[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338366-105":59,"doc-detail-338366-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-development-of-the-occurrence-and-metastasis-of-breast-cancer-by-single-cell-sequencing","The development of the occurrence and metastasis of breast cancer by single-cell sequencing","","Breast cancer is the most common malignant tumor among women worldwide and a leading cause of cancer death. Although early-stage 5-year survival exceeds 90%, advanced disease still shows medication resistance, driving poor prognosis, high recurrence, and low survival. Single-cell sequencing (SCS) compares gene structure and expression across individual cells to uncover molecular subgroups, mechanisms, and disease development. This review outlines SCS fundamentals and summarizes research applying SCS to breast cancer occurrence and metastasis to support more comprehensive treatment ideas.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-development-of-the-occurrence-and-metastasis-of-breast-cancer-by-single-cell-sequencing/338366/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-development-of-the-occurrence-and-metastasis-of-breast-cancer-by-single-cell-sequencing/338366.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is single-cell sequencing important in breast cancer research?","Question",{"text":113,"@type":114},"Single-cell sequencing analyzes gene expression and structure at the level of individual cells, enabling discovery of unusual molecular subgroups and mechanisms that bulk sequencing cannot resolve.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What limitations in breast cancer treatment motivate this research?",{"text":118,"@type":114},"Advanced breast cancer often develops medication resistance, leading to poor prognosis, high recurrence, and low survival rates despite improved early-stage outcomes.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the review position single-cell sequencing for comprehensive therapy?",{"text":122,"@type":114},"It summarizes current studies on SCS in breast cancer occurrence and metastasis, aiming to provide fresh ideas that support more comprehensive treatment approaches.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},338366,1790797162,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Chen et al. Cancer Cell International (2024) 24:349  \n[https://doi.org/10.1186/s12935-024-03531-x](https://doi.org/10.1186/s12935-024-03531-x)  \nCancer Cell International  \nREVIEW Open Access  \nThe development of the occurrence and metastasis of breast cancer by single-cell sequencing  \nMan Chen2†, Mengya Feng 1†, Hai Lei 1, Dan Mo 1*, Shengnan Ren2* and Dechun Yang2*  \nAbstract  \nBreast cancer is currently the most frequent malignant tumor and the leading cause of cancer death among women globally. Although the five-year survival rate for early breast cancer has risen to more than 90%, medication resistance persists in advanced breast cancer and some intractable breast cancer, resulting in a poor prognosis, a high recurrence rate, and a low survival rate. Single-cell sequencing (SCS) is the study of a single cell’s gene structure and expression level differences in order to discover unusual molecular subgroups, disease development, and a variety of mechanisms. This review briefly discusses single-cell sequencing and its application, and lists the research on single-cell sequencing in the development and metastasis of breast cancer, in order to bring fresh ideas for the comprehensive treatment of breast cancer.  \nKeywords Breast cancer, Single-cell sequencing, Tumor occurrence, Tumor metastasis  \nIntroduction  \nSince the mid-2000s, 31% of all malignancies in women have been related to breast cancer [1]. The World Health Organization estimates that there are 107.8 million malignant tumors in women worldwide, 19.6 million of which are related to breast cancer [2]. Although it has decreased from the previous year, there were still 685,00 deaths in 2020 from breast cancer, and the detection and treatment  \n†Man Chen and Mengya Feng contributed equally to this work.  \n*Correspondence: Dan Mo [646324947@qq.com](646324947@qq.com)[ ](646324947@qq.com)Shengnan Ren [ShengnanRen@jlu.edu.cn](ShengnanRen@jlu.edu.cn)[ ](ShengnanRen@jlu.edu.cn)Dechun Yang [ydchun2021@163.com](ydchun2021@163.com)  \n1Department of Breast Surgery, The People’s Hospital of Chuxiong Yi Autonomous Prefecture, No. 318 Lucheng South Road, Chuxiong, Yunnan, China  \n2Department of Breast Surgery, Caner Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming, China  \nof the disease continue to provide significant obstacles. From 2011 to 2020, approximately 138 persons per 100,000 were diagnosed with the disease, and its fatality rate is approximately 1%[3, 4]. Currently, the majority of breast cancer research is focused on bulk cell sequencing, which cannot accurately analyze the distinctions between individual cells. The distinctions between individual cells cannot be precisely explored. Single-cell sequencing is the study of transcriptomics, genomics, metabolomics, and proteomics at the level of a single cell. It reveals the structure and expression level of genes in individual cells by amplifying the whole genome and transcriptome of individual cells, followed by high-throughput sequencing [5]. The use of single-cell sequencing technology in breast cancer research is more beneficial in terms of providing rapid and accurate tailored treatment to patients and overcoming the challenge of drug resistance in breast cancer. This review briefly explains single-cell sequencing and its applications, as well as a list of studies on singlecell sequencing in the development and metastasis of  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The i","cbCait6wldh9Gla5","https://ap.wps.com/l/cbCait6wldh9Gla5","pdf",1829628,"English","# Abstract\n# Introduction\n# Single-cell sequencing technology (SCS)\n## Transcriptomics (SC-RNA seq)","[{\"question\":\"Why is single-cell sequencing important in breast cancer research?\",\"answer\":\"Single-cell sequencing analyzes gene expression and structure at the level of individual cells, enabling discovery of unusual molecular subgroups and mechanisms that bulk sequencing cannot resolve.\"},{\"question\":\"What limitations in breast cancer treatment motivate this research?\",\"answer\":\"Advanced breast cancer often develops medication resistance, leading to poor prognosis, high recurrence, and low survival rates despite improved early-stage outcomes.\"},{\"question\":\"How does the review position single-cell sequencing for comprehensive therapy?\",\"answer\":\"It summarizes current studies on SCS in breast cancer occurrence and metastasis, aiming to provide fresh ideas that support more comprehensive treatment approaches.\"}]","The development of the occurrence and metastasis of breast cancer by single-cell sequencing | PDF",1790023277]