[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-339445-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-339445-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-crucial-roles-of-diet-microbiota-and-postbiotics-in-colorectal-cancer-accepted-and-published-online-in-2024","The Crucial Roles of Diet, Microbiota, and Postbiotics in Colorectal Cancer - Accepted and Published Online in 2024","","Colorectal cancer ranks among the world’s most lethal cancers, with rising prevalence in recent years. After dysbiosis was identified in colorectal cancer, research shifted from probiotics toward non-living cells, components, and metabolites due to safety concerns in susceptible and immunocompromised patients and risks such as antibiotic resistance. This review evaluates evidence on how diet, gut microbiota, and postbiotics influence colorectal cancer, and outlines directions for future postbiotics research.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-crucial-roles-of-diet-microbiota-and-postbiotics-in-colorectal-cancer-accepted-and-published-online-in-2024/339445/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-crucial-roles-of-diet-microbiota-and-postbiotics-in-colorectal-cancer-accepted-and-published-online-in-2024/339445.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why has research moved from probiotics to postbiotics for colorectal cancer?","Question",{"text":63,"@type":64},"Probiotics raise safety concerns in susceptible and immunocompromised patients and may contribute to antibiotic resistance. The review discusses a shift toward non-living cells, their components, and metabolites, collectively captured by the postbiotic concept.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What does the review say about the relationship between diet, gut microbiota, and colorectal cancer?",{"text":68,"@type":64},"The link is established primarily as an association rather than a clear cause-effect relationship. Gut microbiota can transform gastrointestinal and dietary factors into tumor-suppressing or onco-metabolites.",{"name":70,"@type":61,"acceptedAnswer":71},"What benefits and limitations of postbiotics are highlighted?",{"text":72,"@type":64},"Postbiotics may induce apoptosis in CRC, inhibit proliferation, affect invasion and migration, modulate immunity, suppress carcinogenic signaling, and support intestinal epithelial integrity, including synergy with chemotherapy. At the same time, some postbiotics can be ineffective and may carry safety risks in certain patients.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},339445,1790640503,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Current Nutrition Reports (2024) 13:126–151  \n[https://doi.org/10.1007/s13668-024-00525-z](https://doi.org/10.1007/s13668-024-00525-z)  \nThe Crucial Roles of Diet, Microbiota, and Postbiotics in Colorectal Cancer  \nRüya Kuru‑Yaşar1 · Özlem Üstün‑Aytekin1  \nAccepted: 25 February 2024 / Published online: 14 March 2024 © The Author(s) 2024  \nAbstract  \nPurpose of Review Colorectal cancer is the second deadliest cancer in the world, and its prevalence has been increasing alarmingly in recent years. After researchers discovered the existence of dysbiosis in colorectal cancer, they considered the use of probiotics in the treatment of colorectal cancer. However, for various reasons, including the low safety profile of probiotics in susceptible and immunocompromised patient5s, and the risk of developing antibiotic resistance, researchers have shifted their focus to non-living cells, their components, and metabolites. This review aims to comprehensively evaluate the literature on the effects of diet, microbiota, and postbiotics on colorectal cancer and the future of postbiotics.  \nRecent Findings The link between diet, gut microbiota, and colorectal cancer has been established primarily as a relationship rather than a cause-effect relationship. The gut microbiota can convert gastrointestinal tract and dietary factors into either onco-metabolites or tumor suppressor metabolites. There is serious dysbiosis in the microbiota in colorectal cancer. Postbiotics appear to be promising agents in the prevention and treatment of colorectal cancer.  \nSummary It has been shown that various postbiotics can selectively induce apoptosis in CRC, inhibit cell proliferation, growth, invasion, and migration, modulate the immune system, suppress carcinogenic signaling pathways, maintain intestinal epithelial integrity, and have a synergistic effect with chemotherapy drugs. However, it is also reported that some postbiotics are ineffective and may be risky in terms of safety profile in some patients. Many issues need to be researched about postbiotics. Large-scale, randomized, double-blind clinical studies are needed.  \nKeywords Diet · Microbiota · Dysbiosis · Postbiotics · Colorectal cancer  \nAbbreviations  \n5-FU 5-Fluorouracil  \nAKT A serine/threonine protein kinase AOM Azoxymethane  \nAPC Adenomatous polyposis coli  \nBAD BCL2-associated agonist of cell death BAK Bcl-2 homologous antagonist/killer BAX Bcl-2-associated X protein  \nBcl-xl B-cell lymphoma-extra-large  \nBcl-2 B-cell lymphoma 2  \nCFS Cell-free supernatant  \nCIMP CpG island methylator phenotype CIN Chromosomal instability  \nCRC Colorectal cancer  \n* Özlem Üstün-Aytekin [ozlem.aytekin@sbu.edu.tr](ozlem.aytekin@sbu.edu.tr)  \n1 Department of Nutrition and Dietetics, Hamidiye Faculty of Health Sciences, University of Health Sciences,  \n34668 Istanbul, Türkiye  \nDCC  \nDSS  \nEPS  \nGLUT-1  \nHDAC  \nIL  \nMSI  \nISAPP  \nSMAD2 K-ras MAPKMyD88  \nNADPH  \nNF-κB  \nNLRP3  \nOTUs  \nPARP  \nDeleted in colorectal cancer Dextran sodium sulfate Exopolysaccharides Glucose transporter-1  \nHistone deacetylase Interleukin Microsatellite instability  \nInternational Scientific Association for Probiotics and Prebiotics  \nMothers Against Decapentaplegic homolog 2 Kirsten rat sarcoma virus  \nMitogen-activated protein kinase  \nMyeloid differentiation primary response protein 88  \nNicotinamide adenine dinucleotide phosphate Nuclear factor kappa B  \nNucleotide-binding-domain-and leucine-rich repeat-containing family, pyrin-domaincontaining 3  \nOperational taxonomic units Poly ADP ribose polymerase  \nPI3K Phosphatidylinositol 3-kinase  \nRAS Rat sarcoma virus  \nROS Reactive oxygen species SCFAs Short-chain fatty acids S-layers Surface layers  \nSMO Smoothened  \nTMAO Trimethylamine-N-oxide TLR-4 Toll-like receptor-4  \nTNF-α Tumor necrosis factor alpha Wnt Wingless-related integration site  \nIntroduction  \nColorectal cancer (CRC), which includes cancers that occur in the colon and rectum, is the third most common type of cancer in onc","cbCaikHIpyp8uqeC","https://ap.wps.com/l/cbCaikHIpyp8uqeC","pdf",2653837,26,"English","# Introduction\n## Epidemiology and burden of colorectal cancer\n## Genetic and epigenetic pathways\n# Dysbiosis and dietary modulation\n# Postbiotics in prevention and treatment\n# Mechanistic effects and clinical evidence\n## Cellular effects (apoptosis, proliferation, invasion)\n## Immune modulation and pathway suppression\n## Safety concerns and research gaps\n# Future directions","[{\"question\":\"Why has research moved from probiotics to postbiotics for colorectal cancer?\",\"answer\":\"Probiotics raise safety concerns in susceptible and immunocompromised patients and may contribute to antibiotic resistance. The review discusses a shift toward non-living cells, their components, and metabolites, collectively captured by the postbiotic concept.\"},{\"question\":\"What does the review say about the relationship between diet, gut microbiota, and colorectal cancer?\",\"answer\":\"The link is established primarily as an association rather than a clear cause-effect relationship. Gut microbiota can transform gastrointestinal and dietary factors into tumor-suppressing or onco-metabolites.\"},{\"question\":\"What benefits and limitations of postbiotics are highlighted?\",\"answer\":\"Postbiotics may induce apoptosis in CRC, inhibit proliferation, affect invasion and migration, modulate immunity, suppress carcinogenic signaling, and support intestinal epithelial integrity, including synergy with chemotherapy. At the same time, some postbiotics can be ineffective and may carry safety risks in certain patients.\"}]","The Crucial Roles of Diet, Microbiota, and Postbiotics in Colorectal Cancer - Accepted and Published Online in 2024 | PDF",1790030333,66]