteins may be inhibited by drug-like molecules, thereby suppressing tumorigenesis.5 The inhibition of c-Myc expression by small hairpin RNA or bromodomain can achieve inhibition of leukemia initiating cell activity which has been validated in mouse leukemia model.6 Therefore, Myc has shifted from being considered “undruggable” to an “attractive” target for cancer therapy. However, the complex protein structure of Myc still poses a significant challenge for the development and optimization of Myc inhib","cbCaiqgmz6LjtIk6","https://ap.wps.com/l/cbCaiqgmz6LjtIk6","pdf",6236975,18,"English","# Introduction\n## Myc as an oncogene\n## Strategies to target Myc inhibitors\n# Abstract\n## Core rationale for combination approaches","[{\"question\":\"Why is Myc considered an important target in tumor treatment?\",\"answer\":\"Myc is a proto-oncogene highly expressed in many human cancers and regulates key processes such as cell growth and metabolism. Inhibiting Myc expression is linked to delaying cancer onset and progression.\"},{\"question\":\"How do photothermal therapy, photodynamic therapy, and radiotherapy each work against tumors?\",\"answer\":\"Photothermal therapy uses nanomaterials to convert light into localized high temperatures that ablate tumor cells. Photodynamic therapy relies on photosensitizers, light, and oxygen to produce cytotoxic reactive oxygen species. Radiotherapy uses high-energy rays to induce DNA double-strand damage and free-radical injury in tumor cells.\"},{\"question\":\"What categories of Myc inhibitors are described in the document?\",\"answer\":\"The document groups Myc inhibitors into strategies that block Myc transcription (e.g., BET inhibitors, G-quadruplex stabilizers), impair Myc translation (e.g., antisense oligonucleotides), and inhibit Myc dimerization and DNA binding using small molecules.\"}]","The Effect of Myc Inhibition Combined with the Synergistic Effect of Photothermal, Photodynamic and Radiotherapy in Tumor Treatment - Review | PDF",1790193142,45]