[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330668-105":59,"doc-detail-330668-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-double-life-of-a-chemotherapy-drug-immunomodulatory-functions-of-gemcitabine-in-cancer","The double life of a chemotherapy drug - Immunomodulatory functions of gemcitabine in cancer","","Although immunotherapies have transformed the management of several cancers, many tumor types still fail to respond and are treated largely with chemotherapy. Yet chemotherapeutic agents can become ineffective as resistance develops. Evidence suggests that some chemotherapies act as immune-modifying drugs rather than purely cytotoxic agents. Gemcitabine, widely used across multiple cancers and studied for immune-editing properties, is reviewed for its effects on immune cells and proteins and its potential as a priming partner to improve immunotherapy efficacy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-double-life-of-a-chemotherapy-drug-immunomodulatory-functions-of-gemcitabine-in-cancer/330668/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-double-life-of-a-chemotherapy-drug-immunomodulatory-functions-of-gemcitabine-in-cancer/330668.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are many cancer types still not responsive to immunotherapies?","Question",{"text":112,"@type":113},"Many cancers remain insensitive due to factors such as insufficient mutational burden, inhibitory immune checkpoint expression patterns, and defects in antigen presentation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What additional roles can chemotherapy drugs play beyond cytotoxicity?",{"text":117,"@type":113},"Some chemotherapies function as immune-modifying agents, capable of suppressing or invigorating immune responses rather than only killing cancer cells.",{"name":119,"@type":110,"acceptedAnswer":120},"How does gemcitabine relate to immunotherapy strategies?",{"text":121,"@type":113},"Gemcitabine is discussed as a chemotherapy drug with immunomodulatory abilities that may work as a priming agent to enhance immunotherapy efficacy, especially in cancers that are otherwise unresponsive.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330668,1790167259,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","DOI: 10. 1002/cam4 .7287  \nREVIEW  \nThe double life of a chemotherapy drug:  \nImmunomodulatory functions of gemcitabine in cancer  \nAlaina C. Larson1,2 | Kenadie R. Doty1,2 | Joyce C. Solheim1,2,3,4   \n1Eppley Institute for Research in Cancer & Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA  \n2Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA  \n3Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA  \n4Department of Pathology, Microbiology, & Immunology,  \nUniversity of Nebraska Medical Center, Omaha, Nebraska, USA  \nCorrespondence  \nJoyce C. Solheim, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198, USA. [Email:](Email: jsolheim@unmc.edu)[ jsolheim@unmc.edu](Email: jsolheim@unmc.edu)  \nFunding information  \nNational Cancer Institute, Grant/ Award Number: P30CA036727 and T32CA009476; American Association of Immunologists  \n1 | INTRODUCTION  \nAbstract  \nAlthough the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune-based treatment and are largely managed by chemotherapy drugs. However, chemotherapeutics are not infallible and are frequently rendered ineffective as resistance develops from prolonged exposure. Recent investigations have indicated that some chemotherapy drugs have additional functions beyond their normative cytotoxic capacity and are in fact immune-modifying agents. Of the pharmaceuticals with identified immune-editing properties, gemcitabine is well-studied and of interest to clinicians and scientists alike. Gemcitabine is a chemotherapy drug approved for the treatment of multiple cancers, including breast, lung, pancreatic, and ovarian. Because of its broad applications, relatively low toxicity profile, and history as a favorable combinatory partner, thereis promise in the recharacterization of gemcitabine in the context of the immune system. Such efforts may allow the identification of suitable immunotherapeutic combinations, wherein gemcitabine can be used as a priming agent to improve immunotherapy efficacy in traditionally insensitive cancers. This review looks to highlight documented immunomodulatory abilities of one of the most wellknown chemotherapy agents, gemcitabine, relating to its influence on cells and proteins of the immune system.  \nKEYWORDS  \ncancer biology, chemotherapy, immunology, pancreatic cancer  \nthose individuals who succumb to cancer.1 The reality of this insufficiency prompted the development of therapies  \nThe immune system is a network comprised of cells, proteins, tissues, and organs which function to protect the host from foreign pathogens and tumor development. Although the immune system has intrinsic anticancer properties, it is not infallible and notably liable for failure in the case of  \nto reinvigorate immune reactivity, aptly called immunotherapies, and includes the likes of vaccines, cytokines, adoptive T-cell transfer, and monoclonal antibodies (e.g., immune checkpoint inhibitors) .2 The scope of these immunotherapies, much like the components of the immune  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.  \nCancer Medicine. 2024;13:e7287 .  \n[https://doi.org/10.1002/cam4.7287](https://doi.org/10.1002/cam4.7287)  \n[wileyonlinelibrary.com/journal/cam4](wileyonlinelibrary.com/journal/cam4)  \n1 of 17  \nsystem itself, is widespread and encompasses agents that both invoke and inhibit the immune response as modes of therapeutic management.3–6 Immunotherapies, particularly immune checkpoint inhibitors, have revolutionized treatment and patient","cbCaie7EJliHcBWH","https://ap.wps.com/l/cbCaie7EJliHcBWH","pdf",3213652,17,"English","# Introduction\n## Abstract\n## Keywords","[{\"question\":\"Why are many cancer types still not responsive to immunotherapies?\",\"answer\":\"Many cancers remain insensitive due to factors such as insufficient mutational burden, inhibitory immune checkpoint expression patterns, and defects in antigen presentation.\"},{\"question\":\"What additional roles can chemotherapy drugs play beyond cytotoxicity?\",\"answer\":\"Some chemotherapies function as immune-modifying agents, capable of suppressing or invigorating immune responses rather than only killing cancer cells.\"},{\"question\":\"How does gemcitabine relate to immunotherapy strategies?\",\"answer\":\"Gemcitabine is discussed as a chemotherapy drug with immunomodulatory abilities that may work as a priming agent to enhance immunotherapy efficacy, especially in cancers that are otherwise unresponsive.\"}]","The double life of a chemotherapy drug - Immunomodulatory functions of gemcitabine in cancer | PDF",1789989683,43]