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Material and Methods: 1,468 women scheduled for FET were allocated into four progesterone-duration groups (3, 4, 5, or 6 days). Primary outcomes included clinical pregnancy rate, ongoing pregnancy rate, live birth rate, and miscarriage rate. Results: Rates of gestational sac, fetal heartbeat, ongoing pregnancy, live birth, and miscarriage were higher with 6 days versus other groups. Conclusion: Progesterone for six days before transfer significantly improves fertility outcomes in FET cycles.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-duration-of-progesterone-administration-determines-pregnancy-outcome-in-frozen-thawed-embryo-transfer-original-research/503553/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-duration-of-progesterone-administration-determines-pregnancy-outcome-in-frozen-thawed-embryo-transfer-original-research/503553.png","ImageObject",300,407,{"name":92,"@type":93},"anakgang17","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-10-03",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"What additional factors were associated with higher live birth rates?","Question",{"text":112,"@type":113},"Lower number of transfers, lower 3rd day P4 values, higher CZP day P4 values, and higher cycle days during transfer were associated with higher live birth rates.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},503553,1791351125,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":52},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Annals of Clinical and Analytical Medicine  \nOriginal Research  \nThe duration of progesterone administration determines pregnancy outcome in frozen-thawed embryo transfer  \nProgesterone in FET cycles  \nRamazan Ozyurt1, Arzu Yurci2, Nurettin Turktekin3, Aret Kamar1, Bertan Demir4  \n1 Istanbul In Vitro Fertilization (IVF) Center, Istanbul  \n2 IVF Unit Center, Memorial Kayseri Hospital, Kayseri  \n3 Department of Operating Room Services, Nisantasi University, Vocational School, Istanbul  \n4 Department of Obstetrics and Gynecology, Kayseri City Training and Research Hospital, Kayseri, Turkey  \nAbstract  \nAim: In this study, we aimed to compare the effects of different progesterone treatment durations on pregnancy outcomes in patients undergoing frozenthawed embryo transfer (FET).  \nMaterial and Methods: A total of 1468 patients who were scheduled for frozen-thawed embryo transfer were included in the study. The patients were divided into four groups according to the duration of progesterone administration. The patients in the first group received progesterone treatment for 3 days, the patients in the second group for 4 days, the patients in the third group for 5 days and the patients in the fourth group for 6 days, followed by FET. The primary outcome measure of our study was to evaluate clinical pregnancy rate, ongoing pregnancy rate, live birth rate and miscarriage rate per pregnancy.  \nResults: The frequencies of gestational sac, fetal heartbeat, ongoing pregnancy, live birth and miscarriage rates were significantly higher in the patients who were given progesterone for 6 days than in other groups (p \u003C0.001, for each). In a multivariate analysis, we found that 5-day embryos have 1.6-fold higher live birth rates than day 3 embryos (OR: 1. 677, 95%CI: 1.328-2. 117, p\u003C0.001). In addition, we found that lower numbers of transfer (p=0.008), lower 3rd day P4 values (p=0.001), higher CZP day P4 values (p\u003C0.001) and higher cycle days during transfer (p\u003C0.001) are associated with higher live birth rates Discussion: In FET cycles, giving progesterone for six days before transfer significantly increases the fertility outcome compared to 3,4 or 5 days of progesterone treatment.  \nKeywords  \nFrozen-Thawed, IVF, Pregnancy Rate, Live Birth, Progesterone  \nDOI: 10.4328/ACAM.21099 Received: 2022-02-06 Accepted: 2022-09-12 Published Online: 2022-09-21 Corresponding Author: Ramazan Ozyurt, Istanbul In Vitro Fertilization (IVF) Center, Istanbul, Turkey.  \nE-mail: [atasagun02@hotmail.com](atasagun02@hotmail.com) P: +90 532 748 34 90  \nCorresponding Author ORCID ID: [https://orcid.org/0000-0001-6822-2222](https://orcid.org/0000-0001-6822-2222)  \nAnnals of Clinical and Analytical Medicine 1  \nIntroduction  \nWhile planning in vitro fertilization (IVF), the embryo may need to be frozen due to various causes. Collected oocytes can be frozen and stored under appropriate conditions until embryo transfer is performed with thawed embryos in later cycles given that required characteristics or conditions are met [1,2]. Finding the best time for implantation in frozen embryo transfer is crucial for successful clinical outcomes. There are various approaches that enable synchronization of the frozen embryo day and endometrium development. The transfer process can be performed by ensuring that the most suitable time of the endometrium for implantation is synchronized with the frozen embryo day by closely monitoring the endometrium, or by utilizing interventions that prepare the endometrium from the first day of menstruation [3]. However, to date, there has been no consensus on the optimal duration of progesterone use for endometrium preparation in frozen embryo transfer [4,5]. This study was planned to compare the effects of different progesterone treatment durations on pregnancy outcomes inpatients undergoing frozen-thawed embryo transfer (FET).  \nMaterial and Methods  \nThis retrospective cohort study was performed among patients admitted to the Memorial Kayseri ","cbCailJ5gOVAowLV","https://ap.wps.com/l/cbCailJ5gOVAowLV","pdf",194640,"English","# Abstract\n# Introduction\n# Material and Methods\n## Statistical Analysis","[{\"question\":\"What additional factors were associated with higher live birth rates?\",\"answer\":\"Lower number of transfers, lower 3rd day P4 values, higher CZP day P4 values, and higher cycle days during transfer were associated with higher live birth rates.\"}]","The duration of progesterone administration determines pregnancy outcome in frozen-thawed embryo transfer - Original Research | PDF",1791057983]