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This study used an autologous randomized controlled trial (25 patients) to compare laser versus minocycline hydrochloride after treatment, analyzing 376 subgingival samples across nine time points within one month. Minocycline showed delayed yet stronger core-bacteria elimination and better clinical indicators over 4 weeks, with long-term weakening of microbial network connectivity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-dynamic-elimination-effect-of-local-adjuvant-therapy-on-the-periodontal-microbiota-research-article-periodontitis-clinical-trial/449416/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-dynamic-elimination-effect-of-local-adjuvant-therapy-on-the-periodontal-microbiota-research-article-periodontitis-clinical-trial/449416.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the objective of the study on local adjuvant therapy?","Question",{"text":112,"@type":113},"The study aimed to determine the additional clearance effect of local adjunctive therapy on the microbiota of periodontitis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the clinical trial designed and what treatments were compared?",{"text":117,"@type":113},"An autologous randomized controlled trial included 25 periodontitis patients, comparing laser versus minocycline hydrochloride administered after scaling and root planing, with multiple time-point sampling of subgingival sites.",{"name":119,"@type":110,"acceptedAnswer":120},"Which therapy showed better outcomes and what were the main findings?",{"text":121,"@type":113},"Minocycline hydrochloride outperformed semiconductor laser adjunctive therapy in eliminating periodontitis core bacteria, improving microbial community structure, and enhancing clinical indicators.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},449416,1790794513,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","JOURNAL OF ORAL MICROBIOLOGY 2026, VOL. 18, NO. 1, 2608421  \n[https://doi.org/10.1080/20002297.2025.2608421](https://doi.org/10.1080/20002297.2025.2608421)  \nRESEARCH ARTICLE     \nThe dynamic elimination effect of local adjuvant therapy on the periodontal microbiota  \nXiaoqing Lia,\\#, Xiaogang Shana,\\#, Lushuai Qianb, Hanyue Jiab, Huimin Fanc, Ziyi Baoa, Cheng Yua, Hui Zhaoa, Hongping Zhanga, Yanyan Zhenga and Jinfeng Wangc  \naThe Third Clinical Institute Affiliated to Wenzhou Medical University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, People's Republic of China; bSchool of Mechanical and Electrical Engineering, China Jiliang University, Hangzhou, People's Republic of China; cCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, People's Republic of China  \nABSTRACT  \nBackground: Implementing local adjunctive therapy during scaling and root planing has become increasingly crucial for optimizing the therapeutic efficacy of periodontitis and reshaping the periodontal microecological environment.  \nObjective: This study aimed to reveal the additional clearance effect of local adjunctive therapy on the microbiota of periodontitis.  \nDesign: An autologous randomized controlled trial included 25 periodontitis patients. After scaling and root planing, one oral side randomly received laser or minocycline, the other as control. Three hundred and seventy-six subgingival samples were collected at nine time points within 1 month for integrated analysis of microbiota and clinical indicators.  \nResults: Compared with laser adjunctive therapy, minocycline hydrochloride adjunctive therapy showed no difference in pathogen clearance rate within 6 h, but significant differences emerged in days 1, 3 and 7 (χ² test, P \u003C 0.05) . Meanwhile, within the 7-day period, the number of core bacteria of periodontitis with significant intergroup differences increased progressively over time (LDA > 2.0, P \u003C 0.05) . After 4 weeks, minocycline hydrochloride adjunctive therapy eliminated 12 more core bacteria of periodontitis than scaling and root planing alone, while significantly reduced the bleeding on probing (Wilcoxon test, p = 0.0085) and clinical attachment loss indicators (Wilcoxon test, p = 0.0456) . In the long term, minocycline hydrochloride adjunctive therapy weakened microbial network connectivity, strongly influencing bacterial interactions involving Leptotrichia, Dialister and Atopobium.  \nConclusions: Minocycline hydrochloride local adjunctive therapy outperforms semiconductor laser local adjunctive therapy in terms of eliminating periodontitis core bacteria, improving the microbial community structure, and enhancing clinical indicators.  \nARTICLE HISTORY  \nReceived 20 October 2025 Revised 10 December 2025 Accepted 18 December 2025  \nKEYWORDS  \nPeriodontitis; subgingival plaque; semiconductor laser adjunctive therapy; minocycline hydrochloride adjunctive therapy; core microbiota  \nIntroduction  \nIn 2021, over one billion people suffered from severe periodontitis, with a global age-standardised prevalence rate of 12.50% . By 2050, this is projected to rise 44.32% to 1.5 billion [ 1] . Untreated periodontitis severely harms oral health and quality of life, and may link to systemic diseases like diabetes, cardiovascular conditions and adverse pregnancy outcomes [2–4] .  \nMultifactorial oral infection driven by dental plaque microbiota are the main cause of periodontitis [5–7] . Socransky et al. grouped subgingival microorganisms into five complexes based on their link to periodontitis: the red complex, consisting of Tannerella, Porphyromonas and Treponema, which are  \nCONTACT Yanyan Zheng  [yying33171@163.com](yying33171@163.com)  The Third Clinical Institute Affiliated to Wenzhou Medical University/Wenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang, 325000, People's Republic of China; Jinfeng Wang  \n [wangjf@cau.edu.cn](wangjf@c","cbCaitdppzh2Bxbh","https://ap.wps.com/l/cbCaitdppzh2Bxbh","pdf",4564573,"English","# Abstract\n## Background\n## Objective\n## Design\n## Results\n## Conclusions\n# Introduction\n## Epidemiology and burden of periodontitis\n## Microbiota complexes and disease linkage\n## Scaling and root planing rationale","[{\"question\":\"What is the objective of the study on local adjuvant therapy?\",\"answer\":\"The study aimed to determine the additional clearance effect of local adjunctive therapy on the microbiota of periodontitis.\"},{\"question\":\"How was the clinical trial designed and what treatments were compared?\",\"answer\":\"An autologous randomized controlled trial included 25 periodontitis patients, comparing laser versus minocycline hydrochloride administered after scaling and root planing, with multiple time-point sampling of subgingival sites.\"},{\"question\":\"Which therapy showed better outcomes and what were the main findings?\",\"answer\":\"Minocycline hydrochloride outperformed semiconductor laser adjunctive therapy in eliminating periodontitis core bacteria, improving microbial community structure, and enhancing clinical indicators.\"}]","The dynamic elimination effect of local adjuvant therapy on the periodontal microbiota - Research article - periodontitis clinical trial | PDF",1790730170,48]