[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383435-105":59,"doc-detail-383435-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-current-understanding-of-the-immune-landscape-relative-to-radiotherapy-across-tumor-types","The current understanding of the immune landscape relative to radiotherapy across tumor types","","Radiotherapy is a standard cancer therapy that directly affects tumor cells and the surrounding milieu, simultaneously priming and potentially restricting antitumor immunity. This review explains how a heterogeneous immune tumor microenvironment and systemic immunity—collectively termed the immune landscape—shape response dynamics and complicate prediction. Common post-irradiation patterns include increased infiltrating T lymphocytes and PD-L1 upregulation, while lymphopenia and therapy-induced expansion of immunosuppressive populations such as M2 macrophages and MDSCs can hinder survival and efficacy. The article further emphasizes how treatment parameters themselves can be leveraged.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-current-understanding-of-the-immune-landscape-relative-to-radiotherapy-across-tumor-types/383435/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-current-understanding-of-the-immune-landscape-relative-to-radiotherapy-across-tumor-types/383435.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does the review describe as the immune landscape in relation to radiotherapy?","Question",{"text":113,"@type":114},"It defines the immune landscape as a heterogeneous network of immune cells and immune components, including factors such as chemoattractants and tumor mutational burden, which help determine how tumors respond to treatment.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What immune changes after radiation are highlighted as potentially beneficial?",{"text":118,"@type":114},"The review notes an upsurge in infiltrating T lymphocytes and increased PD-L1 expression, suggesting possible patient benefit when combined with immunotherapy.",{"name":120,"@type":111,"acceptedAnswer":121},"What obstacles to survival does the review associate with radiotherapy in “cold” tumors?",{"text":122,"@type":114},"It emphasizes lymphopenia within the tumor microenvironment of cold tumors or caused by radiation as an important obstacle to patient survival.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383435,1790436340,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","TYPE Review  \nPUBLISHED 16 March 2023  \nDOI 10.3389/fimmu.2023.1148692  \nOPEN ACCESS  \nEDITED BY  \nShaoli Song,  \nFudan University, China  \nREVIEWED BY Ana Vuletic´,  \nInstitute of Oncology and Radiology of Serbia, Serbia  \nEnde Zhao,  \nNew York University, United States  \n*CORRESPONDENCE Mohammad Krayem  \n [mohammad.krayem@hubruxelles.be](mohammad.krayem@hubruxelles.be)  \nSPECIALTY SECTION  \nThis article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology  \nRECEIVED 20 January 2023  \nACCEPTED 03 March 2023  \nPUBLISHED 16 March 2023  \nCITATION  \nIliadi C, Verset L, Bouchart C, Martinive P, Van Gestel D and Krayem M (2023) The current understanding of the immune landscape relative to radiotherapy across tumor types.  \nFront. Immunol. 14:1148692 .  \ndoi: 10.3389/fimmu.2023.1148692  \nCOPYRIGHT  \n© 2023 Iliadi, Verset, Bouchart, Martinive, Van Gestel and Krayem. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe current understanding of the immune landscape relative to radiotherapy across tumor types  \nChrysanthi Iliadi 1,2, Laurine Verset 3, Christelle Bouchart 1, Philippe Martinive 1, Dirk Van Gestel1  \nand Mohammad Krayem 1,2*  \n1 Department of Radiation Oncology, Institut Jules Bordet, Universite´ Libre de Bruxelles (ULB), Hˆopital Universitaire de Bruxelles (H. U. B), Brussels, Belgium, 2 Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Universite´ Libre de Bruxelles (ULB), Hˆopital Universitaire de Bruxelles (H. U. B), Brussels, Belgium, 3 Department of Pathology, Institut Jules Bordet, Universite´ Librede Bruxelles (ULB), Hˆopital Universitaire de Bruxelles (H. U. B), Brussels, Belgium  \nRadiotherapy is part of the standard of care treatment for a great majority of cancer patients. As a result of radiation, both tumor cells and the environment around them are affected directly by radiation, which mainly primes but also might limit the immune response. Multiple immune factors play a role in cancer progression and response to radiotherapy, including the immune tumor microenvironment and systemic immunity referred to as the immune landscape. A heterogeneous tumor microenvironment and the varying patient characteristics complicate the dynamic relationship between radiotherapy and this immune landscape. In this review, we will present the current overview of the immunological landscape in relation to radiotherapy in order to provide insight and encourage research to further improve cancer treatment. An investigation into the impact of radiation therapy on the immune landscape showed in several cancers a common pattern of immunological responses after radiation . Radiation leads to an upsurge in infiltrating T lymphocytes and the expression of programmed death ligand 1 (PD-L1) which can hint at a benefit for the patient when combined with immunotherapy. In spite of this, lymphopenia in the tumor microenvironment of ‘cold ’ tumors or caused by radiation is considered to be an important obstacle to the patient’s survival. In several cancers, a rise in the immunosuppressive populations is seen after radiation, mainly pro-tumoral M2 macrophages and myeloid-derived suppressor cells (MDSCs) . As a final point, we will highlight how the radiation parameters themselves can influence the immune system and, therefore, be exploited to the advantage of the patient.  \nKEYWORDS  \nradiotherapy, cancer, systemic immune response, immune tumor microenvironment, immune landscape, biomarker, immune cells  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nIntroduct","cbCaiceSfaGu4bu8","https://ap.wps.com/l/cbCaiceSfaGu4bu8","pdf",1152294,22,"English","# Introduction\n## Immune landscape and tumor microenvironment\n## Pan-cancer immune classifications","[{\"question\":\"What does the review describe as the immune landscape in relation to radiotherapy?\",\"answer\":\"It defines the immune landscape as a heterogeneous network of immune cells and immune components, including factors such as chemoattractants and tumor mutational burden, which help determine how tumors respond to treatment.\"},{\"question\":\"What immune changes after radiation are highlighted as potentially beneficial?\",\"answer\":\"The review notes an upsurge in infiltrating T lymphocytes and increased PD-L1 expression, suggesting possible patient benefit when combined with immunotherapy.\"},{\"question\":\"What obstacles to survival does the review associate with radiotherapy in “cold” tumors?\",\"answer\":\"It emphasizes lymphopenia within the tumor microenvironment of cold tumors or caused by radiation as an important obstacle to patient survival.\"}]","The current understanding of the immune landscape relative to radiotherapy across tumor types | PDF",1790257025,55]